Impact of menopausal status on background parenchymal enhancement and fibroglandular tissue on breast MRI
Objective To evaluate the effect of menopausal status on the background parenchymal enhancement (BPE) and amount of fibroglandular tissue (FGT) on breast MRI. Methods Retrospective review identified 1,130 women who underwent screening breast MRI between July and November 2010. In 28 of these women,...
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| Veröffentlicht in: | European radiology 2012-12, Vol.22 (12), p.2641-2647 |
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| creator | King, Valencia Gu, Yajia Kaplan, Jennifer B. Brooks, Jennifer D. Pike, Malcolm C. Morris, Elizabeth A |
| description | Objective
To evaluate the effect of menopausal status on the background parenchymal enhancement (BPE) and amount of fibroglandular tissue (FGT) on breast MRI.
Methods
Retrospective review identified 1,130 women who underwent screening breast MRI between July and November 2010. In 28 of these women, breast MRI was performed both at one time point while pre- and one time point while post-menopausal (median interval 49 months). Two independent readers blinded to menopausal status used categorical scales to rate BPE (minimal/mild/moderate/marked) and FGT (fatty/scattered/heterogeneously dense/dense). Consensus was reached when there was disagreement. The sign test was used to assess changes in rating categories, and the Spearman rank and Fisher’s exact tests were used to measure correlations and associations between variables.
Results
Significant proportions of women demonstrated decreases in BPE and FGT on post-menopausal breast MRI (
P
= 0.0001 and
P
= 0.0009). BPE category was unchanged in 39 % (11/28) and decreased in 61 % (17/28) of women. FGT category was unchanged in 61 % (17/28) and decreased in 39 % (11/28) of women. Age, reason for menopause, or interval between MRIs had no significant impact on changes in BPE and FGT.
Conclusion
On MRI, BPE, and FGT decrease after menopause in significant proportions of women; BPE decreases more than FGT.
Key Points
• On MRI, background parenchymal enhancement and fibroglandular tissue both decrease after menopause.
• The reduced postmenopausal enhancement is more marked in parenchyma than fibroglandular tissue.
• Background enhancement and fibroglandular tissue seen on MRI are under hormonal influence. |
| doi_str_mv | 10.1007/s00330-012-2553-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1126612625</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1126612625</sourcerecordid><originalsourceid>FETCH-LOGICAL-c438t-e933779a6cb26da7faaa58e61c45aad254fd01f8b3aa46ec84724c72babf586e3</originalsourceid><addsrcrecordid>eNp1kU9v1DAQxS0EotvCB-CCLHHhEvB_O0dUFVipCAnB2Zo4k21KEgc7PvTb4-2WCiFxsMbS_N6b0TxCXnH2jjNm32fGpGQN46IRWsvGPSE7rqRoOHPqKdmxVrrGtq06I-c53zLGWq7sc3ImhNVCGbkj435eIWw0DnTGJa5QMkw0b7CVTONCOwg_DymWpacrJFzCzd1cAVxuYAlYJRuF2hvGLsXDVL9lgkS3MeeC9_qEkDf65dv-BXk2wJTx5UO9ID8-Xn2__Nxcf_20v_xw3QQl3dZgK6W1LZjQCdODHQBAOzQ8KA3QC62GnvHBdRJAGQxOWaGCFR10g3YG5QV5e_JdU_xVMG9-HnPAqS6HsWTPuTCmPqEr-uYf9DaWtNTtjpQWxrF7ip-okGLOCQe_pnGGdOc588cc_CkHX3Pwxxy8q5rXD86lm7F_VPw5fAXECci1tRww_TX6v66_AaODlBY</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1125268025</pqid></control><display><type>article</type><title>Impact of menopausal status on background parenchymal enhancement and fibroglandular tissue on breast MRI</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>King, Valencia ; Gu, Yajia ; Kaplan, Jennifer B. ; Brooks, Jennifer D. ; Pike, Malcolm C. ; Morris, Elizabeth A</creator><creatorcontrib>King, Valencia ; Gu, Yajia ; Kaplan, Jennifer B. ; Brooks, Jennifer D. ; Pike, Malcolm C. ; Morris, Elizabeth A</creatorcontrib><description>Objective
To evaluate the effect of menopausal status on the background parenchymal enhancement (BPE) and amount of fibroglandular tissue (FGT) on breast MRI.
