Sex-hormone-binding globulin early in pregnancy for the prediction of severe gestational diabetes mellitus and related complications
Aims: The aim of this study was to evaluate the predictive value of sex‐hormone‐binding globulin (SHBG) for the diagnosis of gestational diabetes mellitus (GDM), and to clarify the association between SHBG levels and GDM complications/medication requirements. Material and Methods: Among the partic...
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| Veröffentlicht in: | The journal of obstetrics and gynaecology research 2012-11, Vol.38 (11), p.1286-1293 |
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| container_title | The journal of obstetrics and gynaecology research |
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| creator | Caglar, Gamze S. Ozdemir, Elif D. U. Cengiz, Sevim D. Demirtaş, Selda |
| description | Aims: The aim of this study was to evaluate the predictive value of sex‐hormone‐binding globulin (SHBG) for the diagnosis of gestational diabetes mellitus (GDM), and to clarify the association between SHBG levels and GDM complications/medication requirements.
Material and Methods: Among the participants (n = 93) who provided blood samples between 13 and 16 weeks' gestation, 30 cases subsequently developed GDM. Complications and medical interventions were noted. The best cut‐off point of SHBG and diagnostic performance were calculated.
Results: The mean age was 28.45 ± 5.0 years. SHBG levels were lower in the GDM group (n = 30) when compared with non‐GDM (n = 63) cases ( |
| doi_str_mv | 10.1111/j.1447-0756.2012.01870.x |
| format | Article |
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Material and Methods: Among the participants (n = 93) who provided blood samples between 13 and 16 weeks' gestation, 30 cases subsequently developed GDM. Complications and medical interventions were noted. The best cut‐off point of SHBG and diagnostic performance were calculated.
Results: The mean age was 28.45 ± 5.0 years. SHBG levels were lower in the GDM group (n = 30) when compared with non‐GDM (n = 63) cases (<0.01). Among the GDM women, SHBG was lower in the insulin therapy group (n = 15) compared with medical nutritional therapy alone (n = 15) (P < 0.01). A good predictive accuracy of SHBG was found for GDM requiring insulin therapy (area under the curve: 0.866, 95% confidence interval: 0.773–0.959). An SHBG threshold for 97.47 nmol/L had a sensitivity of 80.0%, specificity 84.6%, positive predictive value 50.0% and negative predictive value 95.7%. The calculated odds ratio for SHBG < 97.47 nmol/L was 12.346 (95% confidence interval: 1.786–83.33).
Conclusions: SHBG is valuable for screening women early in pregnancy for GDM risk; however, a standard assay for analyses and a threshold level of serum SHBG for a constant gestational week has to be determined.</description><identifier>ISSN: 1341-8076</identifier><identifier>EISSN: 1447-0756</identifier><identifier>DOI: 10.1111/j.1447-0756.2012.01870.x</identifier><identifier>PMID: 22612716</identifier><language>eng</language><publisher>Melbourne, Australia: Blackwell Publishing Asia</publisher><subject>Adult ; Biomarkers - blood ; Cross-Sectional Studies ; Decision Support Techniques ; Diabetes, Gestational - blood ; Diabetes, Gestational - diagnosis ; Female ; gestational diabetes mellitus ; Humans ; insulin therapy ; Logistic Models ; perinatal outcome ; prediction of gestational diabetes ; Predictive Value of Tests ; Pregnancy ; Pregnancy Trimester, First - blood ; Pregnancy Trimester, Second - blood ; Prospective Studies ; Sensitivity and Specificity ; Severity of Illness Index ; Sex Hormone-Binding Globulin - metabolism ; sex-hormone-binding globulin</subject><ispartof>The journal of obstetrics and gynaecology research, 2012-11, Vol.38 (11), p.1286-1293</ispartof><rights>2012 The Authors. Journal of Obstetrics and Gynaecology Research © 2012 Japan Society of Obstetrics and Gynecology</rights><rights>2012 The Authors. Journal of Obstetrics and Gynaecology Research © 2012 Japan Society of Obstetrics and Gynecology.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4810-e7143e12ce6ab88c52062141790068f6426efe9c640196fba246228bff00768d3</citedby><cites>FETCH-LOGICAL-c4810-e7143e12ce6ab88c52062141790068f6426efe9c640196fba246228bff00768d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1447-0756.2012.01870.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1447-0756.2012.01870.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22612716$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Caglar, Gamze S.</creatorcontrib><creatorcontrib>Ozdemir, Elif D. U.</creatorcontrib><creatorcontrib>Cengiz, Sevim D.</creatorcontrib><creatorcontrib>Demirtaş, Selda</creatorcontrib><title>Sex-hormone-binding globulin early in pregnancy for the prediction of severe gestational diabetes mellitus and related complications</title><title>The journal of obstetrics and gynaecology research</title><addtitle>J Obstet Gynaecol Res</addtitle><description>Aims: The aim of this study was to evaluate the predictive value of sex‐hormone‐binding globulin (SHBG) for the diagnosis of gestational diabetes mellitus (GDM), and to clarify the association between SHBG levels and GDM complications/medication requirements.
