Low-level-laser irradiation induces photorelaxation in coronary arteries and overcomes vasospasm of internal thoracic arteries
Background and Objective As low‐level laser irradiation (LLLI) seems to induce vasodilation besides many other known biological effects, LLLI has been increasingly used in therapy of medical conditions with various irradiation parameters. The aim of this study was to investigate the effect of LLLI o...
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| Veröffentlicht in: | Lasers in surgery and medicine 2012-11, Vol.44 (9), p.705-711 |
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| creator | Plass, Christian A. Wieselthaler, Georg M. Podesser, Bruno K. Prusa, Alexander M. |
| description | Background and Objective
As low‐level laser irradiation (LLLI) seems to induce vasodilation besides many other known biological effects, LLLI has been increasingly used in therapy of medical conditions with various irradiation parameters. The aim of this study was to investigate the effect of LLLI on photorelaxation of human coronary and internal thoracic arteries (ITA).
Materials and Methods
Thirty vessel segments of ITA used for routine coronary artery bypass grafting as well as left anterior descending coronary arteries (LAD) of patients undergoing cardiac transplantation were cut into 4‐mm rings stored in a modified Krebs–Henseleit solution and evaluated in a myograph. Both types of vessel segments were irradiated by a semiconductor non‐thermal GaAs diode laser operating at a wavelength of 680 nm. After precontraction with thromboxane agonist U44619, respective relaxation responses were evaluated and compared to pharmacological dilatation induced by substance P.
Results
Mean pharmacological vasodilation by substance P was 22.6 ± 3.3%, 12.8 ± 1.4%, and 20.4 ± 3.2% in macroscopic healthy LAD, LAD with atheromatous plaque, and ITA, respectively. Average photorelaxation induced by LLLI was 16.5 ± 2.0%, 1.9 ± 1.7%, and 6.8 ± 4.7%, accordingly. Vasodilatatory responses induced either by substance P or administration of LLLI were significantly decreased in LAD with atheromatous plaque (P |
| doi_str_mv | 10.1002/lsm.22075 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1124750563</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1124750563</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3635-5d88754ea4fbc7eb6314c38bd72e736caa064bffc373027e9b98bd772c19d7633</originalsourceid><addsrcrecordid>eNp10M1O3DAUBWALtYIpZcELVFmWReDaTuLJElFKK4WiqlRIbKwb50a4OPHUzgyw6bPXMMzsWPnvu0fyYeyQwzEHECcuDsdCgCp32IxDXeU1B_6OzYCn_Rxqscc-xPgHAGRSu2xPSABV82rG_jX-IXe0Ipc7jBQyGwJ2Fifrx8yO3dJQzBZ3fvKBHD5u7jPjgx8xPGUYJgo2IRy7zK8oGD-k0wqjjwuMQ-b75JMZ0WXTnQ9orNlOfWTve3SRDl7Xffb76_n12be8ubr4fnba5EZWsszLbj5XZUFY9K1R1FaSF0bO204JUrIyiFAVbd8bqSQIRXVbPz8qYXjdqUrKffZ5nbsI_u-S4qQHGw05hyP5ZdSci0KVUL7QozU1wccYqNeLYIf0Vc1BP9etU936pe5kP73GLtuBuq3c9JvAyRo8WEdPbyfp5tflJjJfT9g40eN2AsO9rpRM8ubHhS4v62v42dzqL_I_RY6cHw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1124750563</pqid></control><display><type>article</type><title>Low-level-laser irradiation induces photorelaxation in coronary arteries and overcomes vasospasm of internal thoracic arteries</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Plass, Christian A. ; Wieselthaler, Georg M. ; Podesser, Bruno K. ; Prusa, Alexander M.</creator><creatorcontrib>Plass, Christian A. ; Wieselthaler, Georg M. ; Podesser, Bruno K. ; Prusa, Alexander M.</creatorcontrib><description>Background and Objective
As low‐level laser irradiation (LLLI) seems to induce vasodilation besides many other known biological effects, LLLI has been increasingly used in therapy of medical conditions with various irradiation parameters. The aim of this study was to investigate the effect of LLLI on photorelaxation of human coronary and internal thoracic arteries (ITA).
