Genetic variation in metabolic phenotypes: study designs and applications

Key Points Technical advances in mass spectrometry and NMR spectroscopy enable genome-wide screens to be carried out for the association between genetic variants and hundreds of metabolic traits in a single experiment. Metabolite concentrations are direct readouts of biological processes and can pla...

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Veröffentlicht in:	Nature reviews. Genetics 2012-11, Vol.13 (11), p.759-769
Hauptverfasser:	Suhre, Karsten, Gieger, Christian
Format:	Artikel
Sprache:	eng
Schlagworte:	631/1647/320 631/208/205/2138 631/208/457/649 Agriculture Amino acids Animal Genetics and Genomics Biological and medical sciences Biomedical and Life Sciences Biomedical Research - methods Biomedical Research - trends Biomedicine Cancer Research Chromatography Disease Environmental health Epidemiology Fundamental and applied biological sciences. Psychology Gene Function Gene loci Genetic Variation Genetics Genetics of eukaryotes. Biological and molecular evolution Genome-Wide Association Study - methods Genomes Genotype Human Genetics Humans Lifestyles Lipids Mass spectrometry Metabolism Metabolites Metabolomics - methods Nuclear magnetic resonance spectroscopy Phenotype Physiological aspects Plasma Research Design review-article Scientific imaging Urine
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