Hypothyroxinemia during pregnancy: the effect on neurodevelopment in the child
► A lack of iodine in the diet may result in the mother becoming iodine deficient, and subsequently hypothyroxinaemic. ► Maternal hypothyroxinemia has a detrimental effect on fetal brain development. ► Screening fT4 at 12 weeks could indicate a subgroup of women whose infants would benefit from an i...
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| Veröffentlicht in: | International journal of developmental neuroscience 2012-10, Vol.30 (6), p.435-438 |
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| container_title | International journal of developmental neuroscience |
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| creator | Suárez-Rodríguez, Marta Azcona-San Julián, Cristina Alzina de Aguilar, Valentín |
| description | ► A lack of iodine in the diet may result in the mother becoming iodine deficient, and subsequently hypothyroxinaemic. ► Maternal hypothyroxinemia has a detrimental effect on fetal brain development. ► Screening fT4 at 12 weeks could indicate a subgroup of women whose infants would benefit from an increase of maternal fT4.
Experimental studies have shown that maternal hypothyroxinemia during early pregnancy is associated with poor neurodevelopment in affected offspring.
The aim of this study was to assess the impact of maternal serum free T4 on psychomotor development of offspring.
The study involved 147 women in the third trimester (week 37) of pregnancy. TSH and free T4 serum levels were measured at 37 week gestation. The children were evaluated between 38 and 60 months of age by the McCarthy Scales of Children's Abilities.
54.4% of the women had a free T4 below the threshold of hypothyroxinemia. We find a significant effect of maternal hypothyroxinemia on the general cognitive index, and on perceptual-manipulative and memory coefficients. |
| doi_str_mv | 10.1016/j.ijdevneu.2012.07.004 |
| format | Article |
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Experimental studies have shown that maternal hypothyroxinemia during early pregnancy is associated with poor neurodevelopment in affected offspring.
The aim of this study was to assess the impact of maternal serum free T4 on psychomotor development of offspring.
The study involved 147 women in the third trimester (week 37) of pregnancy. TSH and free T4 serum levels were measured at 37 week gestation. The children were evaluated between 38 and 60 months of age by the McCarthy Scales of Children's Abilities.
54.4% of the women had a free T4 below the threshold of hypothyroxinemia. We find a significant effect of maternal hypothyroxinemia on the general cognitive index, and on perceptual-manipulative and memory coefficients.</description><identifier>ISSN: 0736-5748</identifier><identifier>EISSN: 1873-474X</identifier><identifier>DOI: 10.1016/j.ijdevneu.2012.07.004</identifier><identifier>PMID: 22877976</identifier><language>eng</language><publisher>United States: Elsevier Ltd</publisher><subject>Child, Preschool ; Cognition Disorders - etiology ; Developmental Disabilities - complications ; Developmental Disabilities - etiology ; Female ; Humans ; Hypothyroidism - physiopathology ; Hypothyroidism - urine ; Hypothyroxinemia ; Indexing in process ; Iodine - urine ; Iodine intake ; Male ; Neurodevelopment ; Pregnancy ; Pregnancy Trimester, First ; Prenatal Exposure Delayed Effects - physiopathology ; Prenatal Exposure Delayed Effects - urine ; Psychomotor Performance - physiology ; Retrospective Studies ; Thyroid Gland - physiopathology</subject><ispartof>International journal of developmental neuroscience, 2012-10, Vol.30 (6), p.435-438</ispartof><rights>2012 ISDN</rights><rights>Copyright © 2012 ISDN. Published by Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4674-f73ac960285a301f16371549b4a504e4e4d55614f010bf12654fbc118993d8c73</citedby><cites>FETCH-LOGICAL-c4674-f73ac960285a301f16371549b4a504e4e4d55614f010bf12654fbc118993d8c73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1016%2Fj.ijdevneu.2012.07.004$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1016%2Fj.ijdevneu.2012.07.004$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22877976$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Suárez-Rodríguez, Marta</creatorcontrib><creatorcontrib>Azcona-San Julián, Cristina</creatorcontrib><creatorcontrib>Alzina de Aguilar, Valentín</creatorcontrib><title>Hypothyroxinemia during pregnancy: the effect on neurodevelopment in the child</title><title>International journal of developmental neuroscience</title><addtitle>Int J Dev Neurosci</addtitle><description>► A lack of iodine in the diet may result in the mother becoming iodine deficient, and subsequently hypothyroxinaemic. ► Maternal hypothyroxinemia has a detrimental effect on fetal brain development. ► Screening fT4 at 12 weeks could indicate a subgroup of women whose infants would benefit from an increase of maternal fT4.
Experimental studies have shown that maternal hypothyroxinemia during early pregnancy is associated with poor neurodevelopment in affected offspring.
The aim of this study was to assess the impact of maternal serum free T4 on psychomotor development of offspring.
The study involved 147 women in the third trimester (week 37) of pregnancy. TSH and free T4 serum levels were measured at 37 week gestation. The children were evaluated between 38 and 60 months of age by the McCarthy Scales of Children's Abilities.