Materials and Methods
Thirty vessel segments of ITA used for routine coronary artery bypass grafting as well as left anterior descending coronary arteries (LAD) of patients undergoing cardiac transplantation were cut into 4‐mm rings stored in a modified Krebs–Henseleit solution and evaluated in a myograph. Both types of vessel segments were irradiated by a semiconductor non‐thermal GaAs diode laser operating at a wavelength of 680 nm. After precontraction with thromboxane agonist U44619, respective relaxation responses were evaluated and compared to pharmacological dilatation induced by substance P.
Results
Mean pharmacological vasodilation by substance P was 22.6 ± 3.3%, 12.8 ± 1.4%, and 20.4 ± 3.2% in macroscopic healthy LAD, LAD with atheromatous plaque, and ITA, respectively. Average photorelaxation induced by LLLI was 16.5 ± 2.0%, 1.9 ± 1.7%, and 6.8 ± 4.7%, accordingly. Vasodilatatory responses induced either by substance P or administration of LLLI were significantly decreased in LAD with atheromatous plaque (P < 0.0001). Vasospasms of ITA segments occurring during experiments could be abandoned when LLLI was administered.
Conclusion
Macroscopic healthy LAD exposed to LLLI revealed significant photorelaxation. With the administration of LLLI, 73% of the maximal obtainable effect by an endothelium‐dependent vasodilator could be reached. Furthermore, LLLI has the potential to overcome vasospasms of ITA. Lasers Surg. Med. 44: 705–711, 2012. © 2012 Wiley Periodicals, Inc.</description><identifier>ISSN: 0196-8092</identifier><identifier>EISSN: 1096-9101</identifier><identifier>DOI: 10.1002/lsm.22075</identifier><identifier>PMID: 23007916</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid - pharmacology ; Aged ; coronary artery bypass grafting ; Coronary Vessels - drug effects ; Coronary Vessels - physiology ; Coronary Vessels - radiation effects ; endothelium ; Female ; Humans ; In Vitro Techniques ; Lasers, Semiconductor ; Male ; Mammary Arteries - drug effects ; Mammary Arteries - physiology ; Mammary Arteries - radiation effects ; Middle Aged ; Neurotransmitter Agents - pharmacology ; substance P ; Substance P - pharmacology ; Vasoconstriction - drug effects ; Vasoconstriction - radiation effects ; Vasoconstrictor Agents - pharmacology ; vasodilation ; Vasodilation - drug effects ; Vasodilation - radiation effects</subject><ispartof>Lasers in surgery and medicine, 2012-11, Vol.44 (9), p.705-711</ispartof><rights>Copyright © 2012 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3635-5d88754ea4fbc7eb6314c38bd72e736caa064bffc373027e9b98bd772c19d7633</citedby><cites>FETCH-LOGICAL-c3635-5d88754ea4fbc7eb6314c38bd72e736caa064bffc373027e9b98bd772c19d7633</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Flsm.22075$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Flsm.22075$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23007916$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Plass, Christian A.</creatorcontrib><creatorcontrib>Wieselthaler, Georg M.</creatorcontrib><creatorcontrib>Podesser, Bruno K.</creatorcontrib><creatorcontrib>Prusa, Alexander M.</creatorcontrib><title>Low-level-laser irradiation induces photorelaxation in coronary arteries and overcomes vasospasm of internal thoracic arteries</title><title>Lasers in surgery and medicine</title><addtitle>Lasers Surg. Med</addtitle><description>Background and Objective
As low‐level laser irradiation (LLLI) seems to induce vasodilation besides many other known biological effects, LLLI has been increasingly used in therapy of medical conditions with various irradiation parameters. The aim of this study was to investigate the effect of LLLI on photorelaxation of human coronary and internal thoracic arteries (ITA).
Materials and Methods
Thirty vessel segments of ITA used for routine coronary artery bypass grafting as well as left anterior descending coronary arteries (LAD) of patients undergoing cardiac transplantation were cut into 4‐mm rings stored in a modified Krebs–Henseleit solution and evaluated in a myograph. Both types of vessel segments were irradiated by a semiconductor non‐thermal GaAs diode laser operating at a wavelength of 680 nm. After precontraction with thromboxane agonist U44619, respective relaxation responses were evaluated and compared to pharmacological dilatation induced by substance P.