Methods
Retrospective review identified 1,130 women who underwent screening breast MRI between July and November 2010. In 28 of these women, breast MRI was performed both at one time point while pre- and one time point while post-menopausal (median interval 49 months). Two independent readers blinded to menopausal status used categorical scales to rate BPE (minimal/mild/moderate/marked) and FGT (fatty/scattered/heterogeneously dense/dense). Consensus was reached when there was disagreement. The sign test was used to assess changes in rating categories, and the Spearman rank and Fisher’s exact tests were used to measure correlations and associations between variables.
Results
Significant proportions of women demonstrated decreases in BPE and FGT on post-menopausal breast MRI (
P
= 0.0001 and
P
= 0.0009). BPE category was unchanged in 39 % (11/28) and decreased in 61 % (17/28) of women. FGT category was unchanged in 61 % (17/28) and decreased in 39 % (11/28) of women. Age, reason for menopause, or interval between MRIs had no significant impact on changes in BPE and FGT.
Conclusion
On MRI, BPE, and FGT decrease after menopause in significant proportions of women; BPE decreases more than FGT.
Key Points
• On MRI, background parenchymal enhancement and fibroglandular tissue both decrease after menopause.
• The reduced postmenopausal enhancement is more marked in parenchyma than fibroglandular tissue.
• Background enhancement and fibroglandular tissue seen on MRI are under hormonal influence.</description><identifier>ISSN: 0938-7994</identifier><identifier>EISSN: 1432-1084</identifier><identifier>DOI: 10.1007/s00330-012-2553-8</identifier><identifier>PMID: 22752463</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Adult ; Biopsy ; Breast ; Breast cancer ; Breast Neoplasms - diagnosis ; Breast Neoplasms - pathology ; Cancer therapies ; Chemotherapy ; Contrast Media ; Diagnostic Radiology ; Family medical history ; Female ; Gadolinium DTPA ; Humans ; Image Enhancement - methods ; Imaging ; Internal Medicine ; Interventional Radiology ; Magnetic Resonance Imaging - methods ; Medicine ; Medicine & Public Health ; Menopause ; Menstruation ; Middle Aged ; Neuroradiology ; Patients ; Postmenopause ; Premenopause ; Radiation ; Radiology ; Retrospective Studies ; Risk Factors ; Subtraction Technique ; Ultrasound ; Womens health</subject><ispartof>European radiology, 2012-12, Vol.22 (12), p.2641-2647</ispartof><rights>European Society of Radiology 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-e933779a6cb26da7faaa58e61c45aad254fd01f8b3aa46ec84724c72babf586e3</citedby><cites>FETCH-LOGICAL-c438t-e933779a6cb26da7faaa58e61c45aad254fd01f8b3aa46ec84724c72babf586e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00330-012-2553-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00330-012-2553-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22752463$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>King, Valencia</creatorcontrib><creatorcontrib>Gu, Yajia</creatorcontrib><creatorcontrib>Kaplan, Jennifer B.</creatorcontrib><creatorcontrib>Brooks, Jennifer D.</creatorcontrib><creatorcontrib>Pike, Malcolm C.</creatorcontrib><creatorcontrib>Morris, Elizabeth A</creatorcontrib><title>Impact of menopausal status on background parenchymal enhancement and fibroglandular tissue on breast MRI</title><title>European radiology</title><addtitle>Eur Radiol</addtitle><addtitle>Eur Radiol</addtitle><description>Objective
To evaluate the effect of menopausal status on the background parenchymal enhancement (BPE) and amount of fibroglandular tissue (FGT) on breast MRI.
Methods
Retrospective review identified 1,130 women who underwent screening breast MRI between July and November 2010. In 28 of these women, breast MRI was performed both at one time point while pre- and one time point while post-menopausal (median interval 49 months). Two independent readers blinded to menopausal status used categorical scales to rate BPE (minimal/mild/moderate/marked) and FGT (fatty/scattered/heterogeneously dense/dense). Consensus was reached when there was disagreement. The sign test was used to assess changes in rating categories, and the Spearman rank and Fisher’s exact tests were used to measure correlations and associations between variables.
