Effects of unconjugated bilirubin on chromosomal damage in individuals with Gilbert's syndrome measured with the micronucleus cytome assay

Circulating unconjugated bilirubin (UCB) has been reported to protect against lung and colorectal cancer. The present study aimed to explore, for the first time, whether mildly elevated circulating UCB, as found in Gilbert`s syndrome (GS), is associated with changes of DNA damage. A random 76 indivi...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Mutagenesis 2012-11, Vol.27 (6), p.731-735
Hauptverfasser:	WALLNER, M, BLASSNIGG, S. M, BULMER, A. C, WAGNER, K. H, MARISCH, K, PAPPENHEIM, M. T, MÜLLNER, E, MÖLZER, C, NERSESYAN, A, MARCULESCU, R, DOBERER, D, KNASMÜLLER, S
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Bilirubin - adverse effects Bilirubin - blood Biological and medical sciences Chromosome Aberrations Colorectal Neoplasms - pathology Comet Assay - methods Cytokinesis DNA Damage Endpoint Determination Female Folic Acid - blood Fundamental and applied biological sciences. Psychology Gilbert Disease - blood Gilbert Disease - genetics Homocysteine - blood Humans Lung Neoplasms - pathology Lymphocytes - pathology Male Micronucleus Tests - methods Middle Aged Molecular and cellular biology Molecular genetics Mutagenesis. Repair Vitamin B 12 - blood Young Adult
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Circulating unconjugated bilirubin (UCB) has been reported to protect against lung and colorectal cancer. The present study aimed to explore, for the first time, whether mildly elevated circulating UCB, as found in Gilbert`s syndrome (GS), is associated with changes of DNA damage. A random 76 individuals, matched for age and gender, were recruited from the general population and allocated into the GS group (UCB ≥ 17.1 µM; n = 38) or control group (UCB
ISSN:	0267-8357 1464-3804
DOI:	10.1093/mutage/ges039