Development of cell-active N6-methyladenosine RNA demethylase FTO inhibitor

The direct nucleic acid repair dioxygenase FTO is an enzyme that demethylates N(6)-methyladenosine (m(6)A) residues in mRNA in vitro and inside cells. FTO is the first RNA demethylase discovered that also serves a major regulatory function in mammals. Together with structure-based virtual screening...

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Veröffentlicht in:	Journal of the American Chemical Society 2012-10, Vol.134 (43), p.17963-17971
Hauptverfasser:	Chen, Baoen, Ye, Fei, Yu, Lu, Jia, Guifang, Huang, Xiaotian, Zhang, Xueju, Peng, Shuying, Chen, Kai, Wang, Meining, Gong, Shouze, Zhang, Ruihan, Yin, Jinya, Li, Haiyan, Yang, Yiming, Liu, Hong, Zhang, Jiwen, Zhang, Haiyan, Zhang, Ao, Jiang, Hualiang, Luo, Cheng, Yang, Cai-Guang
Format:	Artikel
Sprache:	eng
Schlagworte:	Alpha-Ketoglutarate-Dependent Dioxygenase FTO Anthraquinones - chemical synthesis Anthraquinones - chemistry Anthraquinones - pharmacology Cell Line Drug Evaluation, Preclinical Humans Kinetics Models, Molecular Molecular Structure Molecular Weight Proteins - antagonists & inhibitors Proteins - metabolism Structure-Activity Relationship
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