Broad band UVA: a possible reliable alternative to PUVA in the treatment of early-stage mycosis fungoides
Summary UVA1 phototherapy was found to induce marked improvement in skin lesions of patients with stages IA and IB mycosis fungoides (MF). Broad band UVA (BB‐UVA) is composed of 80.1% UVA1, with similar mechanisms of action. Our aim was to evaluate the efficacy of BB‐UVA in the treatment of early‐st...
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| Veröffentlicht in: | Photodermatology, photoimmunology & photomedicine photoimmunology & photomedicine, 2012-10, Vol.28 (5), p.274-277 |
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| creator | El Mofty, Medhat Ramadan, Shahira Fawzy, Marwa M. Hegazy, Rehab A. Sayed, Safinaz |
| description | Summary
UVA1 phototherapy was found to induce marked improvement in skin lesions of patients with stages IA and IB mycosis fungoides (MF). Broad band UVA (BB‐UVA) is composed of 80.1% UVA1, with similar mechanisms of action. Our aim was to evaluate the efficacy of BB‐UVA in the treatment of early‐stage MF. Thirty patients with early stage MF were included. They were divided into two equal groups receiving either BB‐UVA at 20 J/cm2/ session or PUVA three times/week for 40 sessions. Clinical and histopathological evaluations were performed before and after therapy in addition to immunohistochemical measurement of CD4+ cells and Bcl‐2. Patients were followed up for an average duration of 36 months. Comparable clinical and histopathological improvement was noted in MF patients in both groups. Clinical improvement graded ‘Excellent’ was achieved in 33% of patients in the BB‐UVA versus 13.3% in the psoralen and UVA (PUVA) group. Long‐term follow‐up indicated superiority of BB‐UVA over PUVA. BB‐UVA group showed a more rapid clearance rate, shorter time to achieve complete clearance, a longer disease‐free interval and lower relapse rate. The use of BB‐UVA in the treatment of early‐stage MF is comparable or even superior to PUVA regarding efficacy and remission periods. |
| doi_str_mv | 10.1111/j.1600-0781.2012.00690.x |
| format | Article |
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UVA1 phototherapy was found to induce marked improvement in skin lesions of patients with stages IA and IB mycosis fungoides (MF). Broad band UVA (BB‐UVA) is composed of 80.1% UVA1, with similar mechanisms of action. Our aim was to evaluate the efficacy of BB‐UVA in the treatment of early‐stage MF. Thirty patients with early stage MF were included. They were divided into two equal groups receiving either BB‐UVA at 20 J/cm2/ session or PUVA three times/week for 40 sessions. Clinical and histopathological evaluations were performed before and after therapy in addition to immunohistochemical measurement of CD4+ cells and Bcl‐2. Patients were followed up for an average duration of 36 months. Comparable clinical and histopathological improvement was noted in MF patients in both groups. Clinical improvement graded ‘Excellent’ was achieved in 33% of patients in the BB‐UVA versus 13.3% in the psoralen and UVA (PUVA) group. Long‐term follow‐up indicated superiority of BB‐UVA over PUVA. BB‐UVA group showed a more rapid clearance rate, shorter time to achieve complete clearance, a longer disease‐free interval and lower relapse rate. The use of BB‐UVA in the treatment of early‐stage MF is comparable or even superior to PUVA regarding efficacy and remission periods.</description><identifier>ISSN: 0905-4383</identifier><identifier>EISSN: 1600-0781</identifier><identifier>DOI: 10.1111/j.1600-0781.2012.00690.x</identifier><identifier>PMID: 22971197</identifier><language>eng</language><publisher>Oxford: Blackwell Publishing Ltd</publisher><subject>Adult ; Bcl-2 protein ; BCL2 ; Biological and medical sciences ; broad band-UVA ; CD4 antigen ; CD4 Antigens - metabolism ; Dermatology ; Female ; Follow-Up Studies ; Hematologic and hematopoietic diseases ; Humans ; Immunohistochemistry ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Male ; Medical sciences ; Middle Aged ; Mycosis fungoides ; Mycosis Fungoides - drug therapy ; Mycosis Fungoides - metabolism ; Mycosis Fungoides - pathology ; Mycosis Fungoides - radiotherapy ; Phototherapy ; Pilot Projects ; Proto-Oncogene Proteins c-bcl-2 - metabolism ; psoralen ; PUVA ; PUVA Therapy - methods ; Remission ; Remission Induction ; Skin diseases ; Skin Neoplasms - drug therapy ; Skin Neoplasms - metabolism ; Skin Neoplasms - pathology ; Skin Neoplasms - radiotherapy ; Ultraviolet Therapy - methods ; UVA1</subject><ispartof>Photodermatology, photoimmunology & photomedicine, 2012-10, Vol.28 (5), p.274-277</ispartof><rights>2012 John Wiley & Sons A/S</rights><rights>2015 INIST-CNRS</rights><rights>2012 John Wiley & Sons A/S.