Immunohistochemical panel for distinguishing esophageal adenocarcinoma from squamous cell carcinoma: a combination of p63, cytokeratin 5/6, MUC5AC, and anterior gradient homolog 2 allows optimal subtyping

Summary Distinguishing adenocarcinoma and squamous cell carcinoma of the esophagus is often based on morphological criteria and can be difficult in small biopsies. We analyzed commonly used immunohistochemical markers (p63, cytokeratin 5/6, cytokeratin 7, CDX2, MUC2, and MUC5AC) and 2 new markers, a...

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Veröffentlicht in:	Human pathology 2012-11, Vol.43 (11), p.1799-1807
Hauptverfasser:	DiMaio, Michael A., MD, Kwok, Shirley, BSc, Montgomery, Kelli D., BSc, Lowe, Anson W., MD, Pai, Reetesh K., MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - diagnosis Adenocarcinoma - metabolism Antigens Biological and medical sciences Biomarkers, Tumor - metabolism Biopsy Carcinoma Carcinoma, Squamous Cell - diagnosis Carcinoma, Squamous Cell - metabolism Chemotherapy Cloning Confidence intervals Cytokeratin Diagnosis, Differential Endoscopy Enzymes Esophageal cancer Esophageal Neoplasms - diagnosis Esophageal Neoplasms - metabolism Esophagogastric Junction - metabolism Esophagogastric Junction - pathology Esophagus Gastroenterology. Liver. Pancreas. Abdomen Humans Immunohistochemistry Investigative techniques, diagnostic techniques (general aspects) Keratins - metabolism Medical sciences Mucin 5AC - metabolism Pathology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Proteins - metabolism Sensitivity and Specificity Skin cancer Squamous cell carcinoma Stains & staining Stem cells Subtyping Tissue Array Analysis Transcription Factors - metabolism Tumor Suppressor Proteins - metabolism Tumors
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