Signal peptide-CUB-EGF domain-containing protein 1 (SCUBE1) level in hemodialysis patients and parameters affecting that level
Signal peptide-CUB (complement C1r/C1s, Uegf, and Bmp1)-EGF (epidermal growth factor)-domain-containing protein 1 (SCUBE1) is a cell surface protein belonging to the SCUBE gene family. SCUBE1 has been shown to rise in parallel with platelet activation in acute ischemic events. However, there are no...
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| Veröffentlicht in: | Clinical biochemistry 2012-11, Vol.45 (16-17), p.1444-1449 |
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| creator | Ulusoy, Sukru Ozkan, Gulsum Menteşe, Ahmet Yavuz, Adnan Karahan, S. Caner Sümer, Ayşegül Uzun |
| description | Signal peptide-CUB (complement C1r/C1s, Uegf, and Bmp1)-EGF (epidermal growth factor)-domain-containing protein 1 (SCUBE1) is a cell surface protein belonging to the SCUBE gene family. SCUBE1 has been shown to rise in parallel with platelet activation in acute ischemic events. However, there are no studies showing levels in the hemodialysis patient group, in which there is known to be an increase in platelet function impairment and activation. The purpose of this study was to investigate SCUBE1 levels in a hemodialysis patient group and the factors affecting those levels.
One hundred three hemodialysis patients and 21 age-matched healthy controls were included. SCUBE1 and sCD40L levels were investigated from blood specimens collected on pre- and post-hemodialysis sessions. We investigated the correlation between SCUBE1 levels and sCD40L, patients' demographic data, parameters with hemodialysis treatment and routine biochemical tests.
SCUBE1 levels were significantly higher in the hemodialysis patient group compared with the controls (p=0.000). There was a significant rise in SCUBE1 levels in the post-hemodialysis session (p=0.000). We determined a positive correlation between SCUBE1 and sCD40L (p=0.016, r=0.215). Gender, blood pressure, BUN, creatinine, hematocrit and high-sensitivity C-reactive protein (hsCRP) levels, hemodialysis membrane surface area, amount of ultrafiltration, blood flow rate, dialysis flow rate and carnitine use significantly affected SCUBE1 levels.
We have shown, for the first time in the literature, that SCUBE1 level, a potential acute ischemia marker, is elevated in hemodialysis patients with no clinical ischemic event, and that various factors affect this elevation.
► SCUBE1 is a cell surface protein belonging to the SCUBE gene family. ► SCUBE1 an increase in acute ischemic events. ► There are no studies showing levels in the hemodialysis patient group. ► SCUBE1 level is elevated in hemodialysis patients without acute ischemic events. ► Various factors affect this elevation. |
| doi_str_mv | 10.1016/j.clinbiochem.2012.07.103 |
| format | Article |
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One hundred three hemodialysis patients and 21 age-matched healthy controls were included. SCUBE1 and sCD40L levels were investigated from blood specimens collected on pre- and post-hemodialysis sessions. We investigated the correlation between SCUBE1 levels and sCD40L, patients' demographic data, parameters with hemodialysis treatment and routine biochemical tests.
SCUBE1 levels were significantly higher in the hemodialysis patient group compared with the controls (p=0.000). There was a significant rise in SCUBE1 levels in the post-hemodialysis session (p=0.000). We determined a positive correlation between SCUBE1 and sCD40L (p=0.016, r=0.215). Gender, blood pressure, BUN, creatinine, hematocrit and high-sensitivity C-reactive protein (hsCRP) levels, hemodialysis membrane surface area, amount of ultrafiltration, blood flow rate, dialysis flow rate and carnitine use significantly affected SCUBE1 levels.
We have shown, for the first time in the literature, that SCUBE1 level, a potential acute ischemia marker, is elevated in hemodialysis patients with no clinical ischemic event, and that various factors affect this elevation.