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4700-4e81d291f9c583d9d82f35a7078ad53ff2b04461e76e0c7416be820c9ba6409d3</citedby><cites>FETCH-LOGICAL-c4700-4e81d291f9c583d9d82f35a7078ad53ff2b04461e76e0c7416be820c9ba6409d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1600-0781.2012.00690.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1600-0781.2012.00690.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26362873$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22971197$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>El Mofty, Medhat</creatorcontrib><creatorcontrib>Ramadan, Shahira</creatorcontrib><creatorcontrib>Fawzy, Marwa M.</creatorcontrib><creatorcontrib>Hegazy, Rehab A.</creatorcontrib><creatorcontrib>Sayed, Safinaz</creatorcontrib><title>Broad band UVA: a possible reliable alternative to PUVA in the treatment of early-stage mycosis fungoides</title><title>Photodermatology, photoimmunology & photomedicine</title><addtitle>Photodermatol. Photoimmunol. Photomed</addtitle><description>Summary
UVA1 phototherapy was found to induce marked improvement in skin lesions of patients with stages IA and IB mycosis fungoides (MF). Broad band UVA (BB‐UVA) is composed of 80.1% UVA1, with similar mechanisms of action. Our aim was to evaluate the efficacy of BB‐UVA in the treatment of early‐stage MF. Thirty patients with early stage MF were included. They were divided into two equal groups receiving either BB‐UVA at 20 J/cm2/ session or PUVA three times/week for 40 sessions. Clinical and histopathological evaluations were performed before and after therapy in addition to immunohistochemical measurement of CD4+ cells and Bcl‐2. Patients were followed up for an average duration of 36 months. Comparable clinical and histopathological improvement was noted in MF patients in both groups. Clinical improvement graded ‘Excellent’ was achieved in 33% of patients in the BB‐UVA versus 13.3% in the psoralen and UVA (PUVA) group. Long‐term follow‐up indicated superiority of BB‐UVA over PUVA. BB‐UVA group showed a more rapid clearance rate, shorter time to achieve complete clearance, a longer disease‐free interval and lower relapse rate. The use of BB‐UVA in the treatment of early‐stage MF is comparable or even superior to PUVA regarding efficacy and remission periods.</description><subject>Adult</subject><subject>Bcl-2 protein</subject><subject>BCL2</subject><subject>Biological and medical sciences</subject><subject>broad band-UVA</subject><subject>CD4 antigen</subject><subject>CD4 Antigens - metabolism</subject><subject>Dermatology</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mycosis fungoides</subject><subject>Mycosis Fungoides - drug therapy</subject><subject>Mycosis Fungoides - metabolism</subject><subject>Mycosis Fungoides - pathology</subject><subject>Mycosis Fungoides - radiotherapy</subject><subject>Phototherapy</subject><subject>Pilot Projects</subject><subject>Proto-Oncogene Proteins c-bcl-2 - metabolism</subject><subject>psoralen</subject><subject>PUVA</subject><subject>PUVA Therapy - methods</subject><subject>Remission</subject><subject>Remission Induction</subject><subject>Skin diseases</subject><subject>Skin Neoplasms - drug therapy</subject><subject>Skin Neoplasms - metabolism</subject><subject>Skin Neoplasms - pathology</subject><subject>Skin Neoplasms - radiotherapy</subject><subject>Ultraviolet Therapy - methods</subject><subject>UVA1</subject><issn>0905-4383</issn><issn>1600-0781</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU-P0zAQxS0EYkvhKyBfkLgkjO04tpE47K7YP9IKKrELR8tJJotLmnTtFNpvj7Mt5Qi-eCz_nv1mHiGUQc7SerfMWQmQgdIs58B4DlAayLdPyOx48ZTMwIDMCqHFCXkR4xIAigLYc3LCuVGMGTUj_iwMrqGV6xt69_X0PXV0PcToqw5pwM67qXDdiKF3o_-JdBzoIoHU93T8no4B3bjCfqRDS9GFbpfF0d0jXe3qIfpI201_P_gG40vyrHVdxFeHfU7uLj7enl9lN58vr89Pb7K6UMl6gZo13LDW1FKLxjSat0I6lVpyjRRty6vURclQlQi1KlhZoeZQm8qVBZhGzMnb_bvrMDxsMI525WONXed6HDbRMsYlL0EV_N8oCKO1kcnInOg9Woc0noCtXQe_cmGXIDtlYpd2Gr2dRm-nTOxjJnabpK8Pv2yqFTZH4Z8QEvDmALhYu64Nrq99_MuVouRaicR92HO_fIe7_zZgF1eLRaqSPtvrfRxxe9S78MOWSihpv326tCDPLr7cSmmN-A1l07Td</recordid><startdate>201210</startdate><enddate>201210</enddate><creator>El Mofty, Medhat</creator><creator>Ramadan, Shahira</creator><creator>Fawzy, Marwa M.</creator><creator>Hegazy, Rehab A.