Direct β‑Acyloxylation of Enamines via PhIO-Mediated Intermolecular Oxidative C–O Bond Formation and Its Application to the Synthesis of Oxazoles

A direct β-acyloxylation of enamine compounds has been achieved by using iodosobenzene (PhIO) as an oxidant to realize the intermolecular oxidative C(sp 2)-O bond formation between enamines and various carboxylic acids, including N-protected amino acids. The transformation tolerates a wide range of...

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Veröffentlicht in:	Organic letters 2012-11, Vol.14 (21), p.5480-5483
Hauptverfasser:	Liu, Xin, Cheng, Ran, Zhao, Feifei, Zhang-Negrerie, Daisy, Du, Yunfei, Zhao, Kang
Format:	Artikel
Sprache:	eng
Schlagworte:	Amines - chemistry Carboxylic Acids - chemistry Catalysis Cyclization Molecular Structure Oxazoles - chemical synthesis Oxazoles - chemistry Oxidation-Reduction Stereoisomerism
Online-Zugang:	Volltext
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