Notes on the use of urine-CCA dipsticks for detection of intestinal schistosomiasis in preschool children
Urine-dipstick diagnostic tests that detect schistosome circulating cathodic antigen (CCA) have the potential to provide more sensitive and rapid testing for intestinal schistosomiasis in field-based surveys; this is especially so when examining preschool children, from whom it may be difficult to o...
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| Veröffentlicht in: | Transactions of the Royal Society of Tropical Medicine and Hygiene 2012-10, Vol.106 (10), p.619-622 |
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| container_title | Transactions of the Royal Society of Tropical Medicine and Hygiene |
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| creator | Navaratnam, A.M.D. Mutumba-Nakalembe, M.J. Stothard, J.R. Kabatereine, N.B. Fenwick, A. Sousa-Figueiredo, J.C. |
| description | Urine-dipstick diagnostic tests that detect schistosome circulating cathodic antigen (CCA) have the potential to provide more sensitive and rapid testing for intestinal schistosomiasis in field-based surveys; this is especially so when examining preschool children, from whom it may be difficult to obtain consecutive stool samples. To assess the performance of urine dipsticks, 569 preschool children from four villages along the shore of Lake Albert, Uganda, were screened for Schistosoma mansoni by Kato-Katz (K-K) examination of a single stool sample and CCA urine dipsticks. The prevalence of infection was 32.2% by K-K and 40.0% by CCA tests. Sensitivity and specificity were influenced by whether ‘trace’ results from the CCA test were characterised as positive or negative for infection with S. mansoni; ambiguities around this issue need to be resolved. Nevertheless, the CCA test showed particular promise for routine epidemiological screening in this setting. |
| doi_str_mv | 10.1016/j.trstmh.2012.06.010 |
| format | Article |
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To assess the performance of urine dipsticks, 569 preschool children from four villages along the shore of Lake Albert, Uganda, were screened for Schistosoma mansoni by Kato-Katz (K-K) examination of a single stool sample and CCA urine dipsticks. The prevalence of infection was 32.2% by K-K and 40.0% by CCA tests. Sensitivity and specificity were influenced by whether ‘trace’ results from the CCA test were characterised as positive or negative for infection with S. mansoni; ambiguities around this issue need to be resolved. 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To assess the performance of urine dipsticks, 569 preschool children from four villages along the shore of Lake Albert, Uganda, were screened for Schistosoma mansoni by Kato-Katz (K-K) examination of a single stool sample and CCA urine dipsticks. The prevalence of infection was 32.2% by K-K and 40.0% by CCA tests. Sensitivity and specificity were influenced by whether ‘trace’ results from the CCA test were characterised as positive or negative for infection with S. mansoni; ambiguities around this issue need to be resolved. Nevertheless, the CCA test showed particular promise for routine epidemiological screening in this setting.</description><subject>Animals</subject><subject>Antigens, Helminth - immunology</subject><subject>Antigens, Helminth - urine</subject><subject>Biological and medical sciences</subject><subject>Child, Preschool</subject><subject>Control programmes</subject><subject>Diagnostic scores</subject><subject>Diagnostic tests</subject><subject>Diseases caused by trematodes</subject><subject>Feces - parasitology</subject><subject>Female</subject><subject>General aspects</subject><subject>Glycoproteins - immunology</subject><subject>Glycoproteins - urine</subject><subject>Helminth Proteins - immunology</subject><subject>Helminth Proteins - urine</subject><subject>Helminthic diseases</subject><subject>Humans</subject><subject>Infant</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neglected tropical diseases</subject><subject>Parasite