Sex and dose-related differences in methylphenidate adolescent locomotor sensitization and effects on brain-derived neurotrophic factor

This study analyzed repeated methylphenidate (MPH) administration and its effects on brain-derived neurotrophic factor (BDNF) in the dorsal striatum and nucleus accumbens of male and female adolescent rats. In Experiment 1, rats were administered intraperitoneal (ip) saline, 1, 3, or 5 mg/kg dose of...

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Veröffentlicht in:	Journal of psychopharmacology (Oxford) 2012-11, Vol.26 (11), p.1480-1488
Hauptverfasser:	Brown, Russell W, Hughes, Benjamin A, Hughes, Andrew B, Sheppard, A Brianna, Perna, Marla K, Ragsdale, W Lee, Roeding, Ross L, Pond, Brooks B
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Behavior, Animal - drug effects Biological and medical sciences Brain-Derived Neurotrophic Factor - metabolism Corpus Striatum - drug effects Corpus Striatum - metabolism Dopamine Uptake Inhibitors - administration & dosage Dopamine Uptake Inhibitors - pharmacology Dose-Response Relationship, Drug Drug dosages Female Gender differences Indexing in process Male Medical sciences Methylphenidate - administration & dosage Methylphenidate - pharmacology Motor ability Motor Activity - drug effects Neuropharmacology Nucleus Accumbens - drug effects Nucleus Accumbens - metabolism Pharmacology. Drug treatments Proteins Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Psychotropic drugs Rats Rats, Sprague-Dawley Sex Factors Side effects Teenagers
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