Source of angiopoietin-2 in the sera of women during pregnancy
Placental development requires coordinated angiogenesis regulated by multiple factors including angiopoietins. Previously we demonstrated that the concentration of angiopoietin-2 (Ang-2) in the sera of women rises markedly in pregnancy in early gestation. This increase is reduced in pregnancies subs...
Gespeichert in:
| Veröffentlicht in: | Microvascular research 2012-11, Vol.84 (3), p.367-374 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 374 |
|---|---|
| container_issue | 3 |
| container_start_page | 367 |
| container_title | Microvascular research |
| container_volume | 84 |
| creator | Woolnough, C. Wang, Y. Kan, C.Y. Morris, J.M. Tasevski, V. Ashton, A.W. |
| description | Placental development requires coordinated angiogenesis regulated by multiple factors including angiopoietins. Previously we demonstrated that the concentration of angiopoietin-2 (Ang-2) in the sera of women rises markedly in pregnancy in early gestation. This increase is reduced in pregnancies subsequently complicated by intrauterine growth restriction (IUGR). We now show that the concentration of Ang-2, but not Ang-1, in maternal serum is increased during normal pregnancy, peaking at the end of the first trimester. We also demonstrate that a key source of the elevated Ang-2 levels during pregnancy is decidual endothelial cells (DECs) but not cytotrophoblasts. Secretion of Ang-2 by DECs relies on the release from intracellular stores and the synthesis of new Ang-2 protein and is regulated by serum factors at a translational level. Further studies on the role of Ang-2 during pregnancy are warranted as well as the evaluation of Ang-2 as a marker to predict adverse pregnancy outcomes.
► Ang-2, but not Ang-1, is elevated in maternal serum compared to non-pregnant serum. ► The key source of the elevated Ang-2 during pregnancy is decidual endothelial cells. ► Ang-2 release by DECs relies on intracellular stores and newly synthesized protein. ► The pregnancy-induced rise in Ang-2 in maternal sera is attenuated in IUGR. |
| doi_str_mv | 10.1016/j.mvr.2012.08.003 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1122606373</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0026286212001525</els_id><sourcerecordid>1122606373</sourcerecordid><originalsourceid>FETCH-LOGICAL-c353t-fbc05eb69667a68ed7d36eff72eee3b17179a947d5068a55085ea286c905a16b3</originalsourceid><addsrcrecordid>eNp9kE1LxDAQhoMoun78AC_So5fWSWLSBkGQxS8QPKjnkKbTNcs2qUmr-O_tsqtHT3OY532ZeQg5pVBQoPJiWXSfsWBAWQFVAcB3yIyCErniVO2SGQCTOaskOyCHKS0BKBWK7ZMDxpQSVQkzcv0SxmgxC21m_MKFPjgcnM9Z5nw2vGOWMJr19it06LNmjM4vsj7iwhtvv4_JXmtWCU-284i83d2-zh_yp-f7x_nNU2654EPe1hYE1lJJWRpZYVM2XGLblgwReU1LWiqjLstGgKyMEFAJNNPhVoEwVNb8iJxvevsYPkZMg-5csrhaGY9hTJpSxiRIXvIJpRvUxpBSxFb30XUmfmsKeq1NL_WkTa-1aaj0pG3KnG3rx7rD5i_x62kCrjYATk9-Oow6WYfeYuMi2kE3wf1T_wPK13yN</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1122606373</pqid></control><display><type>article</type><title>Source of angiopoietin-2 in the sera of women during pregnancy</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Woolnough, C. ; Wang, Y. ; Kan, C.Y. ; Morris, J.M. ; Tasevski, V. ; Ashton, A.W.</creator><creatorcontrib>Woolnough, C. ; Wang, Y. ; Kan, C.Y. ; Morris, J.M. ; Tasevski, V. ; Ashton, A.W.</creatorcontrib><description>Placental development requires coordinated angiogenesis regulated by multiple factors including angiopoietins. Previously we demonstrated that the concentration of angiopoietin-2 (Ang-2) in the sera of women rises markedly in pregnancy in early gestation. This increase is reduced in pregnancies subsequently complicated by intrauterine growth restriction (IUGR). We now show that the concentration of Ang-2, but not Ang-1, in maternal serum is increased during normal pregnancy, peaking at the end of the first trimester. We also demonstrate that a key source of the elevated Ang-2 levels during pregnancy is decidual endothelial cells (DECs) but not cytotrophoblasts. Secretion of Ang-2 by DECs relies on the release from intracellular stores and the synthesis of new Ang-2 protein and is regulated by serum factors at a translational level. Further studies on the role of Ang-2 during pregnancy are warranted as well as the evaluation of Ang-2 as a marker to predict adverse pregnancy outcomes.