Egg Count</subject><subject>Parasitic diseases</subject><subject>Prevalence</subject><subject>Rapid mapping</subject><subject>Reagent Strips</subject><subject>Schistosoma mansoni</subject><subject>Schistosoma mansoni - immunology</subject><subject>Schistosoma mansoni - isolation & purification</subject><subject>Schistosomiases</subject><subject>Schistosomiasis mansoni - epidemiology</subject><subject>Schistosomiasis mansoni - immunology</subject><subject>Schistosomiasis mansoni - urine</subject><subject>Sensitivity and Specificity</subject><subject>Uganda - epidemiology</subject><subject>Urine - chemistry</subject><subject>Urine - parasitology</subject><issn>0035-9203</issn><issn>1878-3503</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUuLFDEURoMoTs_oPxDJRnBTNXlU6rERhsYXDLrRdUglN3Taqkqbmxrw35umWt2pEAjknu_eJIeQF5zVnPH29ljnhHk-1IJxUbO2Zpw9Ijved30lFZOPyY4xqapBMHlFrhGPjAnF1fCUXAnRq140fEfCp5gBaVxoPgBdEWj0dE1hgWq_v6MunDAH-w2pj4k6yGBzKHCBwlKCOSxmomgPAXPEOAeDAUuJnhKU0xgnWmqTS7A8I0-8mRCeX_Yb8vXd2y_7D9X95_cf93f3lW1alauRK-nb0XRjywznBpy3nre95J2VtvGu87zhrerHxtuGCTDjAE4628l-7KSXN-T11veU4ve1XFHPAS1Mk1kgrqg5F6o8XQn1b5TJoSzenNFmQ22KiAm8PqUwm_SjQPrsQx_15kOffWjW6uKjxF5eJqzjDO536JeAAry6AAatmXwyiw34h2tl33TDef7txsX19L-j32wJKJ_9ECBptAEWCy6kYlG7GP7e4CeSjbuK</recordid><startdate>20121001</startdate><enddate>20121001</enddate><creator>Navaratnam, A.M.D.</creator><creator>Mutumba-Nakalembe, M.J.</creator><creator>Stothard, J.R.</creator><creator>Kabatereine, N.B.</creator><creator>Fenwick, A.</creator><creator>Sousa-Figueiredo, J.C.</creator><general>Elsevier Ltd</general><general>Royal Society of Tropical Medicine and Hygiene</general><general>Oxford University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T2</scope><scope>7U2</scope><scope>C1K</scope><scope>F1W</scope><scope>H95</scope><scope>H97</scope><scope>L.G</scope></search><sort><creationdate>20121001</creationdate><title>Notes on the use of urine-CCA dipsticks for detection of intestinal schistosomiasis in preschool children</title><author>Navaratnam, A.M.D. ; 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this is especially so when examining preschool children, from whom it may be difficult to obtain consecutive stool samples. To assess the performance of urine dipsticks, 569 preschool children from four villages along the shore of Lake Albert, Uganda, were screened for Schistosoma mansoni by Kato-Katz (K-K) examination of a single stool sample and CCA urine dipsticks. The prevalence of infection was 32.2% by K-K and 40.0% by CCA tests. Sensitivity and specificity were influenced by whether ‘trace’ results from the CCA test were characterised as positive or negative for infection with S. mansoni; ambiguities around this issue need to be resolved. Nevertheless, the CCA test showed particular promise for routine epidemiological screening in this setting.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>22858241</pmid><doi>10.1016/j.trstmh.2012.06.010</doi><tpages>4</tpages></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE |
| subjects | Animals Antigens, Helminth - immunology Antigens, Helminth - urine Biological and medical sciences Child, Preschool Control programmes Diagnostic scores Diagnostic tests Diseases caused by trematodes Feces - parasitology Female General aspects Glycoproteins - immunology Glycoproteins - urine Helminth Proteins - immunology Helminth Proteins - urine Helminthic diseases Humans Infant Infectious diseases Male Medical sciences Neglected tropical diseases Parasite Egg Count Parasitic diseases Prevalence Rapid mapping Reagent Strips Schistosoma mansoni Schistosoma mansoni - immunology Schistosoma mansoni - isolation & purification Schistosomiases Schistosomiasis mansoni - epidemiology Schistosomiasis mansoni - immunology Schistosomiasis mansoni - urine Sensitivity and Specificity Uganda - epidemiology Urine - chemistry Urine - parasitology |
| title | Notes on the use of urine-CCA dipsticks for detection of intestinal schistosomiasis in preschool children |
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