Material and Methods: Among the participants (n = 93) who provided blood samples between 13 and 16 weeks' gestation, 30 cases subsequently developed GDM. Complications and medical interventions were noted. The best cut‐off point of SHBG and diagnostic performance were calculated.
Results: The mean age was 28.45 ± 5.0 years. SHBG levels were lower in the GDM group (n = 30) when compared with non‐GDM (n = 63) cases (<0.01). Among the GDM women, SHBG was lower in the insulin therapy group (n = 15) compared with medical nutritional therapy alone (n = 15) (P < 0.01). A good predictive accuracy of SHBG was found for GDM requiring insulin therapy (area under the curve: 0.866, 95% confidence interval: 0.773–0.959). An SHBG threshold for 97.47 nmol/L had a sensitivity of 80.0%, specificity 84.6%, positive predictive value 50.0% and negative predictive value 95.7%. The calculated odds ratio for SHBG < 97.47 nmol/L was 12.346 (95% confidence interval: 1.786–83.33).
Conclusions: SHBG is valuable for screening women early in pregnancy for GDM risk; however, a standard assay for analyses and a threshold level of serum SHBG for a constant gestational week has to be determined.</description><subject>Adult</subject><subject>Biomarkers - blood</subject><subject>Cross-Sectional Studies</subject><subject>Decision Support Techniques</subject><subject>Diabetes, Gestational - blood</subject><subject>Diabetes, Gestational - diagnosis</subject><subject>Female</subject><subject>gestational diabetes mellitus</subject><subject>Humans</subject><subject>insulin therapy</subject><subject>Logistic Models</subject><subject>perinatal outcome</subject><subject>prediction of gestational diabetes</subject><subject>Predictive Value of Tests</subject><subject>Pregnancy</subject><subject>Pregnancy Trimester, First - blood</subject><subject>Pregnancy Trimester, Second - blood</subject><subject>Prospective Studies</subject><subject>Sensitivity and Specificity</subject><subject>Severity of Illness Index</subject><subject>Sex Hormone-Binding Globulin - metabolism</subject><subject>sex-hormone-binding globulin</subject><issn>1341-8076</issn><issn>1447-0756</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUcFuEzEUtBCIlsIvIB-57GJ7Hds5cEAFEqqqlaCIo-X1PqcO3nWwdyG58-F4m5Izvnj0PPPe8wxCmJKalvN2W1POZUXkQtSMUFYTqiSp90_Q-enhacENp5UiUpyhFzlvCaFySdVzdMaYoExScY7-fIV9dR9THweoWj90ftjgTYjtFPyAwaRwwAXsEmwGM9gDdjHh8R7mSuft6OOAo8MZfkECvIE8mrlmAu68aWGEjHsIwY9TxmbocIJgRuiwjf0uePtAzi_RM2dChleP9wX69unj3eW6ur5dfb58f11ZriipQFLeAGUWhGmVsgtGBKO8fIoQoZzgTICDpRWc0KVwrWFcMKZa50jxQHXNBXpz7LtL8edUdtW9z7asZwaIU9aUMi4XZQgpVHWk2hRzTuD0LvnepIOmRM8Z6K2erdaz1XrOQD9koPdF-vpxytT20J2E_0wvhHdHwm8f4PDfjfXV7WpGRV8d9T6PsD_pTfqhhWzkQn-_WWn15Wr94eZurdfNX-DKpkg</recordid><startdate>201211</startdate><enddate>201211</enddate><creator>Caglar, Gamze S.</creator><creator>Ozdemir, Elif D. U.</creator><creator>Cengiz, Sevim D.</creator><creator>Demirtaş, Selda</creator><general>Blackwell Publishing Asia</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201211</creationdate><title>Sex-hormone-binding globulin early in pregnancy for the prediction of severe gestational diabetes mellitus and related complications</title><author>Caglar, Gamze S. ; Ozdemir, Elif D. U. ; Cengiz, Sevim D. ; Demirtaş, Selda</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4810-e7143e12ce6ab88c52062141790068f6426efe9c640196fba246228bff00768d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Biomarkers - blood</topic><topic>Cross-Sectional Studies</topic><topic>Decision Support Techniques</topic><topic>Diabetes, Gestational - blood</topic><topic>Diabetes, Gestational - diagnosis</topic><topic>Female</topic><topic>gestational diabetes mellitus</topic><topic>Humans</topic><topic>insulin therapy</topic><topic>Logistic Models</topic><topic>perinatal outcome</topic><topic>prediction of gestational diabetes</topic><topic>Predictive Value of Tests</topic><topic>Pregnancy</topic><topic>Pregnancy Trimester, First - blood</topic><topic>Pregnancy Trimester, Second - blood</topic><topic>Prospective Studies</topic><topic>Sensitivity and Specificity</topic><topic>Severity of Illness Index</topic><topic>Sex Hormone-Binding Globulin - metabolism</topic><topic>sex-hormone-binding globulin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Caglar, Gamze S.