The Risk of Parkinson Disease Associated with Urate in a Community-Based Cohort of Older Adults
Background/Aims: Studies suggest an inverse association between urate concentration and the risk of Parkinson disease (PD). We investigated this in the Cardiovascular Health Study in an elderly community-based cohort of adults. Methods: The association of baseline urate (µmol/l) and incident PD over...
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| Veröffentlicht in: | Neuroepidemiology 2011-01, Vol.36 (4), p.223-229 |
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| creator | Jain, S. Ton, T.G. Boudreau, R.M. Yang, M. Thacker, E.L. Studenski, S. Longstreth, Jr, W.T. Strotmeyer, E.S. Newman, A.B. |
| description | Background/Aims: Studies suggest an inverse association between urate concentration and the risk of Parkinson disease (PD). We investigated this in the Cardiovascular Health Study in an elderly community-based cohort of adults. Methods: The association of baseline urate (µmol/l) and incident PD over 14 years was assessed with locally weighted scatterplot smoothing (LOESS) regression from which categories of low (500 µmol/l) urate ranges were derived. Multivariate logistic regression models assessed the risk of PD for each urate range. Linear and quadratic terms were tested when modeling the association between urate and the risk of PD. Results: Women had significantly lower urate concentrations than did men [316.8 µmol/l (SD 88.0) vs. 367.4 µmol/l (SD 87.7), p < 0.0001] and in women no associations between urate and PD risk were observed. In men, LOESS curves suggested a U-shaped or threshold effect between urate and PD risk. With the middle range as reference, the risk of developing PD was significantly increased for urate 500 µmol/l (OR 1.55, 95% CI 0.72–3.32) in men. A negative linear term was significant for urate |
| doi_str_mv | 10.1159/000327748 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_1115527449</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1115527449</sourcerecordid><originalsourceid>FETCH-LOGICAL-c423t-d4a8792d93f60306e8ec0a6e79defc3af16234db93c49825afc9b4121553054f3</originalsourceid><addsrcrecordid>eNpd0c9LHDEUB_Agim7Vg3eR4Kk9TM3PmclF2G5bLQiK6Dlkkzdu3JmJJjMt_vdGdruopyTkky8v7yF0RMl3SqU6I4RwVlWi3kITKhgvCCP1NpoQJmkhuSR76EtKj4RkXKtdtMdombkoJ0jfLQDf-rTEocE3Ji59n0KPf_oEJgGephSsNwM4_M8PC3wf8x77Hhs8C1039n54KX5k6fJ5EeLwFnPdOoh46sZ2SAdopzFtgsP1uo_uf_-6m10WV9cXf2bTq8LmeofCCVNXijnFm5JwUkINlpgSKuWgsdw0tGRcuLniVqiaSdNYNReUUSk5kaLh--h8lfs0zjtwFvohmlY_Rd-Z-KKD8frjTe8X-iH81ZwyISTLAV_XATE8j5AG3flkoW1ND2FMmuZOS5abpjI9_UQfwxj7_D1dq1pSJSuR0bcVsjGkFKHZ1EKJfpua3kwt25P3xW_k_zFlcLwCSxMfIG7A-v0rOeqaZQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>898519574</pqid></control><display><type>article</type><title>The Risk of Parkinson Disease Associated with Urate in a Community-Based Cohort of Older Adults</title><source>MEDLINE</source><source>Karger Journals</source><source>Alma/SFX Local Collection</source><creator>Jain, S. ; Ton, T.G. ; Boudreau, R.M. ; Yang, M. ; Thacker, E.L. ; Studenski, S. ; Longstreth, Jr, W.T. ; Strotmeyer, E.S. ; Newman, A.B.</creator><creatorcontrib>Jain, S. ; Ton, T.G. ; Boudreau, R.M. ; Yang, M. ; Thacker, E.L. ; Studenski, S. ; Longstreth, Jr, W.T. ; Strotmeyer, E.S. ; Newman, A.B.</creatorcontrib><description>Background/Aims: Studies suggest an inverse association between urate concentration and the risk of Parkinson disease (PD). We investigated this in the Cardiovascular Health Study in an elderly community-based cohort of adults. Methods: The association of baseline urate (µmol/l) and incident PD over 14 years was assessed with locally weighted scatterplot smoothing (LOESS) regression from which categories of low (<300 µmol/l), middle (300–500 µmol/l), and high (>500 µmol/l) urate ranges were derived. Multivariate logistic regression models assessed the risk of PD for each urate range. Linear and quadratic terms were tested when modeling the association between urate and the risk of PD. Results: Women had significantly lower urate concentrations than did men [316.8 µmol/l (SD 88.0) vs. 367.4 µmol/l (SD 87.7), p < 0.0001] and in women no associations between urate and PD risk were observed. In men, LOESS curves suggested a U-shaped or threshold effect between urate and PD risk. With the middle range as reference, the risk of developing PD was significantly increased for urate <300 µmol/l (OR 1.69, 95% CI 1.03–2.78) but not for urate >500 µmol/l (OR 1.55, 95% CI 0.72–3.32) in men. A negative linear term was significant for urate <500 µmol/l, and across the entire range a convex quadratic term was significant. Conclusions: Results suggest a more complex relationship than previously reported between urate levels and the risk of PD in men. Low urate concentrations were associated with a higher PD risk and high urate concentrations were not associated with a further decrease in PD risk.