Subthalamic local field potentials after seven-year deep brain stimulation in Parkinson's disease
Studies describing subthalamic (STN) local field potentials (LFPs) recorded during deep brain stimulation (DBS) in patients with Parkinson's disease (PD), within the first month after DBS electrode implant, show that DBS modulates specific STN oscillations: whereas low-frequency (LF) oscillatio...
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| Veröffentlicht in: | Experimental neurology 2012-10, Vol.237 (2), p.312-317 |
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| creator | Giannicola, Gaia Rosa, Manuela Servello, Domenico Menghetti, Claudia Carrabba, Giorgio Pacchetti, Claudio Zangaglia, Roberta Cogiamanian, Filippo Scelzo, Emma Marceglia, Sara Rossi, Lorenzo Priori, Alberto |
| description | Studies describing subthalamic (STN) local field potentials (LFPs) recorded during deep brain stimulation (DBS) in patients with Parkinson's disease (PD), within the first month after DBS electrode implant, show that DBS modulates specific STN oscillations: whereas low-frequency (LF) oscillations (2–7Hz) increase, beta oscillations (8–30Hz) variably decrease. No data show whether LFPs remain stable for longer than one month after DBS surgery. Having long-term information is essential especially for use as a long-term feedback control signal for adaptive DBS systems. To evaluate how STN activity behaves years after prolonged chronic stimulation in PD we studied STN LFPs at rest without DBS and during ongoing DBS, in 11 parkinsonian patients 7years (7.54±1.04) after STN electrode implantation for DBS (hyperchronic group) and in 16 patients 3days after STN electrode implantation (acute group). STN LF and beta-band LFPs recorded at rest at 7years contained almost the same information as those recorded at 3days. STN recordings showed similar LFP responses to DBS in the acute and hyperchronic stages: whereas during ongoing DBS the LF power band increased for the whole population, beta activity decreased only in nuclei with significant beta activity at baseline. The LF/beta power ratio in all nuclei changed in both study groups, suggesting that this variable might be an even more informative marker of PD than the single LF and beta bands. Because STN LFP activity patterns and STN LFP responses to DBS stay almost unchanged for years after DBS electrode implantation they should provide a consistent feedback control signal for adaptive DBS.
►We studied whether STN activity in PD patients remain stable after DBS for years. ►STN activity patterns remain almost unchanged after DBS for 7years. ►DBS-induced power changes persist years after implant and chronic stimulation. ►Adaptive DBS strategies based on STN activity can remain unchanged for years. |
| doi_str_mv | 10.1016/j.expneurol.2012.06.012 |
| format | Article |
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►We studied whether STN activity in PD patients remain stable after DBS for years. ►STN activity patterns remain almost unchanged after DBS for 7years. ►DBS-induced power changes persist years after implant and chronic stimulation. ►Adaptive DBS strategies based on STN activity can remain unchanged for years.</description><identifier>ISSN: 0014-4886</identifier><identifier>EISSN: 1090-2430</identifier><identifier>DOI: 10.1016/j.expneurol.2012.06.012</identifier><identifier>PMID: 22735488</identifier><identifier>CODEN: EXNEAC</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Action Potentials - physiology ; Adaptive ; Adult ; Aged ; Beta activity ; Biological and medical sciences ; Chronic stimulation ; Deep Brain Stimulation ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Female ; Follow-Up Studies ; Humans ; Indexing in process ; Local field potentials ; Low frequency activity ; Male ; Medical sciences ; Middle Aged ; Neurology ; Parkinson Disease - physiopathology ; Parkinson Disease - therapy ; Parkinson's disease ; Subthalamic nucleus ; Subthalamus - physiopathology</subject><ispartof>Experimental neurology, 2012-10, Vol.237 (2), p.312-317</ispartof><rights>2012 Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2012 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c434t-4a7813ce6a54362ca9e0472334ff72d857ead31c43454319cf9ea5bd304702223</citedby><cites>FETCH-LOGICAL-c434t-4a7813ce6a54362ca9e0472334ff72d857ead31c43454319cf9ea5bd304702223</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.expneurol.2012.06.012$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26415170$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22735488$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Giannicola, Gaia</creatorcontrib><creatorcontrib>Rosa, Manuela</creatorcontrib><creatorcontrib>Servello, Domenico</creatorcontrib><creatorcontrib>Menghetti, Claudia</creatorcontrib><creatorcontrib>Carrabba, Giorgio</creatorcontrib><creatorcontrib>Pacchetti, Claudio</creatorcontrib><creatorcontrib>Zangaglia, Roberta</creatorcontrib><creatorcontrib>Cogiamanian, Filippo</creatorcontrib><creatorcontrib>Scelzo, Emma</creatorcontrib><creatorcontrib>Marceglia, Sara</creatorcontrib><creatorcontrib>Rossi, Lorenzo</creatorcontrib><creatorcontrib>Priori, Alberto</creatorcontrib><title>Subthalamic