► Ang-2, but not Ang-1, is elevated in maternal serum compared to non-pregnant serum. ► The key source of the elevated Ang-2 during pregnancy is decidual endothelial cells. ► Ang-2 release by DECs relies on intracellular stores and newly synthesized protein. ► The pregnancy-induced rise in Ang-2 in maternal sera is attenuated in IUGR.</description><identifier>ISSN: 0026-2862</identifier><identifier>EISSN: 1095-9319</identifier><identifier>DOI: 10.1016/j.mvr.2012.08.003</identifier><identifier>PMID: 22995870</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Angiopoietin-1 - blood ; Angiopoietin-2 - blood ; Decidua - pathology ; Enzyme-Linked Immunosorbent Assay - methods ; Female ; Fetal Growth Retardation - blood ; Gene Expression Regulation ; Humans ; Immunoglobulin G - metabolism ; Keratin-7 - biosynthesis ; Placenta - metabolism ; Platelet Endothelial Cell Adhesion Molecule-1 - biosynthesis ; Pregnancy ; Pregnancy Outcome ; Pregnancy Trimester, First ; Trophoblasts - cytology</subject><ispartof>Microvascular research, 2012-11, Vol.84 (3), p.367-374</ispartof><rights>2012</rights><rights>Crown Copyright © 2012. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c353t-fbc05eb69667a68ed7d36eff72eee3b17179a947d5068a55085ea286c905a16b3</citedby><cites>FETCH-LOGICAL-c353t-fbc05eb69667a68ed7d36eff72eee3b17179a947d5068a55085ea286c905a16b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0026286212001525$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22995870$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Woolnough, C.</creatorcontrib><creatorcontrib>Wang, Y.</creatorcontrib><creatorcontrib>Kan, C.Y.</creatorcontrib><creatorcontrib>Morris, J.M.</creatorcontrib><creatorcontrib>Tasevski, V.</creatorcontrib><creatorcontrib>Ashton, A.W.</creatorcontrib><title>Source of angiopoietin-2 in the sera of women during pregnancy</title><title>Microvascular research</title><addtitle>Microvasc Res</addtitle><description>Placental development requires coordinated angiogenesis regulated by multiple factors including angiopoietins. Previously we demonstrated that the concentration of angiopoietin-2 (Ang-2) in the sera of women rises markedly in pregnancy in early gestation. This increase is reduced in pregnancies subsequently complicated by intrauterine growth restriction (IUGR). We now show that the concentration of Ang-2, but not Ang-1, in maternal serum is increased during normal pregnancy, peaking at the end of the first trimester. We also demonstrate that a key source of the elevated Ang-2 levels during pregnancy is decidual endothelial cells (DECs) but not cytotrophoblasts. Secretion of Ang-2 by DECs relies on the release from intracellular stores and the synthesis of new Ang-2 protein and is regulated by serum factors at a translational level. Further studies on the role of Ang-2 during pregnancy are warranted as well as the evaluation of Ang-2 as a marker to predict adverse pregnancy outcomes.
► Ang-2, but not Ang-1, is elevated in maternal serum compared to non-pregnant serum. ► The key source of the elevated Ang-2 during pregnancy is decidual endothelial cells. ► Ang-2 release by DECs relies on intracellular stores and newly synthesized protein. ► The pregnancy-induced rise in Ang-2 in maternal sera is attenuated in IUGR.</description><subject>Adult</subject><subject>Angiopoietin-1 - blood</subject><subject>Angiopoietin-2 - blood</subject><subject>Decidua - pathology</subject><subject>Enzyme-Linked Immunosorbent Assay - methods</subject><subject>Female</subject><subject>Fetal Growth Retardation - blood</subject><subject>Gene Expression Regulation</subject><subject>Humans</subject><subject>Immunoglobulin G - metabolism</subject><subject>Keratin-7 - biosynthesis</subject><subject>Placenta - metabolism</subject><subject>Platelet Endothelial Cell Adhesion Molecule-1 - biosynthesis</subject><subject>Pregnancy</subject><subject>Pregnancy Outcome</subject><subject>Pregnancy Trimester, First</subject><subject>Trophoblasts - cytology</subject><issn>0026-2862</issn><issn>1095-9319</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LxDAQhoMoun78AC_So5fWSWLSBkGQxS8QPKjnkKbTNcs2qUmr-O_tsqtHT3OY532ZeQg5pVBQoPJiWXSfsWBAWQFVAcB3yIyCErniVO2SGQCTOaskOyCHKS0BKBWK7ZMDxpQSVQkzcv0SxmgxC21m_MKFPjgcnM9Z5nw2vGOWMJr19it06LNmjM4vsj7iwhtvv4_JXmtWCU-284i83d2-zh_yp-f7x_nNU2654EPe1hYE1lJJWRpZYVM2XGLblgwReU1LWiqjLstGgKyMEFAJNNPhVoEwVNb8iJxvevsYPkZMg-5csrhaGY9hTJpSxiRIXvIJpRvUxpBSxFb30XUmfmsKeq1NL_WkTa-1aaj0pG3KnG3rx7rD5i_x62kCrjYATk9-Oow6WYfeYuMi2kE3wf1T_wPK13yN</recordid><startdate>201211</startdate><enddate>201211</enddate><creator>Woolnough, C.</creator><creator>Wang, Y.</creator><creator>Kan, C.Y.</creator><creator>Morris, J.M.</creator><creator>Tasevski, V.</creator><creator>Ashton, A.W.