Early detection of non-ST-elevation myocardial infarction in geriatric patients by a new high-sensitive cardiac troponin T assay
Background and aims : The new high sensitivity cardiac Troponin T (cTnThs) assay has recently been introduced in our clinic and ensures higher sensitivity than the fourth-generation cardiac troponin T (cTnT) assay from the same manufacturer (Roche Diagnostics). We determined the diagnostic performan...
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| Veröffentlicht in: | Aging clinical and experimental research 2012-06, Vol.24 (3), p.290-294 |
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| creator | Bahrmann, Philipp Heppner, Hans-Juergen Christ, Michael Bertsch, Thomas Sieber, Cornel |
| description | Background and aims
: The new high sensitivity cardiac Troponin T (cTnThs) assay has recently been introduced in our clinic and ensures higher sensitivity than the fourth-generation cardiac troponin T (cTnT) assay from the same manufacturer (Roche Diagnostics). We determined the diagnostic performance of the cTnThs compared with the cTnT assay in geriatric patients, especially those with non-ST elevation myocardial infarction (NSTEMI).
Methods
: We retrospectively analysed 253 patients (age 82±8 years; 82 men, 172 women) with diagnoses of suspected NSTEMI admitted to our Department of Geriatric Medicine. Patients were divided into one group of 113 patients using cTnThs, and another of 140 patients using cTnT for diagnosis. Each group included patients at the same months but different years, in either cTnThs or cTnT assays. NSTEMI was diagnosed according to current guidelines.
Results
: Baseline characteristics were similar in both groups. The proportions of patients with elevated cardiac troponin (cTn) levels significantly increased from 35% in the cTnT group to 76% in the cTnThs group (p |
| doi_str_mv | 10.3275/7927 |
| format | Article |
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: The new high sensitivity cardiac Troponin T (cTnThs) assay has recently been introduced in our clinic and ensures higher sensitivity than the fourth-generation cardiac troponin T (cTnT) assay from the same manufacturer (Roche Diagnostics). We determined the diagnostic performance of the cTnThs compared with the cTnT assay in geriatric patients, especially those with non-ST elevation myocardial infarction (NSTEMI).
Methods
: We retrospectively analysed 253 patients (age 82±8 years; 82 men, 172 women) with diagnoses of suspected NSTEMI admitted to our Department of Geriatric Medicine. Patients were divided into one group of 113 patients using cTnThs, and another of 140 patients using cTnT for diagnosis. Each group included patients at the same months but different years, in either cTnThs or cTnT assays. NSTEMI was diagnosed according to current guidelines.
Results
: Baseline characteristics were similar in both groups. The proportions of patients with elevated cardiac troponin (cTn) levels significantly increased from 35% in the cTnT group to 76% in the cTnThs group (p<0.001), although no coronary cause for the elevated cTn levels was shown in about two-thirds of these patients. In patients with NSTEMI, 58% in the cTnThs group vs 42% in the cTnT group were diagnosed within 4 hours of the onset of symptoms, whereas 42% in the cTnThs group vs 58% in the cTnT group were diagnosed more than 4 hours later (p=0.018).
Conclusions
: The prevalence of elevated cTn has more than doubled with the use of cTnThs. However, no coronary cause was found in two-thirds of our geriatric patients, although more NSTEMI patients were diagnosed earlier by cTnThs.</description><identifier>ISSN: 1594-0667</identifier><identifier>EISSN: 1720-8319</identifier><identifier>DOI: 10.3275/7927</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Geriatrics/Gerontology ; Medicine ; Medicine & Public Health ; Short Communication</subject><ispartof>Aging clinical and experimental research, 2012-06, Vol.24 (3), p.290-294</ispartof><rights>Springer Internal Publishing Switzerland 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c253t-6ca223b405b08fefa8fb7911cf9cb1a8854f54af80fcf2a8148089fc7ad9cf453</citedby><cites>FETCH-LOGICAL-c253t-6ca223b405b08fefa8fb7911cf9cb1a8854f54af80fcf2a8148089fc7ad9cf453</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.3275/7927$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.3275/7927$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids></links><search><creatorcontrib>Bahrmann, Philipp</creatorcontrib><creatorcontrib>Heppner, Hans-Juergen</creatorcontrib><creatorcontrib>Christ, Michael</creatorcontrib><creatorcontrib>Bertsch, Thomas</creatorcontrib><creatorcontrib>Sieber, Cornel</creatorcontrib><title>Early detection of non-ST-elevation myocardial infarction in geriatric patients by a new high-sensitive cardiac troponin T assay</title><title>Aging clinical and experimental research</title><addtitle>Aging Clin Exp Res</addtitle><description>Background and aims
: The new high sensitivity cardiac Troponin T (cTnThs) assay has recently been introduced in our clinic and ensures higher sensitivity than the fourth-generation cardiac troponin T (cTnT) assay from the same manufacturer (Roche Diagnostics). We determined the diagnostic performance of the cTnThs compared with the cTnT assay in geriatric patients, especially those with non-ST elevation myocardial infarction (NSTEMI).
Methods
: We retrospectively analysed 253 patients (age 82±8 years; 82 men, 172 women) with diagnoses of suspected NSTEMI admitted to our Department of Geriatric Medicine. Patients were divided into one group of 113 patients using cTnThs, and another of 140 patients using cTnT for diagnosis. Each group included patients at the same months but different years, in either cTnThs or cTnT assays. NSTEMI was diagnosed according to current guidelines.
