The region-specific activation of Ca2+ /calmodulin dependent protein kinase II and extracellular signal-regulated kinases in hippocampus following chronic alcohol exposure

Highlights ► Alcohol exposure, withdrawal and re-exposure induce distinct open-field behaviors. ► CA1 and DG, but not CA3 are more sensitive to alcohol-induced pERK reduction. ► Alcohol exposure induced similar patterns of pCaMKII in the CA1 and DG, but not CA3.

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Bibliographische Detailangaben
Veröffentlicht in:	Brain research bulletin 2012-12, Vol.89 (5), p.191-196
Hauptverfasser:	Wang, YunPeng, Cui, Haimin, Wang, Wei, Zhao, Bin, Lai, Jianghua
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohol dependence Alcohol Drinking - metabolism Animals CA1 Region, Hippocampal - drug effects CA1 Region, Hippocampal - enzymology Ca2+/calmodulin dependent protein kinase II Calcium-Calmodulin-Dependent Protein Kinase Type 2 - metabolism Ethanol - administration & dosage Extracellular signal-regulated kinases Hippocampus Male MAP Kinase Signaling System - drug effects MAP Kinase Signaling System - physiology Mitogen-Activated Protein Kinase 3 - physiology Mitogen-Activated Protein Kinase 6 - physiology Neurology Random Allocation Rats Rats, Sprague-Dawley
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Beschreibung
Zusammenfassung:	Highlights ► Alcohol exposure, withdrawal and re-exposure induce distinct open-field behaviors. ► CA1 and DG, but not CA3 are more sensitive to alcohol-induced pERK reduction. ► Alcohol exposure induced similar patterns of pCaMKII in the CA1 and DG, but not CA3.
ISSN:	0361-9230 1873-2747
DOI:	10.1016/j.brainresbull.2012.08.007