Inflammasome activation in bovine monocytes by extracellular ATP does not require the purinergic receptor P2X7

Extracellular adenosine triphosphate (ATP) is a second signal for the assembly of the NLR family, pyrin domain-containing 3 (NLRP3) inflammasome, which form a framework to activate caspase 1, leading to the processing and secretion of the pro-inflammatory cytokine interleukin-1β (IL-1β). The aim of...

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Veröffentlicht in:	Developmental and comparative immunology 2012-10, Vol.38 (2), p.312-320
Hauptverfasser:	Hussen, Jamal, Düvel, Anna, Koy, Mirja, Schuberth, Hans-Joachim
Format:	Artikel
Sprache:	eng
Schlagworte:	adenosine triphosphate Adenosine Triphosphate - metabolism agonists Animals antagonists ATP calcium Calcium influx Caspase-1 Cattle Cattle - immunology CD4 antigen CD8 antigen Cell activation Channel pores Data processing Humans Inflammasome Inflammasomes - immunology Inflammation interleukin-1beta Interleukin-1beta - immunology Interleukin-1beta - secretion Ion channels Lipopolysaccharides Lipopolysaccharides - metabolism Lymphocytes T Monocyte Monocytes Monocytes - immunology Monocytes - metabolism Oxygen Potassium Purine P2X receptors Purine receptors Purinergic P2X Receptor Antagonists - pharmacology Pyrin protein Reactive oxygen species Reactive Oxygen Species - metabolism Receptors, Purinergic P2X7 - metabolism secretion T-lymphocytes T-Lymphocytes - immunology
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