</description><identifier>ISSN: 0251-5350</identifier><identifier>EISSN: 1423-0208</identifier><identifier>DOI: 10.1159/000327748</identifier><identifier>PMID: 21677446</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Aged ; California - epidemiology ; Cohort Studies ; Female ; Humans ; Male ; Maryland - epidemiology ; North Carolina - epidemiology ; Original Paper ; Parkinson Disease - blood ; Parkinson Disease - epidemiology ; Pennsylvania - epidemiology ; Prospective Studies ; Risk Factors ; Sex Distribution ; Sex Factors ; Uric Acid - blood</subject><ispartof>Neuroepidemiology, 2011-01, Vol.36 (4), p.223-229</ispartof><rights>2011 S. Karger AG, Basel</rights><rights>Copyright © 2011 S. Karger AG, Basel.</rights><rights>Copyright (c) 2011 S. Karger AG, Basel</rights><rights>Copyright © 2011 by S. Karger AG, Basel 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c423t-d4a8792d93f60306e8ec0a6e79defc3af16234db93c49825afc9b4121553054f3</citedby><cites>FETCH-LOGICAL-c423t-d4a8792d93f60306e8ec0a6e79defc3af16234db93c49825afc9b4121553054f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,2429,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21677446$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jain, S.</creatorcontrib><creatorcontrib>Ton, T.G.</creatorcontrib><creatorcontrib>Boudreau, R.M.</creatorcontrib><creatorcontrib>Yang, M.</creatorcontrib><creatorcontrib>Thacker, E.L.</creatorcontrib><creatorcontrib>Studenski, S.</creatorcontrib><creatorcontrib>Longstreth, Jr, W.T.</creatorcontrib><creatorcontrib>Strotmeyer, E.S.</creatorcontrib><creatorcontrib>Newman, A.B.</creatorcontrib><title>The Risk of Parkinson Disease Associated with Urate in a Community-Based Cohort of Older Adults</title><title>Neuroepidemiology</title><addtitle>Neuroepidemiology</addtitle><description>Background/Aims: Studies suggest an inverse association between urate concentration and the risk of Parkinson disease (PD). We investigated this in the Cardiovascular Health Study in an elderly community-based cohort of adults. Methods: The association of baseline urate (µmol/l) and incident PD over 14 years was assessed with locally weighted scatterplot smoothing (LOESS) regression from which categories of low (<300 µmol/l), middle (300–500 µmol/l), and high (>500 µmol/l) urate ranges were derived. Multivariate logistic regression models assessed the risk of PD for each urate range. Linear and quadratic terms were tested when modeling the association between urate and the risk of PD. Results: Women had significantly lower urate concentrations than did men [316.8 µmol/l (SD 88.0) vs. 367.4 µmol/l (SD 87.7), p < 0.0001] and in women no associations between urate and PD risk were observed. In men, LOESS curves suggested a U-shaped or threshold effect between urate and PD risk. With the middle range as reference, the risk of developing PD was significantly increased for urate <300 µmol/l (OR 1.69, 95% CI 1.03–2.78) but not for urate >500 µmol/l (OR 1.55, 95% CI 0.72–3.32) in men. A negative linear term was significant for urate <500 µmol/l, and across the entire range a convex quadratic term was significant. Conclusions: Results suggest a more complex relationship than previously reported between urate levels and the risk of PD in men. Low urate concentrations were associated with a higher PD risk and high urate concentrations were not associated with a further decrease in PD risk.</description><subject>Aged</subject><subject>California - epidemiology</subject><subject>Cohort Studies</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Maryland - epidemiology</subject><subject>North Carolina - epidemiology</subject><subject>Original Paper</subject><subject>Parkinson Disease - blood</subject><subject>Parkinson Disease - epidemiology</subject><subject>Pennsylvania - epidemiology</subject><subject>Prospective Studies</subject><subject>Risk Factors</subject><subject>Sex Distribution</subject><subject>Sex Factors</subject><subject>Uric Acid - blood</subject><issn>0251-5350</issn><issn>1423-0208</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpd0c9LHDEUB_Agim7Vg3eR4Kk9TM3PmclF2G5bLQiK6Dlkkzdu3JmJJjMt_vdGdruopyTkky8v7yF0RMl3SqU6I4RwVlWi3kITKhgvCCP1NpoQJmkhuSR76EtKj4RkXKtdtMdombkoJ0jfLQDf-rTEocE3Ji59n0KPf_oEJgGephSsNwM4_M8PC3wf8x77Hhs8C1039n54KX5k6fJ5EeLwFnPdOoh46sZ2SAdopzFtgsP1uo_uf_-6m10WV9cXf2bTq8LmeofCCVNXijnFm5JwUkINlpgSKuWgsdw0tGRcuLniVqiaSdNYNReUUSk5kaLh--h8lfs0zjtwFvohmlY_Rd-Z-KKD8frjTe8X-iH81ZwyISTLAV_XATE8j5AG3flkoW1ND2FMmuZOS5abpjI9_UQfwxj7_D1dq1pSJSuR0bcVsjGkFKHZ1EKJfpua3kwt25P3xW_k_zFlcLwCSxMfIG7A-v0rOeqaZQ</recordid><startdate>20110101</startdate><enddate>20110101</enddate><creator>Jain, S.