</creatorcontrib><creatorcontrib>Ozdemir, Elif D. U.</creatorcontrib><creatorcontrib>Cengiz, Sevim D.</creatorcontrib><creatorcontrib>Demirtaş, Selda</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The journal of obstetrics and gynaecology research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Caglar, Gamze S.</au><au>Ozdemir, Elif D. U.</au><au>Cengiz, Sevim D.</au><au>Demirtaş, Selda</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sex-hormone-binding globulin early in pregnancy for the prediction of severe gestational diabetes mellitus and related complications</atitle><jtitle>The journal of obstetrics and gynaecology research</jtitle><addtitle>J Obstet Gynaecol Res</addtitle><date>2012-11</date><risdate>2012</risdate><volume>38</volume><issue>11</issue><spage>1286</spage><epage>1293</epage><pages>1286-1293</pages><issn>1341-8076</issn><eissn>1447-0756</eissn><abstract>Aims: The aim of this study was to evaluate the predictive value of sex‐hormone‐binding globulin (SHBG) for the diagnosis of gestational diabetes mellitus (GDM), and to clarify the association between SHBG levels and GDM complications/medication requirements.
Material and Methods: Among the participants (n = 93) who provided blood samples between 13 and 16 weeks' gestation, 30 cases subsequently developed GDM. Complications and medical interventions were noted. The best cut‐off point of SHBG and diagnostic performance were calculated.
Results: The mean age was 28.45 ± 5.0 years. SHBG levels were lower in the GDM group (n = 30) when compared with non‐GDM (n = 63) cases (<0.01). Among the GDM women, SHBG was lower in the insulin therapy group (n = 15) compared with medical nutritional therapy alone (n = 15) (P < 0.01). A good predictive accuracy of SHBG was found for GDM requiring insulin therapy (area under the curve: 0.866, 95% confidence interval: 0.773–0.959). An SHBG threshold for 97.47 nmol/L had a sensitivity of 80.0%, specificity 84.6%, positive predictive value 50.0% and negative predictive value 95.7%. The calculated odds ratio for SHBG < 97.47 nmol/L was 12.346 (95% confidence interval: 1.786–83.33).
Conclusions: SHBG is valuable for screening women early in pregnancy for GDM risk; however, a standard assay for analyses and a threshold level of serum SHBG for a constant gestational week has to be determined.</abstract><cop>Melbourne, Australia</cop><pub>Blackwell Publishing Asia</pub><pmid>22612716</pmid><doi>10.1111/j.1447-0756.2012.01870.x</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Biomarkers - blood Cross-Sectional Studies Decision Support Techniques Diabetes, Gestational - blood Diabetes, Gestational - diagnosis Female gestational diabetes mellitus Humans insulin therapy Logistic Models perinatal outcome prediction of gestational diabetes Predictive Value of Tests Pregnancy Pregnancy Trimester, First - blood Pregnancy Trimester, Second - blood Prospective Studies Sensitivity and Specificity Severity of Illness Index Sex Hormone-Binding Globulin - metabolism sex-hormone-binding globulin |
| title | Sex-hormone-binding globulin early in pregnancy for the prediction of severe gestational diabetes mellitus and related complications |
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