Loperamide Effects on Anxiety Level and Feeding Behavior in Rats. Role of Vagal Afferentation
We investigated the role of vagal afferentation in the interaction of the peripheral and central parts of the endogenous opioid system, in the mechanisms of sensorial satiation and anxiety in rats. It has been established that vagotomized rats spent less time in open arm of the plus-maze in comparis...
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| Veröffentlicht in: | Bulletin of experimental biology and medicine 2012-09, Vol.153 (5), p.717-719 |
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| creator | Sudakov, S. K. Bashkatova, V. G. Kolpakov, A. A. Chernyaeva, N. N. |
| description | We investigated the role of vagal afferentation in the interaction of the peripheral and central parts of the endogenous opioid system, in the mechanisms of sensorial satiation and anxiety in rats. It has been established that vagotomized rats spent less time in open arm of the plus-maze in comparison with sham-operated animals. Peripheral administration of μ-opioid receptor agonist loperamide was shown to reduce anxiety level in sham-operated rats and had no effect on this parameter in vagotomized animals. Testing in a PhenoMaster module system showed that loperamide administration suppressed feeding behavior in sham-operated animals and partially suppressed it in vagotomized animals. Vagotomy virtually completely blocked the anxiolytic effect of loperamide and partially blocked the anorexigenic effect of the μ-opioid receptor agonist. |
| doi_str_mv | 10.1007/s10517-012-1808-3 |
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Testing in a PhenoMaster module system showed that loperamide administration suppressed feeding behavior in sham-operated animals and partially suppressed it in vagotomized animals. 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K.</creatorcontrib><creatorcontrib>Bashkatova, V. G.</creatorcontrib><creatorcontrib>Kolpakov, A. A.</creatorcontrib><creatorcontrib>Chernyaeva, N. N.</creatorcontrib><title>Loperamide Effects on Anxiety Level and Feeding Behavior in Rats. Role of Vagal Afferentation</title><title>Bulletin of experimental biology and medicine</title><addtitle>Bull Exp Biol Med</addtitle><addtitle>Bull Exp Biol Med</addtitle><description>We investigated the role of vagal afferentation in the interaction of the peripheral and central parts of the endogenous opioid system, in the mechanisms of sensorial satiation and anxiety in rats. It has been established that vagotomized rats spent less time in open arm of the plus-maze in comparison with sham-operated animals. Peripheral administration of μ-opioid receptor agonist loperamide was shown to reduce anxiety level in sham-operated rats and had no effect on this parameter in vagotomized animals. Testing in a PhenoMaster module system showed that loperamide administration suppressed feeding behavior in sham-operated animals and partially suppressed it in vagotomized animals. Vagotomy virtually completely blocked the anxiolytic effect of loperamide and partially blocked the anorexigenic effect of the μ-opioid receptor agonist.</description><subject>Analysis of Variance</subject><subject>Animal behavior</subject><subject>Animals</subject><subject>Anxiety - drug therapy</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cell Biology</subject><subject>Feeding Behavior - drug effects</subject><subject>Internal Medicine</subject><subject>Laboratory Medicine</subject><subject>Loperamide</subject><subject>Loperamide - pharmacology</subject><subject>Male</subject><subject>Maze Learning - drug effects</subject><subject>Pathology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Receptors, Opioid - agonists</subject><subject>Tranquilizing drugs</subject><subject>Vagotomy</subject><subject>Vagus Nerve - metabolism</subject><issn>0007-4888</issn><issn>1573-8221</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kVFrFDEUhYModm39Ab5IQJC-zJqbmcxkH7elVWFBKNY3CZnJzW7KTLImM8X--2bYqq0oCYSb-51Dbg4hb4AtgbHmQwImoCkY8AIkk0X5jCxANGUhOYfnZMEyVFRSyiPyKqWbuWQ1vCRHvAQoed0syPdN2GPUgzNIL6zFbkw0eLr2Px2Od3SDt9hT7Q29RDTOb-kZ7vStC5E6T6_0mJb0KvRIg6Xf9Fb3dJ1NIvpRjy74E_LC6j7h64fzmFxfXnw9_1Rsvnz8fL7eFJ0o67FoJG8MA6uFabnhq67CumLIRC1qtqpQ11wY0_DW8laDaGuQuV1JY6XOGl4ek9OD7z6GHxOmUQ0uddj32mOYkgLgggsm5Cqj7_5Cb8IUfX5dpqBaVTzvP1QeCZXzNoxRd7OpWpeSZbNKlJla_oPKy-DguuDRunz_RPD-kWCHuh93KfTT_FfpKQgHsIshpYhW7aMbdLxTwNScvTpkr3L2as5ezZq3D5NN7YDmt-JX2BngByDllt9ifDT6f13vAXoktMw</recordid><startdate>20120901</startdate><enddate>20120901</enddate><creator>Sudakov, S. 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Role of Vagal Afferentation</title><author>Sudakov, S. K. ; Bashkatova, V. G. ; Kolpakov, A. A. ; Chernyaeva, N. N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c536t-7827d01fa5db2d29c4e640e05656094ea625dd72bf2ba15b61840e48df8aa5d23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Analysis of Variance</topic><topic>Animal behavior</topic><topic>Animals</topic><topic>Anxiety - drug therapy</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cell Biology</topic><topic>Feeding Behavior - drug effects</topic><topic>Internal Medicine</topic><topic>Laboratory Medicine</topic><topic>Loperamide</topic><topic>Loperamide - pharmacology</topic><topic>Male</topic><topic>Maze Learning - drug effects</topic><topic>Pathology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Receptors, Opioid - agonists</topic><topic>Tranquilizing drugs</topic><topic>Vagotomy</topic><topic>Vagus Nerve - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sudakov, S. 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| subjects | Analysis of Variance Animal behavior Animals Anxiety - drug therapy Biomedical and Life Sciences Biomedicine Cell Biology Feeding Behavior - drug effects Internal Medicine Laboratory Medicine Loperamide Loperamide - pharmacology Male Maze Learning - drug effects Pathology Rats Rats, Wistar Receptors, Opioid - agonists Tranquilizing drugs Vagotomy Vagus Nerve - metabolism |
| title | Loperamide Effects on Anxiety Level and Feeding Behavior in Rats. Role of Vagal Afferentation |
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