</creator><creator>Ton, T.G.</creator><creator>Boudreau, R.M.</creator><creator>Yang, M.</creator><creator>Thacker, E.L.</creator><creator>Studenski, S.</creator><creator>Longstreth, Jr, W.T.</creator><creator>Strotmeyer, E.S.</creator><creator>Newman, A.B.</creator><general>S. 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Ton, T.G. ; Boudreau, R.M. ; Yang, M. ; Thacker, E.L. ; Studenski, S. ; Longstreth, Jr, W.T. ; Strotmeyer, E.S. ; Newman, A.B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c423t-d4a8792d93f60306e8ec0a6e79defc3af16234db93c49825afc9b4121553054f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Aged</topic><topic>California - epidemiology</topic><topic>Cohort Studies</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Maryland - epidemiology</topic><topic>North Carolina - epidemiology</topic><topic>Original Paper</topic><topic>Parkinson Disease - blood</topic><topic>Parkinson Disease - epidemiology</topic><topic>Pennsylvania - epidemiology</topic><topic>Prospective Studies</topic><topic>Risk Factors</topic><topic>Sex Distribution</topic><topic>Sex Factors</topic><topic>Uric Acid - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jain, S.</creatorcontrib><creatorcontrib>Ton, T.G.</creatorcontrib><creatorcontrib>Boudreau, R.M.</creatorcontrib><creatorcontrib>Yang, M.</creatorcontrib><creatorcontrib>Thacker, E.L.</creatorcontrib><creatorcontrib>Studenski, S.</creatorcontrib><creatorcontrib>Longstreth, Jr, W.T.</creatorcontrib><creatorcontrib>Strotmeyer, E.S.</creatorcontrib><creatorcontrib>Newman, A.B.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Neuroepidemiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jain, S.</au><au>Ton, T.G.</au><au>Boudreau, R.M.</au><au>Yang, M.</au><au>Thacker, E.L.</au><au>Studenski, S.</au><au>Longstreth, Jr, W.T.</au><au>Strotmeyer, E.S.</au><au>Newman, A.B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Risk of Parkinson Disease Associated with Urate in a Community-Based Cohort of Older Adults</atitle><jtitle>Neuroepidemiology</jtitle><addtitle>Neuroepidemiology</addtitle><date>2011-01-01</date><risdate>2011</risdate><volume>36</volume><issue>4</issue><spage>223</spage><epage>229</epage><pages>223-229</pages><issn>0251-5350</issn><eissn>1423-0208</eissn><abstract>Background/Aims: Studies suggest an inverse association between urate concentration and the risk of Parkinson disease (PD). We investigated this in the Cardiovascular Health Study in an elderly community-based cohort of adults. Methods: The association of baseline urate (µmol/l) and incident PD over 14 years was assessed with locally weighted scatterplot smoothing (LOESS) regression from which categories of low (<300 µmol/l), middle (300–500 µmol/l), and high (>500 µmol/l) urate ranges were derived. Multivariate logistic regression models assessed the risk of PD for each urate range. Linear and quadratic terms were tested when modeling the association between urate and the risk of PD. Results: Women had significantly lower urate concentrations than did men [316.8 µmol/l (SD 88.0) vs. 367.4 µmol/l (SD 87.7), p < 0.0001] and in women no associations between urate and PD risk were observed. In men, LOESS curves suggested a U-shaped or threshold effect between urate and PD risk. With the middle range as reference, the risk of developing PD was significantly increased for urate <300 µmol/l (OR 1.69, 95% CI 1.03–2.78) but not for urate >500 µmol/l (OR 1.55, 95% CI 0.72–3.32) in men. A negative linear term was significant for urate <500 µmol/l, and across the entire range a convex quadratic term was significant. Conclusions: Results suggest a more complex relationship than previously reported between urate levels and the risk of PD in men. Low urate concentrations were associated with a higher PD risk and high urate concentrations were not associated with a further decrease in PD risk.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>21677446</pmid><doi>10.1159/000327748</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged California - epidemiology Cohort Studies Female Humans Male Maryland - epidemiology North Carolina - epidemiology Original Paper Parkinson Disease - blood Parkinson Disease - epidemiology Pennsylvania - epidemiology Prospective Studies Risk Factors Sex Distribution Sex Factors Uric Acid - blood |
| title | The Risk of Parkinson Disease Associated with Urate in a Community-Based Cohort of Older Adults |
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