Sorafenib in patients with metastatic gastrointestinal stromal tumors who failed two or more prior tyrosine kinase inhibitors: a phase II study of Korean gastrointestinal stromal tumors study group

Summary Purpose To evaluated the efficacy and safety of sorafenib in patients with advanced gastrointestinal stromal tumors (GIST) who failed to previous standard treatments. Experimental Design Thirty-one patients with measurable metastatic GIST who failed both imatinib and sunitinib were accrued....

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Veröffentlicht in:	Investigational new drugs 2012-12, Vol.30 (6), p.2377-2383
Hauptverfasser:	Park, S. H., Ryu, M. H., Ryoo, B. Y., Im, S. A., Kwon, H. C., Lee, S. S., Park, S. R., Kang, B. Y., Kang, Y. K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Abdomen Adult Aged Antineoplastic Agents - therapeutic use Asian Continental Ancestry Group Cancer therapies Chemotherapy Disease control Drug dosages Drug Resistance, Neoplasm - drug effects Female Gastrointestinal cancer Gastrointestinal Neoplasms - drug therapy Gastrointestinal Neoplasms - genetics Gastrointestinal Stromal Tumors - drug therapy Gastrointestinal Stromal Tumors - genetics Genotype Hematology Hormone replacement therapy Hospitals Humans Internal medicine Laboratories Liver cancer Male Medicine Medicine & Public Health Metastasis Middle Aged Mutation Niacinamide - analogs & derivatives Niacinamide - therapeutic use Oncology Patients Pharmacology/Toxicology Phase II Studies Phenylurea Compounds - therapeutic use Protein Kinase Inhibitors - therapeutic use Proto-Oncogene Proteins c-kit - genetics Receptor, Platelet-Derived Growth Factor alpha - genetics Response rates Toxicity Treatment Outcome Tumors
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