Quantitative changes of nicotinic receptors in the hippocampus of dystrophin-deficient mice

Abstract Lack of dystrophin in Duchenne muscle dystrophy (DMD) and in the mutant mdx mouse results in progressive muscle degeneration, structural changes at the neuromuscular junction, and destabilization of the nicotinic acetylcholine receptors (nAChRs). One-third of DMD patients also present non-p...

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Veröffentlicht in:	Brain research 2012-11, Vol.1483, p.96-104
Hauptverfasser:	Ghedini, Paulo César, Avellar, Maria Christina W, De Lima, Thereza Christina M, Lima-Landman, Maria Teresa R, Lapa, Antônio José, Souccar, Caden
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Alkaloids - pharmacokinetics Analysis of Variance animal models Animals Azocines - pharmacokinetics binding sites Biological and medical sciences Bungarotoxins - metabolism Bungarotoxins - pharmacokinetics central nervous system diseases cerebellum cholinergic receptors cognition cortex Diseases of striated muscles. Neuromuscular diseases Dose-Response Relationship, Drug Duchenne muscle dystrophy Dystrophin Dystrophin - deficiency Dystrophin - genetics Hippocampus Hippocampus - drug effects Hippocampus - metabolism Indexing in process Isotopes - pharmacokinetics Male mdx mouse Medical sciences Memory Mice Mice, Inbred C57BL Mice, Inbred mdx muscles mutants Neurology Nicotinic acetylcholine receptor Nicotinic Antagonists - pharmacokinetics patients Protein Binding - drug effects Protein Binding - genetics Quinolizines - pharmacokinetics Receptors, Nicotinic - genetics Receptors, Nicotinic - metabolism reverse transcriptase polymerase chain reaction RNA, Messenger - metabolism
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