Leptin-mediated reactive oxygen species production does not significantly affect primary mouse hepatocyte functions in vitro

AIMDirect and indirect effects of leptin on hepatic stellate cells (HSCs) have been documented in the literature, whereas little is known about leptin’s actions on hepatocytes. Leptin mediates its profibrogenic and proinflammatory effects on HSCs in part through the production of intracellular react...

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Veröffentlicht in:	European journal of gastroenterology & hepatology 2012-12, Vol.24 (12), p.1370-1380
Hauptverfasser:	Schroyen, Ben, Guimarães, Eduardo L, Dollé, Laurent, Coulon, Stephanie, Empsen, Christophe, Nyssen, Marc, Geerts, Anja, Colle, Isabelle, Geerts, Albert, van Grunsven, Leo A
Format:	Artikel
Sprache:	eng
Schlagworte:	Albumins - metabolism Animals Apoptosis Biological and medical sciences Blotting, Western Cells, Cultured Cytochrome P-450 CYP1A2 - metabolism Enzyme Inhibitors - pharmacology Gastroenterology. Liver. Pancreas. Abdomen Heme Oxygenase-1 - genetics Heme Oxygenase-1 - metabolism Hepatocytes - drug effects Hepatocytes - metabolism Hepatocytes - pathology Janus Kinase 2 - antagonists & inhibitors Janus Kinase 2 - metabolism Leptin - metabolism MAP Kinase Kinase 1 - antagonists & inhibitors MAP Kinase Kinase 1 - metabolism Medical sciences Membrane Proteins - genetics Membrane Proteins - metabolism Mice Mice, Inbred BALB C Mice, Inbred C57BL NADPH Oxidases - antagonists & inhibitors NADPH Oxidases - metabolism Oxidative Stress - drug effects Protein Isoforms Reactive Oxygen Species - metabolism Real-Time Polymerase Chain Reaction Receptors, Leptin - genetics Receptors, Leptin - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism Signal Transduction Time Factors Urea - metabolism
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