Cancer syndromes and therapy by stop-codon readthrough

Several hereditary cancer syndromes are associated with nonsense mutations that create premature termination codons (PTC). Therapeutic strategies involving readthrough induction partially restore expression of proteins with normal function from nonsense-mutated genes, and small molecules such as ami...

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Veröffentlicht in:	Trends in molecular medicine 2012-11, Vol.18 (11), p.667-678
Hauptverfasser:	Bordeira-Carriço, Renata, Pêgo, Ana Paula, Santos, Manuel, Oliveira, Carla
Format:	Artikel
Sprache:	eng
Schlagworte:	aminoglycosides Aminoglycosides - pharmacology Aminoglycosides - therapeutic use Animals Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Clinical Trials as Topic Codon, Nonsense Codon, Terminator Gene Transfer Techniques Genetic Therapy hereditary cancer syndromes Humans Neoplastic Syndromes, Hereditary - genetics Neoplastic Syndromes, Hereditary - therapy Nonsense Mediated mRNA Decay nonsense-mediated decay (NMD) nonsense-suppression Pathology premature termination codon (PTC) Protein Biosynthesis - drug effects PTC124 readthrough suppressor-tRNA
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