Effects of aripiprazole and clozapine on the treatment of glycolytic carbon in PC12 cells

Aripiprazole is the only atypical antipsychotic drug known to cause the phosphorylation of AMP-activated protein kinase (AMPK) in PC12 cells. However, the molecular mechanisms underlying this phosphorylation in aripiprazole-treated PC12 cells have not yet been clarified. Here, using PC12 cells, we s...

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Veröffentlicht in:	Journal of Neural Transmission 2012-11, Vol.119 (11), p.1327-1342
Hauptverfasser:	Ota, Akira, Nakashima, Akira, Kaneko, Yoko S., Mori, Keiji, Nagasaki, Hiroshi, Takayanagi, Takeshi, Itoh, Mitsuyasu, Kondo, Kazunao, Nagatsu, Toshiharu, Ota, Miyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Diphosphate - metabolism Adenosine Triphosphate - metabolism Animals Antipsychotic Agents - pharmacology Apoptosis - drug effects Aripiprazole Basic Neurosciences Carbon - metabolism Cell Survival - drug effects Clozapine - pharmacology Dihydrolipoamide Dehydrogenase - genetics Dihydrolipoamide Dehydrogenase - metabolism Dose-Response Relationship, Drug Electron Transport Complex IV - metabolism Extracellular Fluid - drug effects Gene Expression Regulation, Enzymologic - drug effects Genetics and Immunology - Original Article Glucose - pharmacology Glycolysis - drug effects Hypoxanthine Phosphoribosyltransferase - genetics Hypoxanthine Phosphoribosyltransferase - metabolism Indexing in process Isocitrate Dehydrogenase - genetics Isocitrate Dehydrogenase - metabolism Ketone Oxidoreductases - genetics Ketone Oxidoreductases - metabolism Lactic Acid - metabolism Medicine Medicine & Public Health Membrane Potential, Mitochondrial - drug effects NAD - metabolism Neurology Neurosciences Oxidoreductases - genetics Oxidoreductases - metabolism PC12 Cells - drug effects PC12 Cells - enzymology Piperazines - pharmacology Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Psychiatry Pyruvic Acid - metabolism Quinolones - pharmacology Rats RNA, Messenger - metabolism Time Factors
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