The heme oxygenase–carbon monoxide system in the regulation of cardiorespiratory function at high altitude

Highlights ► Pulmonary hypertension could affect people living at high altitudes over 2500 m. ► Neonatal llama has neither pulmonary hypertension in highlands nor vessels remodeling. ► The highland llama neonate increases HO-1 expression and CO production by the lung. ► The HO–CO system participates...

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Veröffentlicht in:	Respiratory physiology & neurobiology 2012-11, Vol.184 (2), p.186-191
Hauptverfasser:	Llanos, Aníbal J, Ebensperger, Germán, Herrera, Emilio A, Reyes, Roberto V, Cabello, Gertrudis, Díaz, Marcela, Giussani, Dino A, Parer, Julian T
Format:	Artikel
Sprache:	eng
Schlagworte:	Acclimatization - physiology Altitude Animals Animals, Newborn Camelids, New World Carbon monoxide Carbon Monoxide - physiology Cardiovascular Physiological Phenomena CORM Female Heme oxygenase Heme Oxygenase (Decyclizing) - physiology hypoxia Medical Education Pregnancy Pulmonary vasodilatation Pulmonary/Respiratory Respiratory Physiological Phenomena Sheep Vascular remodeling
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Zusammenfassung:	Highlights ► Pulmonary hypertension could affect people living at high altitudes over 2500 m. ► Neonatal llama has neither pulmonary hypertension in highlands nor vessels remodeling. ► The highland llama neonate increases HO-1 expression and CO production by the lung. ► The HO–CO system participates in the control of the lung circulation in the llama. ► The highland neonatal sheep decreases HO-1 expression and CO production by the lung.
ISSN:	1569-9048 1878-1519
DOI:	10.1016/j.resp.2012.05.003