► SCUBE1 is a cell surface protein belonging to the SCUBE gene family. ► SCUBE1 an increase in acute ischemic events. ► There are no studies showing levels in the hemodialysis patient group. ► SCUBE1 level is elevated in hemodialysis patients without acute ischemic events. ► Various factors affect this elevation.</description><identifier>ISSN: 0009-9120</identifier><identifier>EISSN: 1873-2933</identifier><identifier>DOI: 10.1016/j.clinbiochem.2012.07.103</identifier><identifier>PMID: 22874483</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Aged ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Carnitine - therapeutic use ; Case-Control Studies ; CD40 Ligand - blood ; Creatinine - blood ; Emergency and intensive care: renal failure. Dialysis management ; Erythropoietin - therapeutic use ; Female ; Hemodialysis ; Humans ; Intensive care medicine ; Investigative techniques, diagnostic techniques (general aspects) ; Kidney Failure, Chronic - blood ; Kidney Failure, Chronic - therapy ; Male ; Medical sciences ; Membrane Proteins - blood ; Middle Aged ; Renal Dialysis ; sCD40L ; SCUBE1 ; Signal peptide-CUB-EGF domain-containing protein 1 ; Vitamin B Complex - therapeutic use</subject><ispartof>Clinical biochemistry, 2012-11, Vol.45 (16-17), p.1444-1449</ispartof><rights>2012 The Canadian Society of Clinical Chemists</rights><rights>2014 INIST-CNRS</rights><rights>Copyright © 2012 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c407t-f477ef333561e3a9c3d6cb2b6fbcbe988088566796679c65b492dac76daf067a3</citedby><cites>FETCH-LOGICAL-c407t-f477ef333561e3a9c3d6cb2b6fbcbe988088566796679c65b492dac76daf067a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.clinbiochem.2012.07.103$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,45974</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26680139$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22874483$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ulusoy, Sukru</creatorcontrib><creatorcontrib>Ozkan, Gulsum</creatorcontrib><creatorcontrib>Menteşe, Ahmet</creatorcontrib><creatorcontrib>Yavuz, Adnan</creatorcontrib><creatorcontrib>Karahan, S. Caner</creatorcontrib><creatorcontrib>Sümer, Ayşegül Uzun</creatorcontrib><title>Signal peptide-CUB-EGF domain-containing protein 1 (SCUBE1) level in hemodialysis patients and parameters affecting that level</title><title>Clinical biochemistry</title><addtitle>Clin Biochem</addtitle><description>Signal peptide-CUB (complement C1r/C1s, Uegf, and Bmp1)-EGF (epidermal growth factor)-domain-containing protein 1 (SCUBE1) is a cell surface protein belonging to the SCUBE gene family. SCUBE1 has been shown to rise in parallel with platelet activation in acute ischemic events. However, there are no studies showing levels in the hemodialysis patient group, in which there is known to be an increase in platelet function impairment and activation. The purpose of this study was to investigate SCUBE1 levels in a hemodialysis patient group and the factors affecting those levels.
One hundred three hemodialysis patients and 21 age-matched healthy controls were included. SCUBE1 and sCD40L levels were investigated from blood specimens collected on pre- and post-hemodialysis sessions. We investigated the correlation between SCUBE1 levels and sCD40L, patients' demographic data, parameters with hemodialysis treatment and routine biochemical tests.
SCUBE1 levels were significantly higher in the hemodialysis patient group compared with the controls (p=0.000). There was a significant rise in SCUBE1 levels in the post-hemodialysis session (p=0.000). We determined a positive correlation between SCUBE1 and sCD40L (p=0.016, r=0.215). Gender, blood pressure, BUN, creatinine, hematocrit and high-sensitivity C-reactive protein (hsCRP) levels, hemodialysis membrane surface area, amount of ultrafiltration, blood flow rate, dialysis flow rate and carnitine use significantly affected SCUBE1 levels.
We have shown, for the first time in the literature, that SCUBE1 level, a potential acute ischemia marker, is elevated in hemodialysis patients with no clinical ischemic event, and that various factors affect this elevation.
