Mitochondria organelle transplantation: introduction of normal epithelial mitochondria into human cancer cells inhibits proliferation and increases drug sensitivity

Mitochondrial dysfunction of cancer cells includes increased aerobic glycolysis, elevated levels of ROS, decreased apoptosis, and resistance to chemotherapeutic agents. We hypothesized that the introduction of normal mitochondria into cancer cells might restore mitochondrial function and inhibit can...

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Veröffentlicht in:	Breast cancer research and treatment 2012-11, Vol.136 (2), p.347-354
Hauptverfasser:	Elliott, R. L., Jiang, X. P., Head, J. F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anthracyclines Apoptosis Biological and medical sciences Breast cancer Breast Neoplasms - metabolism Cancer Cancer cells Cancer research Cancer therapies Cell Line, Tumor Cell Proliferation Chemotherapy Drug resistance Drug Resistance, Neoplasm Drug therapy Epithelial Cells - chemistry Epithelial Cells - metabolism Female Glucose metabolism Gynecology. Andrology. Obstetrics Humans Mammary gland diseases Mammary Glands, Human MCF-7 Cells Medical sciences Medicine Medicine & Public Health Mitochondria Mitochondria - metabolism Mitochondria - transplantation Mitochondrial DNA Oncology Review Transplants & implants Tumors
Online-Zugang:	Volltext
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