Results
Mean pharmacological vasodilation by substance P was 22.6 ± 3.3%, 12.8 ± 1.4%, and 20.4 ± 3.2% in macroscopic healthy LAD, LAD with atheromatous plaque, and ITA, respectively. Average photorelaxation induced by LLLI was 16.5 ± 2.0%, 1.9 ± 1.7%, and 6.8 ± 4.7%, accordingly. Vasodilatatory responses induced either by substance P or administration of LLLI were significantly decreased in LAD with atheromatous plaque (P < 0.0001). Vasospasms of ITA segments occurring during experiments could be abandoned when LLLI was administered.
Conclusion
Macroscopic healthy LAD exposed to LLLI revealed significant photorelaxation. With the administration of LLLI, 73% of the maximal obtainable effect by an endothelium‐dependent vasodilator could be reached. Furthermore, LLLI has the potential to overcome vasospasms of ITA. Lasers Surg. Med. 44: 705–711, 2012. © 2012 Wiley Periodicals, Inc.</description><subject>15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid - pharmacology</subject><subject>Aged</subject><subject>coronary artery bypass grafting</subject><subject>Coronary Vessels - drug effects</subject><subject>Coronary Vessels - physiology</subject><subject>Coronary Vessels - radiation effects</subject><subject>endothelium</subject><subject>Female</subject><subject>Humans</subject><subject>In Vitro Techniques</subject><subject>Lasers, Semiconductor</subject><subject>Male</subject><subject>Mammary Arteries - drug effects</subject><subject>Mammary Arteries - physiology</subject><subject>Mammary Arteries - radiation effects</subject><subject>Middle Aged</subject><subject>Neurotransmitter Agents - pharmacology</subject><subject>substance P</subject><subject>Substance P - pharmacology</subject><subject>Vasoconstriction - drug effects</subject><subject>Vasoconstriction - radiation effects</subject><subject>Vasoconstrictor Agents - pharmacology</subject><subject>vasodilation</subject><subject>Vasodilation - drug effects</subject><subject>Vasodilation - radiation effects</subject><issn>0196-8092</issn><issn>1096-9101</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10M1O3DAUBWALtYIpZcELVFmWReDaTuLJElFKK4WiqlRIbKwb50a4OPHUzgyw6bPXMMzsWPnvu0fyYeyQwzEHECcuDsdCgCp32IxDXeU1B_6OzYCn_Rxqscc-xPgHAGRSu2xPSABV82rG_jX-IXe0Ipc7jBQyGwJ2Fifrx8yO3dJQzBZ3fvKBHD5u7jPjgx8xPGUYJgo2IRy7zK8oGD-k0wqjjwuMQ-b75JMZ0WXTnQ9orNlOfWTve3SRDl7Xffb76_n12be8ubr4fnba5EZWsszLbj5XZUFY9K1R1FaSF0bO204JUrIyiFAVbd8bqSQIRXVbPz8qYXjdqUrKffZ5nbsI_u-S4qQHGw05hyP5ZdSci0KVUL7QozU1wccYqNeLYIf0Vc1BP9etU936pe5kP73GLtuBuq3c9JvAyRo8WEdPbyfp5tflJjJfT9g40eN2AsO9rpRM8ubHhS4v62v42dzqL_I_RY6cHw</recordid><startdate>201211</startdate><enddate>201211</enddate><creator>Plass, Christian A.</creator><creator>Wieselthaler, Georg M.</creator><creator>Podesser, Bruno K.</creator><creator>Prusa, Alexander M.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201211</creationdate><title>Low-level-laser irradiation induces photorelaxation in coronary arteries and overcomes vasospasm of internal thoracic arteries</title><author>Plass, Christian A. ; Wieselthaler, Georg M. ; Podesser, Bruno K. ; Prusa, Alexander M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3635-5d88754ea4fbc7eb6314c38bd72e736caa064bffc373027e9b98bd772c19d7633</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid - pharmacology</topic><topic>Aged</topic><topic>coronary artery bypass grafting</topic><topic>Coronary Vessels - drug effects</topic><topic>Coronary Vessels - physiology</topic><topic>Coronary Vessels - radiation effects</topic><topic>endothelium</topic><topic>Female</topic><topic>Humans</topic><topic>In Vitro Techniques</topic><topic>Lasers, Semiconductor</topic><topic>Male</topic><topic>Mammary Arteries - drug effects</topic><topic>Mammary Arteries - physiology</topic><topic>Mammary Arteries - radiation effects</topic><topic>Middle Aged</topic><topic>Neurotransmitter Agents - pharmacology</topic><topic>substance P</topic><topic>Substance P - pharmacology</topic><topic>Vasoconstriction - drug effects</topic><topic>Vasoconstriction - radiation effects</topic><topic>Vasoconstrictor Agents - pharmacology</topic><topic>vasodilation</topic><topic>Vasodilation - drug effects</topic><topic>Vasodilation - radiation effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Plass, Christian A.