54.4% of the women had a free T4 below the threshold of hypothyroxinemia. We find a significant effect of maternal hypothyroxinemia on the general cognitive index, and on perceptual-manipulative and memory coefficients.</description><subject>Child, Preschool</subject><subject>Cognition Disorders - etiology</subject><subject>Developmental Disabilities - complications</subject><subject>Developmental Disabilities - etiology</subject><subject>Female</subject><subject>Humans</subject><subject>Hypothyroidism - physiopathology</subject><subject>Hypothyroidism - urine</subject><subject>Hypothyroxinemia</subject><subject>Indexing in process</subject><subject>Iodine - urine</subject><subject>Iodine intake</subject><subject>Male</subject><subject>Neurodevelopment</subject><subject>Pregnancy</subject><subject>Pregnancy Trimester, First</subject><subject>Prenatal Exposure Delayed Effects - physiopathology</subject><subject>Prenatal Exposure Delayed Effects - urine</subject><subject>Psychomotor Performance - physiology</subject><subject>Retrospective Studies</subject><subject>Thyroid Gland - physiopathology</subject><issn>0736-5748</issn><issn>1873-474X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU1v1DAQhi0EokvhL1Q5ckmw46-EE6hd6K6q5UIRNyvrjLteJXawk5b8e7yk5VpkS5ZGz8w7eozQBcEFwUR8OBb22MK9g6koMSkLLAuM2Qu0IpWkOZPs50u0wpKKnEtWnaE3MR4xxpxj9hqdlWUlZS3FCu2u58GPhzn439ZBb5usnYJ1d9kQ4M41Ts8fs_EAGRgDesy8y1Jk8CkaOj_04MbMur-EPtiufYtemaaL8O7xPUe3X9bfL6_zm29fN5efb3LNhGS5kbTRtcBlxRuKiSGCSsJZvWdNWhDSaTkXhBlM8N6QUnBm9pqQqq5pW2lJz9H7Ze4Q_K8J4qh6GzV0XePAT1ERUvKS1kLWz6OY1ukKwRMqFlQHH2MAo4Zg-ybMCVIn7eqonrSrk3aFpUraU-PFY8a076H91_bkOQGbBXiwHcz_OVZtr3bbzfZq_WO3vj3VsVzCPi2zIAm-txBU1BachtaG9Eeq9fa5ff8AgTSs1w</recordid><startdate>201210</startdate><enddate>201210</enddate><creator>Suárez-Rodríguez, Marta</creator><creator>Azcona-San Julián, Cristina</creator><creator>Alzina de Aguilar, Valentín</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>201210</creationdate><title>Hypothyroxinemia during pregnancy: the effect on neurodevelopment in the child</title><author>Suárez-Rodríguez, Marta ; Azcona-San Julián, Cristina ; Alzina de Aguilar, Valentín</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4674-f73ac960285a301f16371549b4a504e4e4d55614f010bf12654fbc118993d8c73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Child, Preschool</topic><topic>Cognition Disorders - etiology</topic><topic>Developmental Disabilities - complications</topic><topic>Developmental Disabilities - etiology</topic><topic>Female</topic><topic>Humans</topic><topic>Hypothyroidism - physiopathology</topic><topic>Hypothyroidism - urine</topic><topic>Hypothyroxinemia</topic><topic>Indexing in process</topic><topic>Iodine - urine</topic><topic>Iodine intake</topic><topic>Male</topic><topic>Neurodevelopment</topic><topic>Pregnancy</topic><topic>Pregnancy Trimester, First</topic><topic>Prenatal Exposure Delayed Effects - physiopathology</topic><topic>Prenatal Exposure Delayed Effects - urine</topic><topic>Psychomotor Performance - physiology</topic><topic>Retrospective Studies</topic><topic>Thyroid Gland - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Suárez-Rodríguez, Marta</creatorcontrib><creatorcontrib>Azcona-San Julián, Cristina</creatorcontrib><creatorcontrib>Alzina de Aguilar, Valentín</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>International journal of developmental neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Suárez-Rodríguez, Marta</au><au>Azcona-San Julián, Cristina</au><au>Alzina de Aguilar, Valentín</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hypothyroxinemia during pregnancy: the effect on neurodevelopment in the child</atitle><jtitle>International journal of developmental neuroscience</jtitle><addtitle>Int J Dev Neurosci</addtitle><date>2012-10</date><risdate>2012</risdate><volume>30</volume><issue>6</issue><spage>435</spage><epage>438</epage><pages>435-438</pages><issn>0736-5748</issn><eissn>1873-474X</eissn><abstract>► A lack of iodine in the diet may result in the mother becoming iodine deficient, and subsequently hypothyroxinaemic. ► Maternal hypothyroxinemia has a detrimental effect on fetal brain development. ► Screening fT4 at 12 weeks could indicate a subgroup of women whose infants would benefit from an increase of maternal fT4.
Experimental studies have shown that maternal hypothyroxinemia during early pregnancy is associated with poor neurodevelopment in affected offspring.
The aim of this study was to assess the impact of maternal serum free T4 on psychomotor development of offspring.
The study involved 147 women in the third trimester (week 37) of pregnancy. TSH and free T4 serum levels were measured at 37 week gestation. The children were evaluated between 38 and 60 months of age by the McCarthy Scales of Children's Abilities.
54.4% of the women had a free T4 below the threshold of hypothyroxinemia. We find a significant effect of maternal hypothyroxinemia on the general cognitive index, and on perceptual-manipulative and memory coefficients.</abstract><cop>United States</cop><pub>Elsevier Ltd</pub><pmid>22877976</pmid><doi>10.1016/j.ijdevneu.2012.07.004</doi><tpages>4</tpages></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Child, Preschool Cognition Disorders - etiology Developmental Disabilities - complications Developmental Disabilities - etiology Female Humans Hypothyroidism - physiopathology Hypothyroidism - urine Hypothyroxinemia Indexing in process Iodine - urine Iodine intake Male Neurodevelopment Pregnancy Pregnancy Trimester, First Prenatal Exposure Delayed Effects - physiopathology Prenatal Exposure Delayed Effects - urine Psychomotor Performance - physiology Retrospective Studies Thyroid Gland - physiopathology |
| title | Hypothyroxinemia during pregnancy: the effect on neurodevelopment in the child |
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