local field potentials after seven-year deep brain stimulation in Parkinson's disease</title><title>Experimental neurology</title><addtitle>Exp Neurol</addtitle><description>Studies describing subthalamic (STN) local field potentials (LFPs) recorded during deep brain stimulation (DBS) in patients with Parkinson's disease (PD), within the first month after DBS electrode implant, show that DBS modulates specific STN oscillations: whereas low-frequency (LF) oscillations (2–7Hz) increase, beta oscillations (8–30Hz) variably decrease. No data show whether LFPs remain stable for longer than one month after DBS surgery. Having long-term information is essential especially for use as a long-term feedback control signal for adaptive DBS systems. To evaluate how STN activity behaves years after prolonged chronic stimulation in PD we studied STN LFPs at rest without DBS and during ongoing DBS, in 11 parkinsonian patients 7years (7.54±1.04) after STN electrode implantation for DBS (hyperchronic group) and in 16 patients 3days after STN electrode implantation (acute group). STN LF and beta-band LFPs recorded at rest at 7years contained almost the same information as those recorded at 3days. STN recordings showed similar LFP responses to DBS in the acute and hyperchronic stages: whereas during ongoing DBS the LF power band increased for the whole population, beta activity decreased only in nuclei with significant beta activity at baseline. The LF/beta power ratio in all nuclei changed in both study groups, suggesting that this variable might be an even more informative marker of PD than the single LF and beta bands. Because STN LFP activity patterns and STN LFP responses to DBS stay almost unchanged for years after DBS electrode implantation they should provide a consistent feedback control signal for adaptive DBS.
►We studied whether STN activity in PD patients remain stable after DBS for years. ►STN activity patterns remain almost unchanged after DBS for 7years. ►DBS-induced power changes persist years after implant and chronic stimulation. ►Adaptive DBS strategies based on STN activity can remain unchanged for years.</description><subject>Action Potentials - physiology</subject><subject>Adaptive</subject><subject>Adult</subject><subject>Aged</subject><subject>Beta activity</subject><subject>Biological and medical sciences</subject><subject>Chronic stimulation</subject><subject>Deep Brain Stimulation</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Indexing in process</subject><subject>Local field potentials</subject><subject>Low frequency activity</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neurology</subject><subject>Parkinson Disease - physiopathology</subject><subject>Parkinson Disease - therapy</subject><subject>Parkinson's disease</subject><subject>Subthalamic nucleus</subject><subject>Subthalamus - physiopathology</subject><issn>0014-4886</issn><issn>1090-2430</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtv1DAUhS0EotOBvwDeILpJ6mecLKuKl1SJSoW1dce5ER4SO9hJRf99PZqhLLs6urrffegcQt5zVnPGm8t9jX_ngGuKYy0YFzVr6iIvyIazjlVCSfaSbBjjqlJt25yR85z3jLFOCfOanAlhpC6NDYG7dbf8ghEm7-gYHYx08Dj2dI4LhsXDmCkMCyaa8R5D9YCQaI84010CH2he_LSOsPgYaClvIf32IcfwMdPeZ4SMb8iroWzBtyfdkp-fP_24_lrdfP_y7frqpnJKqqVSYFouHTaglWyEgw6ZMkJKNQxG9K02CL3kB7gAvHNDh6B3vSwUE0LILbk47p1T_LNiXuzks8NxhIBxzZZzoYVopNHPo0x2bat10S0xR9SlmHPCwc7JT5AeCmQPUdi9fYrCHqKwrLFFyuS705F1N2H_NPfP-wJ8OAGQi-9DguB8_s81imtuDi9cHTks7t17TDY7j8Fh7xO6xfbRP_vMIwcSq5g</recordid><startdate>20121001</startdate><enddate>20121001</enddate><creator>Giannicola, Gaia</creator><creator>Rosa, Manuela</creator><creator>Servello, Domenico</creator><creator>Menghetti, Claudia</creator><creator>Carrabba, Giorgio</creator><creator>Pacchetti, Claudio</creator><creator>Zangaglia, Roberta</creator><creator>Cogiamanian, Filippo</creator><creator>Scelzo, Emma</creator><creator>Marceglia, Sara</creator><creator>Rossi, Lorenzo</creator><creator>Priori, Alberto</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>20121001</creationdate><title>Subthalamic local field potentials after seven-year deep brain stimulation in Parkinson's disease</title><author>Giannicola, Gaia ; Rosa, Manuela ; Servello, Domenico ; Menghetti, Claudia ; Carrabba, Giorgio ; Pacchetti, Claudio ; Zangaglia, Roberta ; Cogiamanian, Filippo ; Scelzo, Emma ; Marceglia, Sara ; Rossi, Lorenzo ; Priori, Alberto</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c434t-4a7813ce6a54362ca9e0472334ff72d857ead31c43454319cf9ea5bd304702223</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Action Potentials - physiology</topic><topic>Adaptive</topic><topic>Adult</topic><topic>Aged</topic><topic>Beta activity</topic><topic>Biological and medical sciences</topic><topic>Chronic stimulation</topic><topic>Deep Brain Stimulation</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Indexing in process</topic><topic>Local field potentials</topic><topic>Low frequency activity</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neurology</topic><topic>Parkinson Disease - physiopathology</topic><topic>Parkinson Disease - therapy</topic><topic>Parkinson's disease</topic><topic>Subthalamic nucleus</topic><topic>Subthalamus - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Giannicola, Gaia</creatorcontrib><creatorcontrib>Rosa, Manuela</creatorcontrib><creatorcontrib>Servello, Domenico</creatorcontrib><creatorcontrib>Menghetti, Claudia</creatorcontrib><creatorcontrib>Carrabba, Giorgio</creatorcontrib><creatorcontrib>Pacchetti, Claudio</creatorcontrib><creatorcontrib>Zangaglia, Roberta</creatorcontrib><creatorcontrib>Cogiamanian, Filippo</creatorcontrib><creatorcontrib>Scelzo, Emma</creatorcontrib><creatorcontrib>Marceglia, Sara</creatorcontrib><creatorcontrib>Rossi, Lorenzo</creatorcontrib><creatorcontrib>Priori, Alberto</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>Experimental neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Giannicola, Gaia</au><au>Rosa, Manuela</au><au>Servello, Domenico</au><au>Menghetti, Claudia</au><au>Carrabba, Giorgio</au><au>Pacchetti, Claudio</au><au>Zangaglia, Roberta</au><au>Cogiamanian, Filippo</au><au>Scelzo, Emma</au><au>Marceglia, Sara</au><au>Rossi, Lorenzo</au><au>Priori, Alberto</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Subthalamic local field potentials after seven-year deep brain stimulation in Parkinson's disease</atitle><jtitle>Experimental neurology</jtitle><addtitle>Exp Neurol</addtitle><date>2012-10-01</date><risdate>2012</risdate><volume>237</volume><issue>2</issue><spage>312</spage><epage>317</epage><pages>312-317</pages><issn>0014-4886</issn><eissn>1090-2430</eissn><coden>EXNEAC</coden><abstract>Studies describing subthalamic (STN) local field potentials (LFPs) recorded during deep brain stimulation (DBS) in patients with Parkinson's disease (PD), within the first month after DBS electrode implant, show that DBS modulates specific STN oscillations: whereas low-frequency (LF) oscillations (2–7Hz) increase, beta oscillations (8–30Hz) variably decrease. No data show whether LFPs remain stable for longer than one month after DBS surgery. Having long-term information is essential especially for use as a long-term feedback control signal for adaptive DBS systems. To evaluate how STN activity behaves years after prolonged chronic stimulation in PD we studied STN LFPs at rest without DBS and during ongoing DBS, in 11 parkinsonian patients 7years (7.54±1.04) after STN electrode implantation for DBS (hyperchronic group) and in 16 patients 3days after STN electrode implantation (acute group). STN LF and beta-band LFPs recorded at rest at 7years contained almost the same information as those recorded at 3days. STN recordings showed similar LFP responses to DBS in the acute and hyperchronic stages: whereas during ongoing DBS the LF power band increased for the whole population, beta activity decreased only in nuclei with significant beta activity at baseline. The LF/beta power ratio in all nuclei changed in both study groups, suggesting that this variable might be an even more informative marker of PD than the single LF and beta bands. Because STN LFP activity patterns and STN LFP responses to DBS stay almost unchanged for years after DBS electrode implantation they should provide a consistent feedback control signal for adaptive DBS.
►We studied whether STN activity in PD patients remain stable after DBS for years. ►STN activity patterns remain almost unchanged after DBS for 7years. ►DBS-induced power changes persist years after implant and chronic stimulation. ►Adaptive DBS strategies based on STN activity can remain unchanged for years.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>22735488</pmid><doi>10.1016/j.expneurol.2012.06.012</doi><tpages>6</tpages></addata></record> |
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| subjects | Action Potentials - physiology Adaptive Adult Aged Beta activity Biological and medical sciences Chronic stimulation Deep Brain Stimulation Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Female Follow-Up Studies Humans Indexing in process Local field potentials Low frequency activity Male Medical sciences Middle Aged Neurology Parkinson Disease - physiopathology Parkinson Disease - therapy Parkinson's disease Subthalamic nucleus Subthalamus - physiopathology |
| title | Subthalamic local field potentials after seven-year deep brain stimulation in Parkinson's disease |
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