Tracing hepatitis B virus to the 16th century in a Korean mummy
A rare find of a mummified child from the 16th century AD, in Korea, with relatively preserved organs, enabled a search for ancient hepatitis B virus (aHBV) DNA sequences from laparoscopic‐derived liver biopsies. Analysis of the complete aHBV genome (3,215 base pairs) revealed a unique HBV genotype...
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| Veröffentlicht in: | Hepatology (Baltimore, Md.) Md.), 2012-11, Vol.56 (5), p.1671-1680 |
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| creator | Kahila Bar-Gal, Gila Kim, Myeung Ju Klein, Athalia Shin, Dong Hoon Oh, Chang Seok Kim, Jong Wan Kim, Tae-Hyun Kim, Seok Bae Grant, Paul R. Pappo, Orit Spigelman, Mark Shouval, Daniel |
| description | A rare find of a mummified child from the 16th century AD, in Korea, with relatively preserved organs, enabled a search for ancient hepatitis B virus (aHBV) DNA sequences from laparoscopic‐derived liver biopsies. Analysis of the complete aHBV genome (3,215 base pairs) revealed a unique HBV genotype C2 (HBV/C2) sequence commonly spread in Southeast Asia, which probably represents an HBV that infected the Joseon Dynasty population in Korea. Comparison of the aHBV sequences with contemporary HBV/C2 DNA sequences revealed distinctive differences along four open reading frames. Genetic diversity between contemporary and recovered aHBV/C2 DNA may be the result of immunologic, environmental, and/or pharmacologic pressures. The calculated time of most recent common ancestor suggests that the Korean HBV sequence origin dates back at least 3,000 years and possibly as long as 100,000 years. This isolate most likely represents the earliest human HBV sequence that colonized Southeast Asia by human migration. Conclusion: This study describes the complete sequence of the oldest HBV isolate and the most ancient full viral genome known so far. (HEPATOLOGY 2012;56:1671–1680) |
| doi_str_mv | 10.1002/hep.25852 |
| format | Article |
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Analysis of the complete aHBV genome (3,215 base pairs) revealed a unique HBV genotype C2 (HBV/C2) sequence commonly spread in Southeast Asia, which probably represents an HBV that infected the Joseon Dynasty population in Korea. Comparison of the aHBV sequences with contemporary HBV/C2 DNA sequences revealed distinctive differences along four open reading frames. Genetic diversity between contemporary and recovered aHBV/C2 DNA may be the result of immunologic, environmental, and/or pharmacologic pressures. The calculated time of most recent common ancestor suggests that the Korean HBV sequence origin dates back at least 3,000 years and possibly as long as 100,000 years. This isolate most likely represents the earliest human HBV sequence that colonized Southeast Asia by human migration. Conclusion: This study describes the complete sequence of the oldest HBV isolate and the most ancient full viral genome known so far. (HEPATOLOGY 2012;56:1671–1680)</description><identifier>ISSN: 0270-9139</identifier><identifier>EISSN: 1527-3350</identifier><identifier>DOI: 10.1002/hep.25852</identifier><identifier>PMID: 22610996</identifier><identifier>CODEN: HPTLD9</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Asian Continental Ancestry Group - genetics ; Biological and medical sciences ; Child ; Deoxyribonucleic acid ; Disease transmission ; DNA ; DNA, Viral - genetics ; Gastroenterology. Liver. Pancreas. Abdomen ; Genetic Variation ; Genome, Viral ; Genomes ; Hepatitis ; Hepatitis B ; Hepatitis B virus - genetics ; Hepatitis B virus - isolation & purification ; Hepatitis B, Chronic - history ; Hepatitis B, Chronic - pathology ; Hepatitis B, Chronic - virology ; Hepatology ; History, 16th Century ; Humans ; Korea ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Medical sciences ; Mummies - virology ; Phylogeny ; Phylogeography ; Sequence Analysis, DNA</subject><ispartof>Hepatology (Baltimore, Md.), 2012-11, Vol.56 (5), p.1671-1680</ispartof><rights>Copyright © 2012 American Association for the Study of Liver Diseases</rights><rights>2014 INIST-CNRS</rights><rights>Copyright © 2012 American Association for the Study of Liver Diseases.