► SCUBE1 is a cell surface protein belonging to the SCUBE gene family. ► SCUBE1 an increase in acute ischemic events. ► There are no studies showing levels in the hemodialysis patient group. ► SCUBE1 level is elevated in hemodialysis patients without acute ischemic events. ► Various factors affect this elevation.</description><subject>Aged</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Carnitine - therapeutic use</subject><subject>Case-Control Studies</subject><subject>CD40 Ligand - blood</subject><subject>Creatinine - blood</subject><subject>Emergency and intensive care: renal failure. Dialysis management</subject><subject>Erythropoietin - therapeutic use</subject><subject>Female</subject><subject>Hemodialysis</subject><subject>Humans</subject><subject>Intensive care medicine</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Kidney Failure, Chronic - blood</subject><subject>Kidney Failure, Chronic - therapy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Membrane Proteins - blood</subject><subject>Middle Aged</subject><subject>Renal Dialysis</subject><subject>sCD40L</subject><subject>SCUBE1</subject><subject>Signal peptide-CUB-EGF domain-containing protein 1</subject><subject>Vitamin B Complex - therapeutic use</subject><issn>0009-9120</issn><issn>1873-2933</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkEtvEzEQgC0EoqHwF9ByQCqHTf3Y-HGEKG2RKvVQera89rh1tOtdbKdSL_x2HCXQHnuwRuP5Zjz-EPpC8JJgws-3SzuE2IfJPsC4pJjQJRa1xN6gBZGCtVQx9hYtMMaqVYTiE_Qh521NaSf5e3RCqRRdJ9kC_bkN99EMzQxzCQ7a9d2PdnN50bhpNCG2doqlxhDvmzlNBUJsSHN2W6kN-dYM8AhDU-_qGpMLZnjKITezKQFiyY2JribJjFAg1dR7sGU_qjyYcmj-iN55M2T4dIyn6O5i82t91V7fXP5cf79ubYdFaX0nBHjG2IoTYEZZ5rjtac99b3tQUmIpV5wLtT-Wr_pOUWes4M54zIVhp-jsMLf-4vcOctFjyBaGwUSYdlkTwhQnnClVUXVAbZpyTuD1nMJo0pMmWO_1661-oV_v9WssaonV3s_HZ3b9CO5_5z_fFfh6BEy2ZvDJRBvyM8e5xHWVyq0PHFQpjwGSzrZKteBCqhK1m8Ir1vkLNAKpjA</recordid><startdate>20121101</startdate><enddate>20121101</enddate><creator>Ulusoy, Sukru</creator><creator>Ozkan, Gulsum</creator><creator>Menteşe, Ahmet</creator><creator>Yavuz, Adnan</creator><creator>Karahan, S. Caner</creator><creator>Sümer, Ayşegül Uzun</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20121101</creationdate><title>Signal peptide-CUB-EGF domain-containing protein 1 (SCUBE1) level in hemodialysis patients and parameters affecting that level</title><author>Ulusoy, Sukru ; Ozkan, Gulsum ; Menteşe, Ahmet ; Yavuz, Adnan ; Karahan, S. Caner ; Sümer, Ayşegül Uzun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c407t-f477ef333561e3a9c3d6cb2b6fbcbe988088566796679c65b492dac76daf067a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Aged</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Carnitine - therapeutic use</topic><topic>Case-Control Studies</topic><topic>CD40 Ligand - blood</topic><topic>Creatinine - blood</topic><topic>Emergency and intensive care: renal failure. Dialysis management</topic><topic>Erythropoietin - therapeutic use</topic><topic>Female</topic><topic>Hemodialysis</topic><topic>Humans</topic><topic>Intensive care medicine</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Kidney Failure, Chronic - blood</topic><topic>Kidney Failure, Chronic - therapy</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Membrane Proteins - blood</topic><topic>Middle Aged</topic><topic>Renal Dialysis</topic><topic>sCD40L</topic><topic>SCUBE1</topic><topic>Signal peptide-CUB-EGF domain-containing protein 1</topic><topic>Vitamin B Complex - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ulusoy, Sukru</creatorcontrib><creatorcontrib>Ozkan, Gulsum</creatorcontrib><creatorcontrib>Menteşe, Ahmet</creatorcontrib><creatorcontrib>Yavuz, Adnan</creatorcontrib><creatorcontrib>Karahan, S. Caner</creatorcontrib><creatorcontrib>Sümer, Ayşegül