Impact of amiodarone and cisapride on simulated human ventricular electrophysiology and electrocardiograms

Amiodarone and cisapride are both known to prolong the QT interval, yet the two drugs have different effects on arrhythmia. Cisapride can cause torsades de pointes while amiodarone is found to be anti-arrhythmic. A computational model was used to investigate the action of these two drugs. In a bioph...

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Veröffentlicht in:	Europace (London, England) England), 2012-11, Vol.14 Suppl 5 (suppl 5), p.v90-v96
Hauptverfasser:	Wilhelms, Mathias, Rombach, Christian, Scholz, Eberhard P, Dössel, Olaf, Seemann, Gunnar
Format:	Artikel
Sprache:	eng
Schlagworte:	Amiodarone - administration & dosage Anti-Arrhythmia Agents - administration & dosage Arrhythmias, Cardiac - drug therapy Arrhythmias, Cardiac - physiopathology Cisapride - administration & dosage Computer Simulation Drug Therapy, Computer-Assisted - methods Electrocardiography - drug effects Heart Conduction System - drug effects Heart Conduction System - physiopathology Heart Ventricles - drug effects Heart Ventricles - physiopathology Humans Models, Cardiovascular Serotonin Receptor Agonists - administration & dosage
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