Results
: Baseline characteristics were similar in both groups. The proportions of patients with elevated cardiac troponin (cTn) levels significantly increased from 35% in the cTnT group to 76% in the cTnThs group (p<0.001), although no coronary cause for the elevated cTn levels was shown in about two-thirds of these patients. In patients with NSTEMI, 58% in the cTnThs group vs 42% in the cTnT group were diagnosed within 4 hours of the onset of symptoms, whereas 42% in the cTnThs group vs 58% in the cTnT group were diagnosed more than 4 hours later (p=0.018).
Conclusions
: The prevalence of elevated cTn has more than doubled with the use of cTnThs. However, no coronary cause was found in two-thirds of our geriatric patients, although more NSTEMI patients were diagnosed earlier by cTnThs.</description><subject>Geriatrics/Gerontology</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Short Communication</subject><issn>1594-0667</issn><issn>1720-8319</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNotkE9PAyEQxYnRxNr6HbiYeEGBXXbhaJr6J2niwXrezFJoabZQgdbszY_u1vU0k5nfvLx5CM0YfSh4LR5rxesLNGE1p0QWTF0OvVAloVVVX6OblHaUlmxYTNDPAmLX47XJRmcXPA4W--DJx4qYzpzgb7bvg4a4dtBh5y3EkXQeb0x0kKPT-DCQxueE2x4D9uYbb91mS5LxyWV3MngU0DjHcAh-uF1hSAn6Gbqy0CVz-1-n6PN5sZq_kuX7y9v8aUk0F0UmlQbOi7akoqXSGgvStrViTFulWwZSitKKEqykVlsOkpWSSmV1DWulbSmKKbofdQ8xfB1Nys3eJW26DrwJx9QwxiuhJBVsQO9GNB2i88OPzS4cox_cNYw254Sbc8LFL9FGb9Y</recordid><startdate>20120601</startdate><enddate>20120601</enddate><creator>Bahrmann, Philipp</creator><creator>Heppner, Hans-Juergen</creator><creator>Christ, Michael</creator><creator>Bertsch, Thomas</creator><creator>Sieber, Cornel</creator><general>Springer International Publishing</general><scope>7X8</scope></search><sort><creationdate>20120601</creationdate><title>Early detection of non-ST-elevation myocardial infarction in geriatric patients by a new high-sensitive cardiac troponin T assay</title><author>Bahrmann, Philipp ; Heppner, Hans-Juergen ; Christ, Michael ; Bertsch, Thomas ; Sieber, Cornel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c253t-6ca223b405b08fefa8fb7911cf9cb1a8854f54af80fcf2a8148089fc7ad9cf453</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Geriatrics/Gerontology</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Short Communication</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bahrmann, Philipp</creatorcontrib><creatorcontrib>Heppner, Hans-Juergen</creatorcontrib><creatorcontrib>Christ, Michael</creatorcontrib><creatorcontrib>Bertsch, Thomas</creatorcontrib><creatorcontrib>Sieber, Cornel</creatorcontrib><collection>MEDLINE - Academic</collection><jtitle>Aging clinical and experimental research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bahrmann, Philipp</au><au>Heppner, Hans-Juergen</au><au>Christ, Michael</au><au>Bertsch, Thomas</au><au>Sieber, Cornel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Early detection of non-ST-elevation myocardial infarction in geriatric patients by a new high-sensitive cardiac troponin T assay</atitle><jtitle>Aging clinical and experimental research</jtitle><stitle>Aging Clin Exp Res</stitle><date>2012-06-01</date><risdate>2012</risdate><volume>24</volume><issue>3</issue><spage>290</spage><epage>294</epage><pages>290-294</pages><issn>1594-0667</issn><eissn>1720-8319</eissn><abstract>Background and aims
: The new high sensitivity cardiac Troponin T (cTnThs) assay has recently been introduced in our clinic and ensures higher sensitivity than the fourth-generation cardiac troponin T (cTnT) assay from the same manufacturer (Roche Diagnostics). We determined the diagnostic performance of the cTnThs compared with the cTnT assay in geriatric patients, especially those with non-ST elevation myocardial infarction (NSTEMI).
Methods
: We retrospectively analysed 253 patients (age 82±8 years; 82 men, 172 women) with diagnoses of suspected NSTEMI admitted to our Department of Geriatric Medicine. Patients were divided into one group of 113 patients using cTnThs, and another of 140 patients using cTnT for diagnosis. Each group included patients at the same months but different years, in either cTnThs or cTnT assays. NSTEMI was diagnosed according to current guidelines.
Results
: Baseline characteristics were similar in both groups. The proportions of patients with elevated cardiac troponin (cTn) levels significantly increased from 35% in the cTnT group to 76% in the cTnThs group (p<0.001), although no coronary cause for the elevated cTn levels was shown in about two-thirds of these patients. In patients with NSTEMI, 58% in the cTnThs group vs 42% in the cTnT group were diagnosed within 4 hours of the onset of symptoms, whereas 42% in the cTnThs group vs 58% in the cTnT group were diagnosed more than 4 hours later (p=0.018).
Conclusions
: The prevalence of elevated cTn has more than doubled with the use of cTnThs. However, no coronary cause was found in two-thirds of our geriatric patients, although more NSTEMI patients were diagnosed earlier by cTnThs.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><doi>10.3275/7927</doi><tpages>5</tpages></addata></record> |
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| subjects | Geriatrics/Gerontology Medicine Medicine & Public Health Short Communication |
| title | Early detection of non-ST-elevation myocardial infarction in geriatric patients by a new high-sensitive cardiac troponin T assay |
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