Adult patients with acute lymphoblastic leukemia and molecular failure display a poor prognosis and are candidates for stem cell transplantation and targeted therapies

Quantification of minimal residual disease (MRD) by real-time PCR directed to TCR and Ig gene rearrangements allows a refined evaluation of response in acute lymphoblastic leukemia (ALL). The German Multicenter Study Group for Adult ALL prospectively evaluated molecular response after induction/cons...

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Veröffentlicht in:	Blood 2012-08, Vol.120 (9), p.1868-1876
Hauptverfasser:	Gökbuget, Nicola, Kneba, Michael, Raff, Thorsten, Trautmann, Heiko, Bartram, Claus-Rainer, Arnold, Renate, Fietkau, Rainer, Freund, Mathias, Ganser, Arnold, Ludwig, Wolf-Dieter, Maschmeyer, Georg, Rieder, Harald, Schwartz, Stefan, Serve, Hubert, Thiel, Eckhard, Brüggemann, Monika, Hoelzer, Dieter
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Biological and medical sciences Combined Modality Therapy Hematologic and hematopoietic diseases Hematopoietic Stem Cell Transplantation - methods Humans Induction Chemotherapy - methods Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Medical sciences Middle Aged Neoplasm, Residual - genetics Neoplasm, Residual - therapy Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics Precursor Cell Lymphoblastic Leukemia-Lymphoma - therapy Prognosis Prospective Studies Remission Induction Survival Analysis Transplantation, Homologous Treatment Outcome Young Adult
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