Effect of cycloheximide on epidermal growth factor receptor trafficking and signaling

► Cycloheximide induces internalization and redistribution of EGF receptor. ► Cycloheximide affects EGF-induced activation of EGF receptor and ERK1/2. ► MAPK p38 is involved in the cycloheximide-induced internalization of EGF receptor. Cycloheximide is the most common protein synthesis inhibitor, an...

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Veröffentlicht in:	FEBS letters 2012-10, Vol.586 (20), p.3575-3581
Hauptverfasser:	Oksvold, Morten P., Pedersen, Nina Marie, Forfang, Lise, Smeland, Erlend B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cycloheximide Cycloheximide - pharmacology EGF receptor Enzyme Activation - drug effects HeLa Cells Humans Mice Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - metabolism p38 MAPK p38 Mitogen-Activated Protein Kinases - metabolism Protein Transport - drug effects Receptor, Epidermal Growth Factor - metabolism Signal Transduction - drug effects Signaling Stress
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