Uzun</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ulusoy, Sukru</au><au>Ozkan, Gulsum</au><au>Menteşe, Ahmet</au><au>Yavuz, Adnan</au><au>Karahan, S. Caner</au><au>Sümer, Ayşegül Uzun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Signal peptide-CUB-EGF domain-containing protein 1 (SCUBE1) level in hemodialysis patients and parameters affecting that level</atitle><jtitle>Clinical biochemistry</jtitle><addtitle>Clin Biochem</addtitle><date>2012-11-01</date><risdate>2012</risdate><volume>45</volume><issue>16-17</issue><spage>1444</spage><epage>1449</epage><pages>1444-1449</pages><issn>0009-9120</issn><eissn>1873-2933</eissn><abstract>Signal peptide-CUB (complement C1r/C1s, Uegf, and Bmp1)-EGF (epidermal growth factor)-domain-containing protein 1 (SCUBE1) is a cell surface protein belonging to the SCUBE gene family. SCUBE1 has been shown to rise in parallel with platelet activation in acute ischemic events. However, there are no studies showing levels in the hemodialysis patient group, in which there is known to be an increase in platelet function impairment and activation. The purpose of this study was to investigate SCUBE1 levels in a hemodialysis patient group and the factors affecting those levels.
One hundred three hemodialysis patients and 21 age-matched healthy controls were included. SCUBE1 and sCD40L levels were investigated from blood specimens collected on pre- and post-hemodialysis sessions. We investigated the correlation between SCUBE1 levels and sCD40L, patients' demographic data, parameters with hemodialysis treatment and routine biochemical tests.
SCUBE1 levels were significantly higher in the hemodialysis patient group compared with the controls (p=0.000). There was a significant rise in SCUBE1 levels in the post-hemodialysis session (p=0.000). We determined a positive correlation between SCUBE1 and sCD40L (p=0.016, r=0.215). Gender, blood pressure, BUN, creatinine, hematocrit and high-sensitivity C-reactive protein (hsCRP) levels, hemodialysis membrane surface area, amount of ultrafiltration, blood flow rate, dialysis flow rate and carnitine use significantly affected SCUBE1 levels.
We have shown, for the first time in the literature, that SCUBE1 level, a potential acute ischemia marker, is elevated in hemodialysis patients with no clinical ischemic event, and that various factors affect this elevation.
► SCUBE1 is a cell surface protein belonging to the SCUBE gene family. ► SCUBE1 an increase in acute ischemic events. ► There are no studies showing levels in the hemodialysis patient group. ► SCUBE1 level is elevated in hemodialysis patients without acute ischemic events. ► Various factors affect this elevation.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>22874483</pmid><doi>10.1016/j.clinbiochem.2012.07.103</doi><tpages>6</tpages></addata></record> |
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| subjects | Aged Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Carnitine - therapeutic use Case-Control Studies CD40 Ligand - blood Creatinine - blood Emergency and intensive care: renal failure. Dialysis management Erythropoietin - therapeutic use Female Hemodialysis Humans Intensive care medicine Investigative techniques, diagnostic techniques (general aspects) Kidney Failure, Chronic - blood Kidney Failure, Chronic - therapy Male Medical sciences Membrane Proteins - blood Middle Aged Renal Dialysis sCD40L SCUBE1 Signal peptide-CUB-EGF domain-containing protein 1 Vitamin B Complex - therapeutic use |
| title | Signal peptide-CUB-EGF domain-containing protein 1 (SCUBE1) level in hemodialysis patients and parameters affecting that level |
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