</creatorcontrib><creatorcontrib>Wieselthaler, Georg M.</creatorcontrib><creatorcontrib>Podesser, Bruno K.</creatorcontrib><creatorcontrib>Prusa, Alexander M.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Lasers in surgery and medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Plass, Christian A.</au><au>Wieselthaler, Georg M.</au><au>Podesser, Bruno K.</au><au>Prusa, Alexander M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Low-level-laser irradiation induces photorelaxation in coronary arteries and overcomes vasospasm of internal thoracic arteries</atitle><jtitle>Lasers in surgery and medicine</jtitle><addtitle>Lasers Surg. Med</addtitle><date>2012-11</date><risdate>2012</risdate><volume>44</volume><issue>9</issue><spage>705</spage><epage>711</epage><pages>705-711</pages><issn>0196-8092</issn><eissn>1096-9101</eissn><abstract>Background and Objective
As low‐level laser irradiation (LLLI) seems to induce vasodilation besides many other known biological effects, LLLI has been increasingly used in therapy of medical conditions with various irradiation parameters. The aim of this study was to investigate the effect of LLLI on photorelaxation of human coronary and internal thoracic arteries (ITA).
Materials and Methods
Thirty vessel segments of ITA used for routine coronary artery bypass grafting as well as left anterior descending coronary arteries (LAD) of patients undergoing cardiac transplantation were cut into 4‐mm rings stored in a modified Krebs–Henseleit solution and evaluated in a myograph. Both types of vessel segments were irradiated by a semiconductor non‐thermal GaAs diode laser operating at a wavelength of 680 nm. After precontraction with thromboxane agonist U44619, respective relaxation responses were evaluated and compared to pharmacological dilatation induced by substance P.
Results
Mean pharmacological vasodilation by substance P was 22.6 ± 3.3%, 12.8 ± 1.4%, and 20.4 ± 3.2% in macroscopic healthy LAD, LAD with atheromatous plaque, and ITA, respectively. Average photorelaxation induced by LLLI was 16.5 ± 2.0%, 1.9 ± 1.7%, and 6.8 ± 4.7%, accordingly. Vasodilatatory responses induced either by substance P or administration of LLLI were significantly decreased in LAD with atheromatous plaque (P < 0.0001). Vasospasms of ITA segments occurring during experiments could be abandoned when LLLI was administered.
Conclusion
Macroscopic healthy LAD exposed to LLLI revealed significant photorelaxation. With the administration of LLLI, 73% of the maximal obtainable effect by an endothelium‐dependent vasodilator could be reached. Furthermore, LLLI has the potential to overcome vasospasms of ITA. Lasers Surg. Med. 44: 705–711, 2012. © 2012 Wiley Periodicals, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>23007916</pmid><doi>10.1002/lsm.22075</doi><tpages>7</tpages></addata></record> |
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| subjects | 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid - pharmacology Aged coronary artery bypass grafting Coronary Vessels - drug effects Coronary Vessels - physiology Coronary Vessels - radiation effects endothelium Female Humans In Vitro Techniques Lasers, Semiconductor Male Mammary Arteries - drug effects Mammary Arteries - physiology Mammary Arteries - radiation effects Middle Aged Neurotransmitter Agents - pharmacology substance P Substance P - pharmacology Vasoconstriction - drug effects Vasoconstriction - radiation effects Vasoconstrictor Agents - pharmacology vasodilation Vasodilation - drug effects Vasodilation - radiation effects |
| title | Low-level-laser irradiation induces photorelaxation in coronary arteries and overcomes vasospasm of internal thoracic arteries |
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