Plasmacytoid dendritic cells induce efficient stimulation of antiviral immunity in the context of chronic hepatitis B virus infection

The immune control of hepatitis B virus (HBV) infection is essential for viral clearance. Therefore, restoring functional anti–HBV immunity is a promising immunotherapeutic approach to treatment of chronic infection. Plasmacytoid dendritic cells (pDCs) play a crucial role in triggering antiviral imm...

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Veröffentlicht in:	Hepatology (Baltimore, Md.) Md.), 2012-11, Vol.56 (5), p.1706-1718
Hauptverfasser:	Martinet, Jeremie, Leroy, Vincent, Dufeu-Duchesne, Tania, Larrat, Sylvie, Richard, Marie-Jeanne, Zoulim, Fabien, Plumas, Joel, Aspord, Caroline
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive Immunity Adult Aged Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Biological and medical sciences CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism Dendritic Cells - immunology Dendritic Cells - metabolism Dendritic Cells - transplantation Disease Models, Animal Female Gastroenterology. Liver. Pancreas. Abdomen Hep G2 Cells Hepatitis Hepatitis B Hepatitis B - blood Hepatitis B - genetics Hepatitis B - immunology Hepatitis B Core Antigens - immunology Hepatitis B Core Antigens - metabolism Hepatitis B e Antigens - blood Hepatitis B e Antigens - immunology Hepatitis B Surface Antigens - immunology Hepatitis B Surface Antigens - metabolism Hepatitis B Vaccines - immunology Hepatitis B virus - genetics Hepatitis B virus - immunology Hepatocytes - immunology Hepatology HLA-A Antigens - genetics HLA-A Antigens - immunology HLA-A Antigens - metabolism Human viral diseases Humans Immunology Infectious diseases Interferon-gamma - metabolism Leukocytes, Mononuclear Liver. Biliary tract. Portal circulation. Exocrine pancreas Lymphocytes Lysosomal-Associated Membrane Protein 1 - metabolism Lysosomal-Associated Membrane Protein 2 - metabolism Male Medical sciences Mice Mice, Inbred NOD Mice, SCID Middle Aged Pharmacology. Drug treatments Transfection Viral diseases Viral hepatitis Viral Load Young Adult
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