Novel sulfanylphthalimide analogues as highly potent inhibitors of monoamine oxidase B

Monoamine oxidase (MAO) plays an essential role in the catabolism of neurotransmitter amines. The two isoforms of this enzyme, MAO-A and -B, are considered to be drug targets for the therapy of depression and neurodegenerative diseases, respectively. Based on a recent report that the phthalimide moi...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2012-11, Vol.22 (21), p.6632-6635
Hauptverfasser:	Van der Walt, Mietha M., Terre’Blanche, Gisella, Petzer, Anél, Petzer, Jacobus P.
Format:	Artikel
Sprache:	eng
Schlagworte:	amine oxidase (flavin-containing) amines Biological and medical sciences chemistry drugs Enzyme Activation - drug effects Humans Indexing in process Inhibition Inhibitory Concentration 50 Isatin MAO Medical sciences metabolism Monoamine oxidase Monoamine Oxidase - metabolism Monoamine Oxidase Inhibitors - chemical synthesis Monoamine Oxidase Inhibitors - chemistry Monoamine Oxidase Inhibitors - pharmacology neurodegenerative diseases Pharmacology. Drug treatments Phthalimide Phthalimides - chemical synthesis Phthalimides - chemistry Phthalimides - pharmacology Protein Isoforms Sulfanylphthalimide therapeutics
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!