Results
Significant proportions of women demonstrated decreases in BPE and FGT on post-menopausal breast MRI (
P
= 0.0001 and
P
= 0.0009). BPE category was unchanged in 39 % (11/28) and decreased in 61 % (17/28) of women. FGT category was unchanged in 61 % (17/28) and decreased in 39 % (11/28) of women. Age, reason for menopause, or interval between MRIs had no significant impact on changes in BPE and FGT.
Conclusion
On MRI, BPE, and FGT decrease after menopause in significant proportions of women; BPE decreases more than FGT.
Key Points
• On MRI, background parenchymal enhancement and fibroglandular tissue both decrease after menopause.
• The reduced postmenopausal enhancement is more marked in parenchyma than fibroglandular tissue.
• Background enhancement and fibroglandular tissue seen on MRI are under hormonal influence.</description><subject>Adult</subject><subject>Biopsy</subject><subject>Breast</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - diagnosis</subject><subject>Breast Neoplasms - pathology</subject><subject>Cancer therapies</subject><subject>Chemotherapy</subject><subject>Contrast Media</subject><subject>Diagnostic Radiology</subject><subject>Family medical history</subject><subject>Female</subject><subject>Gadolinium DTPA</subject><subject>Humans</subject><subject>Image Enhancement - methods</subject><subject>Imaging</subject><subject>Internal Medicine</subject><subject>Interventional Radiology</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Menopause</subject><subject>Menstruation</subject><subject>Middle Aged</subject><subject>Neuroradiology</subject><subject>Patients</subject><subject>Postmenopause</subject><subject>Premenopause</subject><subject>Radiation</subject><subject>Radiology</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Subtraction Technique</subject><subject>Ultrasound</subject><subject>Womens health</subject><issn>0938-7994</issn><issn>1432-1084</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kU9v1DAQxS0EotvCB-CCLHHhEvB_O0dUFVipCAnB2Zo4k21KEgc7PvTb4-2WCiFxsMbS_N6b0TxCXnH2jjNm32fGpGQN46IRWsvGPSE7rqRoOHPqKdmxVrrGtq06I-c53zLGWq7sc3ImhNVCGbkj435eIWw0DnTGJa5QMkw0b7CVTONCOwg_DymWpacrJFzCzd1cAVxuYAlYJRuF2hvGLsXDVL9lgkS3MeeC9_qEkDf65dv-BXk2wJTx5UO9ID8-Xn2__Nxcf_20v_xw3QQl3dZgK6W1LZjQCdODHQBAOzQ8KA3QC62GnvHBdRJAGQxOWaGCFR10g3YG5QV5e_JdU_xVMG9-HnPAqS6HsWTPuTCmPqEr-uYf9DaWtNTtjpQWxrF7ip-okGLOCQe_pnGGdOc588cc_CkHX3Pwxxy8q5rXD86lm7F_VPw5fAXECci1tRww_TX6v66_AaODlBY</recordid><startdate>20121201</startdate><enddate>20121201</enddate><creator>King, Valencia</creator><creator>Gu, Yajia</creator><creator>Kaplan, Jennifer B.</creator><creator>Brooks, Jennifer D.</creator><creator>Pike, Malcolm C.</creator><creator>Morris, Elizabeth A</creator><general>Springer-Verlag</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20121201</creationdate><title>Impact of menopausal status on background parenchymal enhancement and fibroglandular tissue on breast MRI</title><author>King, Valencia ; Gu, Yajia ; Kaplan, Jennifer B. ; Brooks, Jennifer D. ; Pike, Malcolm C. ; Morris, Elizabeth A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-e933779a6cb26da7faaa58e61c45aad254fd01f8b3aa46ec84724c72babf586e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Biopsy</topic><topic>Breast</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - diagnosis</topic><topic>Breast Neoplasms - pathology</topic><topic>Cancer therapies</topic><topic>Chemotherapy</topic><topic>Contrast Media</topic><topic>Diagnostic Radiology</topic><topic>Family medical history</topic><topic>Female</topic><topic>Gadolinium DTPA</topic><topic>Humans</topic><topic>Image Enhancement - methods</topic><topic>Imaging</topic><topic>Internal Medicine</topic><topic>Interventional Radiology</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Menopause</topic><topic>Menstruation</topic><topic>Middle Aged</topic><topic>Neuroradiology</topic><topic>Patients</topic><topic>Postmenopause</topic><topic>Premenopause</topic><topic>Radiation</topic><topic>Radiology</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Subtraction Technique</topic><topic>Ultrasound</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>King, Valencia</creatorcontrib><creatorcontrib>Gu, Yajia</creatorcontrib><creatorcontrib>Kaplan, Jennifer B.