Back pain among long-term survivors of childhood leukemia
The objectives of this study are to determine the prevalence and relative risk (RR) of back pain and identify possible mechanisms of back pain among childhood acute lymphoblastic leukemia (ALL) survivors. Surveys were mailed to 5 + -year survivors of childhood ALL aged 13 to 25 years. Survivors'...
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| Veröffentlicht in: | Journal of pediatric hematology/oncology 2012-11, Vol.34 (8), p.624-629 |
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| container_title | Journal of pediatric hematology/oncology |
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| creator | Bowers, Daniel C Griffith, Terri Gargan, Lynn Cochran, Cindy J Kleiber, Beverly Foxwell, Aleksandra Farrow-Gillespie, Alan Orlino, Angela Germann, Julie N |
| description | The objectives of this study are to determine the prevalence and relative risk (RR) of back pain and identify possible mechanisms of back pain among childhood acute lymphoblastic leukemia (ALL) survivors.
Surveys were mailed to 5 + -year survivors of childhood ALL aged 13 to 25 years. Survivors' siblings were also invited to participate in the study. Prevalence of back pain and hip pain among ALL survivors was determined and compared with siblings. Sex, treatment with radiation therapy, obesity, and physical activity were examined for an association with back pain and hip pain.
Forty-four of 99 (44.4%) ALL survivors reported back pain compared with 11 of 52 (21.2%) their siblings (P = 0.007; RR: 2.01; 95% confidence interval = 1.15-3.56). In contrast, 10 of 99 (10.1%) ALL survivors reported experiencing hip pain compared with 1 of 52 (2.0%) siblings experiencing hip pain [P = 0.07; RR: 4.95 (0.65 to 37.57)]. Twenty-six of 43 female survivors reported back pain compared with 18 of 56 male survivors who reported back pain (P = 0.005). Obesity, physical activity, and treatment with radiation therapy were not associated with back pain or hip pain.
This is the first study demonstrating an increased frequency of back pain among survivors of childhood ALL. Future studies are needed to better define the causes of back pain among childhood ALL survivors. |
| doi_str_mv | 10.1097/MPH.0b013e31827080de |
| format | Article |
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Surveys were mailed to 5 + -year survivors of childhood ALL aged 13 to 25 years. Survivors' siblings were also invited to participate in the study. Prevalence of back pain and hip pain among ALL survivors was determined and compared with siblings. Sex, treatment with radiation therapy, obesity, and physical activity were examined for an association with back pain and hip pain.
Forty-four of 99 (44.4%) ALL survivors reported back pain compared with 11 of 52 (21.2%) their siblings (P = 0.007; RR: 2.01; 95% confidence interval = 1.15-3.56). In contrast, 10 of 99 (10.1%) ALL survivors reported experiencing hip pain compared with 1 of 52 (2.0%) siblings experiencing hip pain [P = 0.07; RR: 4.95 (0.65 to 37.57)]. Twenty-six of 43 female survivors reported back pain compared with 18 of 56 male survivors who reported back pain (P = 0.005). Obesity, physical activity, and treatment with radiation therapy were not associated with back pain or hip pain.
This is the first study demonstrating an increased frequency of back pain among survivors of childhood ALL. Future studies are needed to better define the causes of back pain among childhood ALL survivors.</description><identifier>ISSN: 1077-4114</identifier><identifier>EISSN: 1536-3678</identifier><identifier>DOI: 10.1097/MPH.0b013e31827080de</identifier><identifier>PMID: 23108003</identifier><language>eng</language><publisher>United States</publisher><subject>Adolescent ; Adult ; Arthralgia - epidemiology ; Back Injuries - epidemiology ; Back Pain - epidemiology ; Female ; Health Surveys ; Hip Joint ; Humans ; Male ; Motor Activity ; Obesity - epidemiology ; Precursor Cell Lymphoblastic Leukemia-Lymphoma - therapy ; Prevalence ; Radiotherapy ; Risk ; Siblings ; Spinal Puncture - adverse effects ; Survivors ; Young Adult</subject><ispartof>Journal of pediatric hematology/oncology, 2012-11, Vol.34 (8), p.624-629</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c332t-2e061fe1c798f010ef3962fc668e5531e6b7815c6fab7c3640c4d8d8876243083</citedby><cites>FETCH-LOGICAL-c332t-2e061fe1c798f010ef3962fc668e5531e6b7815c6fab7c3640c4d8d8876243083</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23108003$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bowers, Daniel C</creatorcontrib><creatorcontrib>Griffith, Terri</creatorcontrib><creatorcontrib>Gargan, Lynn</creatorcontrib><creatorcontrib>Cochran, Cindy J</creatorcontrib><creatorcontrib>Kleiber, Beverly</creatorcontrib><creatorcontrib>Foxwell, Aleksandra</creatorcontrib><creatorcontrib>Farrow-Gillespie, Alan</creatorcontrib><creatorcontrib>Orlino, Angela</creatorcontrib><creatorcontrib>Germann, Julie N</creatorcontrib><title>Back pain among long-term survivors of childhood leukemia</title><title>Journal of pediatric hematology/oncology</title><addtitle>J Pediatr Hematol Oncol</addtitle><description>The objectives of this study are to determine the prevalence and relative risk (RR) of back pain and identify possible mechanisms of back pain among childhood acute lymphoblastic leukemia (ALL) survivors.
