role of probiotics and natural bioactive compounds in modulation of the common molecular pathways in pathogenesis of atherosclerosis and cancer
Atherosclerosis and cancer are ranked among the most serious health problems in human medicine. Various predictive and etiological factors, biomarkers and molecular pathways of disease development and progression common to atherosclerosis and cancer suggest that the two most common diseases in world...
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| Veröffentlicht in: | Biológia 2012-02, Vol.67 (1), p.1-13 |
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| creator | Bomba, Alojz Brandeburová, Andrea Ričanyová, Júlia Strojný, Ladislav Chmelárová, Anna Szabadosová, Viktória Pramuková, Beáta Žofčáková, Jana Salaj, Rastislav Supuková, Anna Čokášová, Denisa |
| description | Atherosclerosis and cancer are ranked among the most serious health problems in human medicine. Various predictive and etiological factors, biomarkers and molecular pathways of disease development and progression common to atherosclerosis and cancer suggest that the two most common diseases in worldwide dimension are far more closely aligned than previously believed. It is hypothesized that atherosclerosis and cancer are variants of a similar disease process. Shared disease progression in atherosclerosis and cancer is the emergence of similar novel approaches to therapy. On previous knowledge, it may be hypothesized that not only common approaches to therapy but also preventive strategies could be efficacious in both diseases. The results of in vitro and in vivo animal experiments, clinical and epidemiological studies and also the results of our experiments using animal experimental models of atherosclerosis and carcinogenesis indicate that probiotics, prebiotics, plants and their extracts and poly-unsaturated fatty acids could be effectively used in prevention of both atherosclerosis and colorectal cancer and decrease the disease risk. Future research should answer the question whether probiotic microorganisms and natural bioactive substances could effectively influence the molecular mechanisms in pathogenesis of atherosclerosis and cancer. |
| doi_str_mv | 10.2478/s11756-011-0155-6 |
| format | Article |
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Various predictive and etiological factors, biomarkers and molecular pathways of disease development and progression common to atherosclerosis and cancer suggest that the two most common diseases in worldwide dimension are far more closely aligned than previously believed. It is hypothesized that atherosclerosis and cancer are variants of a similar disease process. Shared disease progression in atherosclerosis and cancer is the emergence of similar novel approaches to therapy. On previous knowledge, it may be hypothesized that not only common approaches to therapy but also preventive strategies could be efficacious in both diseases. The results of in vitro and in vivo animal experiments, clinical and epidemiological studies and also the results of our experiments using animal experimental models of atherosclerosis and carcinogenesis indicate that probiotics, prebiotics, plants and their extracts and poly-unsaturated fatty acids could be effectively used in prevention of both atherosclerosis and colorectal cancer and decrease the disease risk. 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Future research should answer the question whether probiotic microorganisms and natural bioactive substances could effectively influence the molecular mechanisms in pathogenesis of atherosclerosis and cancer.</description><subject>animal experimentation</subject><subject>Animal models</subject><subject>Arteriosclerosis</subject><subject>atherosclerosis</subject><subject>bioactive properties</subject><subject>biomarkers</subject><subject>Biomedical and Life Sciences</subject><subject>cancer</subject><subject>Carcinogenesis</subject><subject>Cell Biology</subject><subject>Colorectal cancer</subject><subject>colorectal neoplasms</subject><subject>disease course</subject><subject>epidemiological studies</subject><subject>Fatty acids</subject><subject>Life Sciences</subject><subject>medicine</subject><subject>Microbiology</subject><subject>Microorganisms</subject><subject>Molecular modelling</subject><subject>natural bioactive compounds</subject><subject>Plant diseases</subject><subject>plant extracts</subject><subject>Plant Sciences</subject><subject>prebiotics</subject><subject>probiotics</subject><subject>Review</subject><subject>risk</subject><subject>therapeutics</subject><subject>Zoology</subject><issn>0006-3088</issn><issn>1336-9563</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNqNkMGOFCEQhonRxHH0ATzZRy-tFNDAHDyYjasmm3jQPZMamp5lQ8MItJt5Cl9ZeturiQegoP6vivoJeQ30HRNKvy8AapA9BWhrGHr5hOyAc9kfBsmfkh2lVPacav2cvCjlnlKhBgo78jun4Lo0deecjj5Vb0uHcewi1iVj6Nob2up_uc6m-ZyWOJbOx25O4xKw-hRXtt49pue0JoKzLZW7M9a7B7w8ytc4nVx0xZcVaFeXU7Fh3f3W0WK0Lr8kzyYMxb36e-7J7fWnH1df-ptvn79efbzprRCs9oJzNU6HwVGl8AgKFKIENypJkXHN7IAcAfBotbZCTVxbOI5uEKNkKOSB78nbrW6b--fiSjWzL9aFgNGlpRgANjCmdfNwT2CT2vbZkt1kztnPmC8GqFnNN5v5pplvVvONbMyHjXnAUF0e3SkvlxaY-7Tk2Ab7NysVQOPZxpfWK57-C2zQmw2aMBk8ZV_M7XdGQdAmODBN-R-SUqer</recordid><startdate>20120201</startdate><enddate>20120201</enddate><creator>Bomba, Alojz</creator><creator>Brandeburová, Andrea</creator><creator>Ričanyová, Júlia</creator><creator>Strojný, Ladislav</creator><creator>Chmelárová, Anna</creator><creator>Szabadosová, Viktória</creator><creator>Pramuková, Beáta</creator><creator>Žofčáková, Jana</creator><creator>Salaj, Rastislav</creator><creator>Supuková, Anna</creator><creator>Čokášová, Denisa</creator><general>Springer-Verlag</general><general>SP Versita</general><general>Versita</general><scope>FBQ</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20120201</creationdate><title>role of probiotics and natural bioactive compounds in modulation of the common molecular pathways in pathogenesis of atherosclerosis and cancer</title><author>Bomba, Alojz ; 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| source | SpringerLink Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | animal experimentation Animal models Arteriosclerosis atherosclerosis bioactive properties biomarkers Biomedical and Life Sciences cancer Carcinogenesis Cell Biology Colorectal cancer colorectal neoplasms disease course epidemiological studies Fatty acids Life Sciences medicine Microbiology Microorganisms Molecular modelling natural bioactive compounds Plant diseases plant extracts Plant Sciences prebiotics probiotics Review risk therapeutics Zoology |
| title | role of probiotics and natural bioactive compounds in modulation of the common molecular pathways in pathogenesis of atherosclerosis and cancer |
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