</creator><creator>Sayed, Safinaz</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope><scope>M7N</scope></search><sort><creationdate>201210</creationdate><title>Broad band UVA: a possible reliable alternative to PUVA in the treatment of early-stage mycosis fungoides</title><author>El Mofty, Medhat ; Ramadan, Shahira ; Fawzy, Marwa M. ; Hegazy, Rehab A. ; Sayed, Safinaz</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4700-4e81d291f9c583d9d82f35a7078ad53ff2b04461e76e0c7416be820c9ba6409d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Bcl-2 protein</topic><topic>BCL2</topic><topic>Biological and medical sciences</topic><topic>broad band-UVA</topic><topic>CD4 antigen</topic><topic>CD4 Antigens - metabolism</topic><topic>Dermatology</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mycosis fungoides</topic><topic>Mycosis Fungoides - drug therapy</topic><topic>Mycosis Fungoides - metabolism</topic><topic>Mycosis Fungoides - pathology</topic><topic>Mycosis Fungoides - radiotherapy</topic><topic>Phototherapy</topic><topic>Pilot Projects</topic><topic>Proto-Oncogene Proteins c-bcl-2 - metabolism</topic><topic>psoralen</topic><topic>PUVA</topic><topic>PUVA Therapy - methods</topic><topic>Remission</topic><topic>Remission Induction</topic><topic>Skin diseases</topic><topic>Skin Neoplasms - drug therapy</topic><topic>Skin Neoplasms - metabolism</topic><topic>Skin Neoplasms - pathology</topic><topic>Skin Neoplasms - radiotherapy</topic><topic>Ultraviolet Therapy - methods</topic><topic>UVA1</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>El Mofty, Medhat</creatorcontrib><creatorcontrib>Ramadan, Shahira</creatorcontrib><creatorcontrib>Fawzy, Marwa M.</creatorcontrib><creatorcontrib>Hegazy, Rehab A.</creatorcontrib><creatorcontrib>Sayed, Safinaz</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><jtitle>Photodermatology, photoimmunology & photomedicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>El Mofty, Medhat</au><au>Ramadan, Shahira</au><au>Fawzy, Marwa M.</au><au>Hegazy, Rehab A.</au><au>Sayed, Safinaz</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Broad band UVA: a possible reliable alternative to PUVA in the treatment of early-stage mycosis fungoides</atitle><jtitle>Photodermatology, photoimmunology & photomedicine</jtitle><addtitle>Photodermatol. Photoimmunol. Photomed</addtitle><date>2012-10</date><risdate>2012</risdate><volume>28</volume><issue>5</issue><spage>274</spage><epage>277</epage><pages>274-277</pages><issn>0905-4383</issn><eissn>1600-0781</eissn><abstract>Summary
UVA1 phototherapy was found to induce marked improvement in skin lesions of patients with stages IA and IB mycosis fungoides (MF). Broad band UVA (BB‐UVA) is composed of 80.1% UVA1, with similar mechanisms of action. Our aim was to evaluate the efficacy of BB‐UVA in the treatment of early‐stage MF. Thirty patients with early stage MF were included. They were divided into two equal groups receiving either BB‐UVA at 20 J/cm2/ session or PUVA three times/week for 40 sessions. Clinical and histopathological evaluations were performed before and after therapy in addition to immunohistochemical measurement of CD4+ cells and Bcl‐2. Patients were followed up for an average duration of 36 months. Comparable clinical and histopathological improvement was noted in MF patients in both groups. Clinical improvement graded ‘Excellent’ was achieved in 33% of patients in the BB‐UVA versus 13.3% in the psoralen and UVA (PUVA) group. Long‐term follow‐up indicated superiority of BB‐UVA over PUVA. BB‐UVA group showed a more rapid clearance rate, shorter time to achieve complete clearance, a longer disease‐free interval and lower relapse rate. The use of BB‐UVA in the treatment of early‐stage MF is comparable or even superior to PUVA regarding efficacy and remission periods.</abstract><cop>Oxford</cop><pub>Blackwell Publishing Ltd</pub><pmid>22971197</pmid><doi>10.1111/j.1600-0781.2012.00690.x</doi><tpages>4</tpages></addata></record> |
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| subjects | Adult Bcl-2 protein BCL2 Biological and medical sciences broad band-UVA CD4 antigen CD4 Antigens - metabolism Dermatology Female Follow-Up Studies Hematologic and hematopoietic diseases Humans Immunohistochemistry Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Male Medical sciences Middle Aged Mycosis fungoides Mycosis Fungoides - drug therapy Mycosis Fungoides - metabolism Mycosis Fungoides - pathology Mycosis Fungoides - radiotherapy Phototherapy Pilot Projects Proto-Oncogene Proteins c-bcl-2 - metabolism psoralen PUVA PUVA Therapy - methods Remission Remission Induction Skin diseases Skin Neoplasms - drug therapy Skin Neoplasms - metabolism Skin Neoplasms - pathology Skin Neoplasms - radiotherapy Ultraviolet Therapy - methods UVA1 |
| title | Broad band UVA: a possible reliable alternative to PUVA in the treatment of early-stage mycosis fungoides |
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