Synthesis, Evaluation, and Radiolabeling of New Potent Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 2 as Potential Tracers for Positron Emission Tomography Imaging

The synthesis and in vitro and in vivo evaluation of a new series of 7-(phenylpiperidinyl)-1,2,4-triazolo[4,3-a]pyridines, which were conveniently radiolabeled with carbon-11, as potential positron emission tomography (PET) radiotracers for in vivo imaging of the allosteric binding site of the metab...

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Veröffentlicht in:Journal of medicinal chemistry 2012-10, Vol.55 (20), p.8685-8699
Hauptverfasser: Andrés, José-Ignacio, Alcázar, Jesús, Cid, José María, De Angelis, Meri, Iturrino, Laura, Langlois, Xavier, Lavreysen, Hilde, Trabanco, Andrés A, Celen, Sofie, Bormans, Guy
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Sprache:eng
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