Influenza enhances caspase-1 in bronchial epithelial cells from asthmatic volunteers and is associated with pathogenesis

Background The leading cause of asthma exacerbation is respiratory viral infection. Innate antiviral defense pathways are altered in the asthmatic epithelium, yet involvement of inflammasome signaling in virus-induced asthma exacerbation is not known. Objective This study compared influenza-induced...

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Veröffentlicht in:	Journal of allergy and clinical immunology 2012-10, Vol.130 (4), p.958-967.e14
Hauptverfasser:	Bauer, Rebecca N., BA, Brighton, Luisa E., BS, Mueller, Loretta, PhD, Xiang, Zhidan, PhD, Rager, Julia E., MS, Fry, Rebecca C., PhD, Peden, David B., MD, MS, Jaspers, Ilona, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals antiviral Apoptosis Regulatory Proteins Asthma Asthma - etiology Asthma - immunology Biological and medical sciences Bronchi - immunology CARD Signaling Adaptor Proteins Caspase 1 - analysis Caspase 1 - physiology Caspase-1 Cells, Cultured Cytokines Cytoskeletal Proteins - analysis Epithelial cell Epithelial cells Epithelial Cells - immunology Epithelium Female Fundamental and applied biological sciences. Psychology Fundamental immunology Gene expression Human viral diseases Humans Immune system Immunity, Innate Immunofluorescence Immunopathology Infection Infectious diseases inflammasome influenza Influenza A virus Influenza, Human - complications innate immunity Interleukin 6 Interleukin-1beta - biosynthesis Medical sciences Mice Mice, Inbred C57BL Microscopy Polymerase chain reaction Replication Respiratory tract Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Signal transduction Viral diseases Viral diseases of the respiratory system and ent viral diseases Viral infections Virus Replication
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