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4872-efd7155ae24455dc27bb6b48c62715d82734fb789464ef07b80ddc827858df023</citedby><cites>FETCH-LOGICAL-c4872-efd7155ae24455dc27bb6b48c62715d82734fb789464ef07b80ddc827858df023</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fhep.25852$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fhep.25852$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26679274$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22610996$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kahila Bar-Gal, Gila</creatorcontrib><creatorcontrib>Kim, Myeung Ju</creatorcontrib><creatorcontrib>Klein, Athalia</creatorcontrib><creatorcontrib>Shin, Dong Hoon</creatorcontrib><creatorcontrib>Oh, Chang Seok</creatorcontrib><creatorcontrib>Kim, Jong Wan</creatorcontrib><creatorcontrib>Kim, Tae-Hyun</creatorcontrib><creatorcontrib>Kim, Seok Bae</creatorcontrib><creatorcontrib>Grant, Paul R.</creatorcontrib><creatorcontrib>Pappo, Orit</creatorcontrib><creatorcontrib>Spigelman, Mark</creatorcontrib><creatorcontrib>Shouval, Daniel</creatorcontrib><title>Tracing hepatitis B virus to the 16th century in a Korean mummy</title><title>Hepatology (Baltimore, Md.)</title><addtitle>Hepatology</addtitle><description>A rare find of a mummified child from the 16th century AD, in Korea, with relatively preserved organs, enabled a search for ancient hepatitis B virus (aHBV) DNA sequences from laparoscopic‐derived liver biopsies. Analysis of the complete aHBV genome (3,215 base pairs) revealed a unique HBV genotype C2 (HBV/C2) sequence commonly spread in Southeast Asia, which probably represents an HBV that infected the Joseon Dynasty population in Korea. Comparison of the aHBV sequences with contemporary HBV/C2 DNA sequences revealed distinctive differences along four open reading frames. Genetic diversity between contemporary and recovered aHBV/C2 DNA may be the result of immunologic, environmental, and/or pharmacologic pressures. The calculated time of most recent common ancestor suggests that the Korean HBV sequence origin dates back at least 3,000 years and possibly as long as 100,000 years. This isolate most likely represents the earliest human HBV sequence that colonized Southeast Asia by human migration. Conclusion: This study describes the complete sequence of the oldest HBV isolate and the most ancient full viral genome known so far. (HEPATOLOGY 2012;56:1671–1680)</description><subject>Asian Continental Ancestry Group - genetics</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Deoxyribonucleic acid</subject><subject>Disease transmission</subject><subject>DNA</subject><subject>DNA, Viral - genetics</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Genetic Variation</subject><subject>Genome, Viral</subject><subject>Genomes</subject><subject>Hepatitis</subject><subject>Hepatitis B</subject><subject>Hepatitis B virus - genetics</subject><subject>Hepatitis B virus - isolation & purification</subject><subject>Hepatitis B, Chronic - history</subject><subject>Hepatitis B, Chronic - pathology</subject><subject>Hepatitis B, Chronic - virology</subject><subject>Hepatology</subject><subject>History, 16th Century</subject><subject>Humans</subject><subject>Korea</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Medical sciences</subject><subject>Mummies - virology</subject><subject>Phylogeny</subject><subject>Phylogeography</subject><subject>Sequence Analysis, DNA</subject><issn>0270-9139</issn><issn>1527-3350</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10F1LHDEUBuAgLbpaL_oHSqAI9WI0OZPPq9KK1VKxRbSF3oRMJtONnY81mbHuv2_qrgpCrwKH57wnvAi9puSAEgKHc784AK44bKAZ5SCLsuTkBZoRkKTQtNRbaDula0KIZqA20RaAoERrMUPvL6N1of-Fc4YdwxgS_ohvQ5wSHgc8zj2mYpxj5_txikscemzxlyF62-Nu6rrlK_SysW3yu-t3B119Or48Oi3Ovp58PvpwVjimJBS-qSXl3HpgjPPagawqUTHlBOR5rUCWrKmk0kww3xBZKVLXLo8VV3VDoNxB71a5izjcTD6NpgvJ-ba1vR-mZCgFwRWjWmX69hm9HqbY598ZWgJoJaWgWe2vlItDStE3ZhFDZ-PSUGL-tWpyI-a-1WzfrBOnqvP1o3yoMYO9NbDJ2baJtnchPTkhpAbJsjtcuT-h9cv_XzSnx98eTherjZBGf_e4YeNvI2QpuflxfmJ-ficX4hxySvkX5lmZow</recordid><startdate>201211</startdate><enddate>201211</enddate><creator>Kahila Bar-Gal, Gila</creator><creator>Kim, Myeung Ju</creator><creator>Klein, Athalia</creator><creator>Shin, Dong Hoon</creator><creator>Oh, Chang Seok</creator><creator>Kim, Jong Wan</creator><creator>Kim, Tae-Hyun</creator><creator>Kim, Seok Bae</creator><creator>Grant, Paul R.