Imipenem Resistance in Klebsiella pneumoniae Is Associated to the Combination of Plasmid-Mediated CMY-4 AmpC β-Lactamase and Loss of an Outer Membrane Protein

This study was conducted to identify the molecular mechanisms of imipenem resistance in a Klebsiella pneumoniae (Kp16137) isolate recovered in August 2008 at the University Hospital Sahloul, Sousse, Tunisia. The strain was identified with the API 20E system; antibiotic-containing disks were used for...

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Veröffentlicht in:	Microbial drug resistance (Larchmont, N.Y.) N.Y.), 2012-10, Vol.18 (5), p.479-483
Hauptverfasser:	Dahmen, Safia, Mansour, Wejdène, Charfi, Karama, Boujaafar, Noureddine, Arlet, Guillaume, Bouallègue, Olfa
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - pharmacology Antibiotics Bacterial Outer Membrane Proteins - genetics Bacterial Outer Membrane Proteins - metabolism Bacterial Proteins - genetics beta -Lactam antibiotics beta -Lactamase beta-Lactam Resistance - genetics beta-Lactamases - genetics Carbapenems Cephalosporins Diffusion Drug resistance Female Hospitals Humans Imipenem Imipenem - pharmacology Klebsiella pneumoniae Klebsiella pneumoniae - drug effects Klebsiella pneumoniae - genetics Klebsiella pneumoniae - isolation & purification Mechanisms Microbial Sensitivity Tests Middle Aged Molecular modelling Nylon outer membrane proteins Permeability Plasmids Plasmids - genetics Polymerase Chain Reaction Porins Primers Probes Tunisia - epidemiology
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