Antiepileptic drugs and suicidality
The current study is a systematic review of the literature concerning the possible relationship of antiepileptics and suicide-related clinical features and behaviours. A MEDLINE search returned 863 papers but only five were chosen as relevant. A critical analysis of the Food and Drug Administration...
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| Veröffentlicht in: | Journal of psychopharmacology (Oxford) 2012-11, Vol.26 (11), p.1401-1407 |
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| container_issue | 11 |
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| container_title | Journal of psychopharmacology (Oxford) |
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| creator | Fountoulakis, Konstantinos N Gonda, Xenia Samara, Myrto Siapera, Marianna Karavelas, Vaggelis Ristic, Dragana I Iacovides, Apostolos |
| description | The current study is a systematic review of the literature concerning the possible relationship of antiepileptics and suicide-related clinical features and behaviours. A MEDLINE search returned 863 papers but only five were chosen as relevant. A critical analysis of the Food and Drug Administration report is also included. Overall, the current review suggests there are no convincing data concerning a ‘class effect’ of antiepileptics in inducing any type of suicide-related behaviours. Further research is needed concerning topiramate, lamotrigine and maybe leviracetam. Clinicians are expected to inform patients and their families on the possible increased risk but it is important not to overemphasise the issue, since stopping or refusing to start antiepileptics may result in serious harm, including death of the patient. Future randomised controlled trials should specifically focus on issues concerning depression and suicidal thoughts in patients with epilepsy. |
| doi_str_mv | 10.1177/0269881112440514 |
| format | Article |
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Future randomised controlled trials should specifically focus on issues concerning depression and suicidal thoughts in patients with epilepsy.</description><subject>Anticonvulsants - adverse effects</subject><subject>Clinical trials</subject><subject>Depression - epidemiology</subject><subject>Drugs</subject><subject>Epilepsy</subject><subject>Humans</subject><subject>Indexing in process</subject><subject>Psychopharmacology</subject><subject>Risk</subject><subject>Suicidal Ideation</subject><subject>Suicide - statistics & numerical data</subject><subject>Suicide, Attempted - statistics & numerical data</subject><subject>Suicides & suicide attempts</subject><subject>Systematic review</subject><subject>United States</subject><subject>United States Food and Drug Administration</subject><issn>0269-8811</issn><issn>1461-7285</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkM1Lw0AQxRdRbKzePUmhFy_RndnPHEvxCwpe9Bw2m03ZkiYxmxz635vYKlIQPAxzmN97w3uEXAO9A1DqnqJMtAYA5JwK4CckAi4hVqjFKYnGczzeJ-QihA2lILkU52SCyOkwGJH5ouq8a3zpms7bWd726zAzVT4Lvbc-N6XvdpfkrDBlcFeHPSXvjw9vy-d49fr0slysYsuRdTG3tsgBnWYOnc0SKawQAExIaVTuqFGSSiWRobKojc4yq5lkjDosssIkbEpu975NW3_0LnTp1gfrytJUru5DOsQUyDgH-Q8UkLFESz2g8yN0U_dtNQT5oihnXI8U3VO2rUNoXZE2rd-adpcCTceu0-OuB8nNwbjPti7_EXyXOwDxHghm7X59_cvwE3ingpw</recordid><startdate>20121101</startdate><enddate>20121101</enddate><creator>Fountoulakis, Konstantinos N</creator><creator>Gonda, Xenia</creator><creator>Samara, Myrto</creator><creator>Siapera, Marianna</creator><creator>Karavelas, Vaggelis</creator><creator>Ristic, Dragana I</creator><creator>Iacovides, Apostolos</creator><general>SAGE Publications</general><general>Sage Publications Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>20121101</creationdate><title>Antiepileptic drugs and suicidality</title><author>Fountoulakis, Konstantinos N ; Gonda, Xenia ; Samara, Myrto ; Siapera, Marianna ; Karavelas, Vaggelis ; Ristic, Dragana I ; Iacovides, Apostolos</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c423t-4ccfd12e83e2ecb965c55113566a7de0a7606762327c28a8bbc836330e2fbfa93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Anticonvulsants - adverse effects</topic><topic>Clinical trials</topic><topic>Depression - epidemiology</topic><topic>Drugs</topic><topic>Epilepsy</topic><topic>Humans</topic><topic>Indexing in process</topic><topic>Psychopharmacology</topic><topic>Risk</topic><topic>Suicidal Ideation</topic><topic>Suicide - statistics & numerical data</topic><topic>Suicide, Attempted - statistics & numerical data</topic><topic>Suicides & suicide attempts</topic><topic>Systematic review</topic><topic>United States</topic><topic>United States Food and Drug Administration</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fountoulakis, Konstantinos N</creatorcontrib><creatorcontrib>Gonda, Xenia</creatorcontrib><creatorcontrib>Samara, Myrto</creatorcontrib><creatorcontrib>Siapera, Marianna</creatorcontrib><creatorcontrib>Karavelas, Vaggelis</creatorcontrib><creatorcontrib>Ristic, Dragana I</creatorcontrib><creatorcontrib>Iacovides, Apostolos</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Journal of psychopharmacology (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fountoulakis, Konstantinos N</au><au>Gonda, Xenia</au><au>Samara, Myrto</au><au>Siapera, Marianna</au><au>Karavelas, Vaggelis</au><au>Ristic, Dragana I</au><au>Iacovides, Apostolos</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antiepileptic drugs and suicidality</atitle><jtitle>Journal of psychopharmacology (Oxford)</jtitle><addtitle>J Psychopharmacol</addtitle><date>2012-11-01</date><risdate>2012</risdate><volume>26</volume><issue>11</issue><spage>1401</spage><epage>1407</epage><pages>1401-1407</pages><issn>0269-8811</issn><eissn>1461-7285</eissn><coden>JOPSEQ</coden><abstract>The current study is a systematic review of the literature concerning the possible relationship of antiepileptics and suicide-related clinical features and behaviours. 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| fulltext | fulltext |
| identifier | ISSN: 0269-8811 |
| ispartof | Journal of psychopharmacology (Oxford), 2012-11, Vol.26 (11), p.1401-1407 |
| issn | 0269-8811 1461-7285 |
| language | eng |
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| source | MEDLINE; SAGE Complete |
| subjects | Anticonvulsants - adverse effects Clinical trials Depression - epidemiology Drugs Epilepsy Humans Indexing in process Psychopharmacology Risk Suicidal Ideation Suicide - statistics & numerical data Suicide, Attempted - statistics & numerical data Suicides & suicide attempts Systematic review United States United States Food and Drug Administration |
| title | Antiepileptic drugs and suicidality |
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