</creator><creator>Pappo, Orit</creator><creator>Spigelman, Mark</creator><creator>Shouval, Daniel</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley</general><general>Wolters Kluwer Health, Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201211</creationdate><title>Tracing hepatitis B virus to the 16th century in a Korean mummy</title><author>Kahila Bar-Gal, Gila ; Kim, Myeung Ju ; Klein, Athalia ; Shin, Dong Hoon ; Oh, Chang Seok ; Kim, Jong Wan ; Kim, Tae-Hyun ; Kim, Seok Bae ; Grant, Paul R. ; Pappo, Orit ; Spigelman, Mark ; Shouval, Daniel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4872-efd7155ae24455dc27bb6b48c62715d82734fb789464ef07b80ddc827858df023</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Asian Continental Ancestry Group - genetics</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Deoxyribonucleic acid</topic><topic>Disease transmission</topic><topic>DNA</topic><topic>DNA, Viral - genetics</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Genetic Variation</topic><topic>Genome, Viral</topic><topic>Genomes</topic><topic>Hepatitis</topic><topic>Hepatitis B</topic><topic>Hepatitis B virus - genetics</topic><topic>Hepatitis B virus - isolation & purification</topic><topic>Hepatitis B, Chronic - history</topic><topic>Hepatitis B, Chronic - pathology</topic><topic>Hepatitis B, Chronic - virology</topic><topic>Hepatology</topic><topic>History, 16th Century</topic><topic>Humans</topic><topic>Korea</topic><topic>Liver. Biliary tract. Portal circulation. 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Analysis of the complete aHBV genome (3,215 base pairs) revealed a unique HBV genotype C2 (HBV/C2) sequence commonly spread in Southeast Asia, which probably represents an HBV that infected the Joseon Dynasty population in Korea. Comparison of the aHBV sequences with contemporary HBV/C2 DNA sequences revealed distinctive differences along four open reading frames. Genetic diversity between contemporary and recovered aHBV/C2 DNA may be the result of immunologic, environmental, and/or pharmacologic pressures. The calculated time of most recent common ancestor suggests that the Korean HBV sequence origin dates back at least 3,000 years and possibly as long as 100,000 years. This isolate most likely represents the earliest human HBV sequence that colonized Southeast Asia by human migration. Conclusion: This study describes the complete sequence of the oldest HBV isolate and the most ancient full viral genome known so far. (HEPATOLOGY 2012;56:1671–1680)</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>22610996</pmid><doi>10.1002/hep.25852</doi><tpages>10</tpages></addata></record> |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Wiley Online Library All Journals |
| subjects | Asian Continental Ancestry Group - genetics Biological and medical sciences Child Deoxyribonucleic acid Disease transmission DNA DNA, Viral - genetics Gastroenterology. Liver. Pancreas. Abdomen Genetic Variation Genome, Viral Genomes Hepatitis Hepatitis B Hepatitis B virus - genetics Hepatitis B virus - isolation & purification Hepatitis B, Chronic - history Hepatitis B, Chronic - pathology Hepatitis B, Chronic - virology Hepatology History, 16th Century Humans Korea Liver. Biliary tract. Portal circulation. Exocrine pancreas Medical sciences Mummies - virology Phylogeny Phylogeography Sequence Analysis, DNA |
| title | Tracing hepatitis B virus to the 16th century in a Korean mummy |
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