Combined Fiber Modifications Both to Target alpha sub(v) beta sub(6) and Detarget the Coxsackievirus-Adenovirus Receptor Improve Virus Toxicity Profiles In Vivo but Fail to Improve Antitumoral Efficacy Relative to Adenovirus Serotype 5

Achieving high-efficiency tumor targeting after systemic delivery is a considerable challenge facing oncolytic gene therapists. Efficient retargeting should be combined with efforts to improve in vivo safety, reduce hepa-totoxicity, minimize off-target interactions, and improve antitumoral potency a...

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