Immunotherapy using IL-2 and GM-CSF is a potential treatment for multidrug-resistant Mycobacterium tuberculosis

This study investigated the therapeutic effects of interleukin （IL）-2 and granulocyte-macrophage colony-stimulating factor （GM-CSF） co-administrated with antibacterial agents isoniazid （INH） and rifampin （RIF） to treat a mouse model of tuberculo- sis （TB） infection. A drug-susceptible TB strain, H37...

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Veröffentlicht in:	Science China. Life sciences 2012-09, Vol.55 (9), p.800-806
Hauptverfasser:	Zhang, YongRong, Liu, Jian, Wang, Yong, Xian, QiaoYang, Shao, LingYun, Yang, Zhong, Wang, XiaoNing
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Antibacterial agents Antibiotics, Antitubercular - therapeutic use Biomedical and Life Sciences Colony-forming cells Cytokines Drug resistance Drug Therapy, Combination GM-CSF Granulocyte-macrophage colony-stimulating factor Granulocyte-Macrophage Colony-Stimulating Factor - therapeutic use IL-2 Immunotherapy Immunotherapy - methods Infection Interleukin 2 Interleukin-2 - therapeutic use Isoniazid Isoniazid - therapeutic use Life Sciences Lung Mice Mice, Inbred C57BL Multidrug resistance Mycobacterium Mycobacterium tuberculosis Mycobacterium tuberculosis - drug effects Research Paper Rifampin Rifampin - therapeutic use Spleen Survival Survival Rate Treatment Outcome Tuberculosis Tuberculosis, Multidrug-Resistant - mortality Tuberculosis, Multidrug-Resistant - therapy 免疫治疗小鼠模型巨噬细胞集落刺激因子抗菌药物治疗效果结核分枝杆菌
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