Altered neurochemical profile in the McGill-R-Thy1-APP rat model of Alzheimer's disease: a longitudinal in vivo 1H MRS study

We investigated metabolite levels during the progression of pathology in McGill‐R‐Thy1‐APP rats, a transgenic animal model of Alzheimer's disease, and in healthy age‐matched controls. Rats were subjected to in vivo 1H magnetic resonance spectroscopy (MRS) of the dorsal hippocampus at age 3, 9 a...

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Veröffentlicht in:	Journal of neurochemistry 2012-11, Vol.123 (4), p.532-541
Hauptverfasser:	Nilsen, Linn H., Melø, Torun M., Sæther, Oddbjørn, Witter, Menno P., Sonnewald, Ursula
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult and adolescent clinical studies Alzheimer's disease Biological and medical sciences biomarkers Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases GABA glutamate Indexing in process Medical sciences metabolism Metabolites N-acetylaspartate Neurochemistry Neurology Organic mental disorders. Neuropsychology Pathology Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry transgenic rats
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