</creatorcontrib><creatorcontrib>Brooks, Jennifer D.</creatorcontrib><creatorcontrib>Pike, Malcolm C.</creatorcontrib><creatorcontrib>Morris, Elizabeth A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Applied & Life Sciences</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>European radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>King, Valencia</au><au>Gu, Yajia</au><au>Kaplan, Jennifer B.</au><au>Brooks, Jennifer D.</au><au>Pike, Malcolm C.</au><au>Morris, Elizabeth A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of menopausal status on background parenchymal enhancement and fibroglandular tissue on breast MRI</atitle><jtitle>European radiology</jtitle><stitle>Eur Radiol</stitle><addtitle>Eur Radiol</addtitle><date>2012-12-01</date><risdate>2012</risdate><volume>22</volume><issue>12</issue><spage>2641</spage><epage>2647</epage><pages>2641-2647</pages><issn>0938-7994</issn><eissn>1432-1084</eissn><abstract>Objective
To evaluate the effect of menopausal status on the background parenchymal enhancement (BPE) and amount of fibroglandular tissue (FGT) on breast MRI.
Methods
Retrospective review identified 1,130 women who underwent screening breast MRI between July and November 2010. In 28 of these women, breast MRI was performed both at one time point while pre- and one time point while post-menopausal (median interval 49 months). Two independent readers blinded to menopausal status used categorical scales to rate BPE (minimal/mild/moderate/marked) and FGT (fatty/scattered/heterogeneously dense/dense). Consensus was reached when there was disagreement. The sign test was used to assess changes in rating categories, and the Spearman rank and Fisher’s exact tests were used to measure correlations and associations between variables.
Results
Significant proportions of women demonstrated decreases in BPE and FGT on post-menopausal breast MRI (
P
= 0.0001 and
P
= 0.0009). BPE category was unchanged in 39 % (11/28) and decreased in 61 % (17/28) of women. FGT category was unchanged in 61 % (17/28) and decreased in 39 % (11/28) of women. Age, reason for menopause, or interval between MRIs had no significant impact on changes in BPE and FGT.
Conclusion
On MRI, BPE, and FGT decrease after menopause in significant proportions of women; BPE decreases more than FGT.
Key Points
• On MRI, background parenchymal enhancement and fibroglandular tissue both decrease after menopause.
• The reduced postmenopausal enhancement is more marked in parenchyma than fibroglandular tissue.
• Background enhancement and fibroglandular tissue seen on MRI are under hormonal influence.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>22752463</pmid><doi>10.1007/s00330-012-2553-8</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0938-7994 |
| ispartof | European radiology, 2012-12, Vol.22 (12), p.2641-2647 |
| issn | 0938-7994 1432-1084 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1126612625 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Adult Biopsy Breast Breast cancer Breast Neoplasms - diagnosis Breast Neoplasms - pathology Cancer therapies Chemotherapy Contrast Media Diagnostic Radiology Family medical history Female Gadolinium DTPA Humans Image Enhancement - methods Imaging Internal Medicine Interventional Radiology Magnetic Resonance Imaging - methods Medicine Medicine & Public Health Menopause Menstruation Middle Aged Neuroradiology Patients Postmenopause Premenopause Radiation Radiology Retrospective Studies Risk Factors Subtraction Technique Ultrasound Womens health |
| title | Impact of menopausal status on background parenchymal enhancement and fibroglandular tissue on breast MRI |
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