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201211</creationdate><title>Source of angiopoietin-2 in the sera of women during pregnancy</title><author>Woolnough, C. ; Wang, Y. ; Kan, C.Y. ; Morris, J.M. ; Tasevski, V. ; Ashton, A.W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c353t-fbc05eb69667a68ed7d36eff72eee3b17179a947d5068a55085ea286c905a16b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Angiopoietin-1 - blood</topic><topic>Angiopoietin-2 - blood</topic><topic>Decidua - pathology</topic><topic>Enzyme-Linked Immunosorbent Assay - methods</topic><topic>Female</topic><topic>Fetal Growth Retardation - blood</topic><topic>Gene Expression Regulation</topic><topic>Humans</topic><topic>Immunoglobulin G - metabolism</topic><topic>Keratin-7 - biosynthesis</topic><topic>Placenta - metabolism</topic><topic>Platelet Endothelial Cell Adhesion Molecule-1 - biosynthesis</topic><topic>Pregnancy</topic><topic>Pregnancy Outcome</topic><topic>Pregnancy Trimester, First</topic><topic>Trophoblasts - cytology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Woolnough, C.</creatorcontrib><creatorcontrib>Wang, Y.</creatorcontrib><creatorcontrib>Kan, C.Y.</creatorcontrib><creatorcontrib>Morris, J.M.</creatorcontrib><creatorcontrib>Tasevski, V.</creatorcontrib><creatorcontrib>Ashton, A.W.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Microvascular research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Woolnough, C.</au><au>Wang, Y.</au><au>Kan, C.Y.</au><au>Morris, J.M.</au><au>Tasevski, V.</au><au>Ashton, A.W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Source of angiopoietin-2 in the sera of women during pregnancy</atitle><jtitle>Microvascular research</jtitle><addtitle>Microvasc Res</addtitle><date>2012-11</date><risdate>2012</risdate><volume>84</volume><issue>3</issue><spage>367</spage><epage>374</epage><pages>367-374</pages><issn>0026-2862</issn><eissn>1095-9319</eissn><abstract>Placental development requires coordinated angiogenesis regulated by multiple factors including angiopoietins. Previously we demonstrated that the concentration of angiopoietin-2 (Ang-2) in the sera of women rises markedly in pregnancy in early gestation. This increase is reduced in pregnancies subsequently complicated by intrauterine growth restriction (IUGR). We now show that the concentration of Ang-2, but not Ang-1, in maternal serum is increased during normal pregnancy, peaking at the end of the first trimester. We also demonstrate that a key source of the elevated Ang-2 levels during pregnancy is decidual endothelial cells (DECs) but not cytotrophoblasts. Secretion of Ang-2 by DECs relies on the release from intracellular stores and the synthesis of new Ang-2 protein and is regulated by serum factors at a translational level. Further studies on the role of Ang-2 during pregnancy are warranted as well as the evaluation of Ang-2 as a marker to predict adverse pregnancy outcomes.
► Ang-2, but not Ang-1, is elevated in maternal serum compared to non-pregnant serum. ► The key source of the elevated Ang-2 during pregnancy is decidual endothelial cells. ► Ang-2 release by DECs relies on intracellular stores and newly synthesized protein. ► The pregnancy-induced rise in Ang-2 in maternal sera is attenuated in IUGR.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>22995870</pmid><doi>10.1016/j.mvr.2012.08.003</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0026-2862 |
| ispartof | Microvascular research, 2012-11, Vol.84 (3), p.367-374 |
| issn | 0026-2862 1095-9319 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1122606373 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Angiopoietin-1 - blood Angiopoietin-2 - blood Decidua - pathology Enzyme-Linked Immunosorbent Assay - methods Female Fetal Growth Retardation - blood Gene Expression Regulation Humans Immunoglobulin G - metabolism Keratin-7 - biosynthesis Placenta - metabolism Platelet Endothelial Cell Adhesion Molecule-1 - biosynthesis Pregnancy Pregnancy Outcome Pregnancy Trimester, First Trophoblasts - cytology |
| title | Source of angiopoietin-2 in the sera of women during pregnancy |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-02T08%3A26%3A27IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Source%20of%20angiopoietin-2%20in%20the%20sera%20of%20women%20during%20pregnancy&rft.jtitle=Microvascular%20research&rft.au=Woolnough,%20C.&rft.date=2012-11&rft.volume=84&rft.issue=3&rft.spage=367&rft.epage=374&rft.pages=367-374&rft.issn=0026-2862&rft.eissn=1095-9319&rft_id=info:doi/10.1016/j.mvr.2012.08.003&rft_dat=%3Cproquest_cross%3E1122606373%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1122606373&rft_id=info:pmid/22995870&rft_els_id=S0026286212001525&rfr_iscdi=true |