Surveys were mailed to 5 + -year survivors of childhood ALL aged 13 to 25 years. Survivors' siblings were also invited to participate in the study. Prevalence of back pain and hip pain among ALL survivors was determined and compared with siblings. Sex, treatment with radiation therapy, obesity, and physical activity were examined for an association with back pain and hip pain.
Forty-four of 99 (44.4%) ALL survivors reported back pain compared with 11 of 52 (21.2%) their siblings (P = 0.007; RR: 2.01; 95% confidence interval = 1.15-3.56). In contrast, 10 of 99 (10.1%) ALL survivors reported experiencing hip pain compared with 1 of 52 (2.0%) siblings experiencing hip pain [P = 0.07; RR: 4.95 (0.65 to 37.57)]. Twenty-six of 43 female survivors reported back pain compared with 18 of 56 male survivors who reported back pain (P = 0.005). Obesity, physical activity, and treatment with radiation therapy were not associated with back pain or hip pain.
This is the first study demonstrating an increased frequency of back pain among survivors of childhood ALL. Future studies are needed to better define the causes of back pain among childhood ALL survivors.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Arthralgia - epidemiology</subject><subject>Back Injuries - epidemiology</subject><subject>Back Pain - epidemiology</subject><subject>Female</subject><subject>Health Surveys</subject><subject>Hip Joint</subject><subject>Humans</subject><subject>Male</subject><subject>Motor Activity</subject><subject>Obesity - epidemiology</subject><subject>Precursor Cell Lymphoblastic Leukemia-Lymphoma - therapy</subject><subject>Prevalence</subject><subject>Radiotherapy</subject><subject>Risk</subject><subject>Siblings</subject><subject>Spinal Puncture - adverse effects</subject><subject>Survivors</subject><subject>Young Adult</subject><issn>1077-4114</issn><issn>1536-3678</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkLFOwzAQhi0EoqXwBghlZEm5sx3bGaECigSCAebIcc40NGmK3VTi7QlqYWC5_4bvv5M-xs4Rpgi5vnp6mU-hBBQk0HANBio6YGPMhEqF0uZw2EHrVCLKETuJ8QMAtZD8mI24wIEHMWb5jXXLZG3rVWLbbvWeNMNINxTaJPZhW2-7EJPOJ25RN9Wi66qkoX5JbW1P2ZG3TaSzfU7Y293t62yePj7fP8yuH1MnBN-knEChJ3Q6Nx4QyItcce-UMpRlAkmV2mDmlLeldkJJcLIylTFacSnAiAm73N1dh-6zp7gp2jo6ahq7oq6PBSKXOpPA-YDKHepCF2MgX6xD3drwVSAUP9KKQVrxX9pQu9h_6MuWqr_SryXxDZbtZ0Q</recordid><startdate>20121101</startdate><enddate>20121101</enddate><creator>Bowers, Daniel C</creator><creator>Griffith, Terri</creator><creator>Gargan, Lynn</creator><creator>Cochran, Cindy J</creator><creator>Kleiber, Beverly</creator><creator>Foxwell, Aleksandra</creator><creator>Farrow-Gillespie, Alan</creator><creator>Orlino, Angela</creator><creator>Germann, Julie N</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20121101</creationdate><title>Back pain among long-term survivors of childhood leukemia</title><author>Bowers, Daniel C ; Griffith, Terri ; Gargan, Lynn ; Cochran, Cindy J ; Kleiber, Beverly ; Foxwell, Aleksandra ; Farrow-Gillespie, Alan ; Orlino, Angela ; Germann, Julie N</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c332t-2e061fe1c798f010ef3962fc668e5531e6b7815c6fab7c3640c4d8d8876243083</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Arthralgia - epidemiology</topic><topic>Back Injuries - epidemiology</topic><topic>Back Pain - epidemiology</topic><topic>Female</topic><topic>Health Surveys</topic><topic>Hip Joint</topic><topic>Humans</topic><topic>Male</topic><topic>Motor Activity</topic><topic>Obesity - epidemiology</topic><topic>Precursor Cell Lymphoblastic Leukemia-Lymphoma - therapy</topic><topic>Prevalence</topic><topic>Radiotherapy</topic><topic>Risk</topic><topic>Siblings</topic><topic>Spinal Puncture - adverse effects</topic><topic>Survivors</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bowers, Daniel C</creatorcontrib><creatorcontrib>Griffith, Terri</creatorcontrib><creatorcontrib>Gargan, Lynn</creatorcontrib><creatorcontrib>Cochran, Cindy J</creatorcontrib><creatorcontrib>Kleiber, Beverly</creatorcontrib><creatorcontrib>Foxwell, Aleksandra</creatorcontrib><creatorcontrib>Farrow-Gillespie, Alan</creatorcontrib><creatorcontrib>Orlino, Angela</creatorcontrib><creatorcontrib>Germann, Julie N</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pediatric hematology/oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bowers, Daniel C</au><au>Griffith, Terri</au><au>Gargan, Lynn</au><au>Cochran, Cindy J</au><au>Kleiber, Beverly</au><au>Foxwell, Aleksandra</au><au>Farrow-Gillespie, Alan</au><au>Orlino, Angela</au><au>Germann, Julie N</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Back pain among long-term survivors of childhood leukemia</atitle><jtitle>Journal of pediatric hematology/oncology</jtitle><addtitle>J Pediatr Hematol Oncol</addtitle><date>2012-11-01</date><risdate>2012</risdate><volume>34</volume><issue>8</issue><spage>624</spage><epage>629</epage><pages>624-629</pages><issn>1077-4114</issn><eissn>1536-3678</eissn><abstract>The objectives of this study are to determine the prevalence and relative risk (RR) of back pain and identify possible mechanisms of back pain among childhood acute lymphoblastic leukemia (ALL) survivors.
Surveys were mailed to 5 + -year survivors of childhood ALL aged 13 to 25 years. Survivors' siblings were also invited to participate in the study. Prevalence of back pain and hip pain among ALL survivors was determined and compared with siblings. Sex, treatment with radiation therapy, obesity, and physical activity were examined for an association with back pain and hip pain.
Forty-four of 99 (44.4%) ALL survivors reported back pain compared with 11 of 52 (21.2%) their siblings (P = 0.007; RR: 2.01; 95% confidence interval = 1.15-3.56). In contrast, 10 of 99 (10.1%) ALL survivors reported experiencing hip pain compared with 1 of 52 (2.0%) siblings experiencing hip pain [P = 0.07; RR: 4.95 (0.65 to 37.57)]. Twenty-six of 43 female survivors reported back pain compared with 18 of 56 male survivors who reported back pain (P = 0.005). Obesity, physical activity, and treatment with radiation therapy were not associated with back pain or hip pain.
This is the first study demonstrating an increased frequency of back pain among survivors of childhood ALL. Future studies are needed to better define the causes of back pain among childhood ALL survivors.</abstract><cop>United States</cop><pmid>23108003</pmid><doi>10.1097/MPH.0b013e31827080de</doi><tpages>6</tpages></addata></record> |
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| ispartof | Journal of pediatric hematology/oncology, 2012-11, Vol.34 (8), p.624-629 |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adolescent Adult Arthralgia - epidemiology Back Injuries - epidemiology Back Pain - epidemiology Female Health Surveys Hip Joint Humans Male Motor Activity Obesity - epidemiology Precursor Cell Lymphoblastic Leukemia-Lymphoma - therapy Prevalence Radiotherapy Risk Siblings Spinal Puncture - adverse effects Survivors Young Adult |
| title | Back pain among long-term survivors of childhood leukemia |
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