Hippocampal A-type current and Kv4.2 channel modulation by the sulfonylurea compound NS5806

We examined the effects of the sulfonylurea compound NS5806 on neuronal A-type channel function. Using whole-cell patch-clamp we studied the effects of NS5806 on the somatodendritic A-type current (ISA) in cultured hippocampal neurons and the currents mediated by Kv4.2 channels coexpressed with diff...

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Veröffentlicht in:	Neuropharmacology 2012-12, Vol.63 (8), p.1389-1403
Hauptverfasser:	Witzel, Katrin, Fischer, Paul, Bähring, Robert
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cells, Cultured Data Interpretation, Statistical Dipeptidyl-Peptidases and Tripeptidyl-Peptidases - drug effects Dipeptidyl-Peptidases and Tripeptidyl-Peptidases - metabolism Dipeptidyl-Peptidases and Tripeptidyl-Peptidases - physiology HEK293 Cells Hippocampus Hippocampus - drug effects Hippocampus - metabolism Humans In Vitro Techniques Inactivation Indexing in process Kinetics Kv Channel-Interacting Proteins - physiology Neurons - drug effects Neurons - metabolism Patch-Clamp Techniques Phenylurea Compounds - pharmacology Potassium channel Potassium Channel Blockers - pharmacology Primary culture Rats Rats, Wistar Shal Potassium Channels - drug effects Somatodendritic A-type current Tetrazoles - pharmacology Whole-cell patch-clamp
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