Ca2+/Calmodulin-Dependent Protein Kinase II―Based Regulation of Voltage-Gated Na+ Channel in Cardiac Disease

Human gene variants affecting ion channel biophysical activity and/or membrane localization are linked to potentially fatal cardiac arrhythmias. However, the mechanism for many human arrhythmia variants remains undefined despite more than a decade of investigation. Posttranslational modulation of me...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2012-10, Vol.126 (17), p.2084-2094
Hauptverfasser:	KOVAL, Olha M, SNYDER, Jedidiah S, LAN QIAN, MITCHELL, Colleen C, BOYDEN, Penelope A, BINKLEY, Philip F, CHENGLONG LI, ANDERSON, Mark E, MOHLER, Peter J, HUND, Thomas J, WOLF, Roseanne M, PAVLOVICZ, Ryan E, GLYNN, Patric, CURRAN, Jerry, LEYMASTER, Nicholas D, WEN DUN, WRIGHT, Patrick J, CARDONA, Natalia
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arrhythmias, Cardiac - enzymology Arrhythmias, Cardiac - genetics Arrhythmias, Cardiac - metabolism Associated diseases and complications Biological and medical sciences Blood and lymphatic vessels Calcium-Calmodulin-Dependent Protein Kinase Type 2 - genetics Calcium-Calmodulin-Dependent Protein Kinase Type 2 - physiology Cardiology. Vascular system Cells, Cultured Cytoplasm - enzymology Cytoplasm - genetics Cytoplasm - metabolism Diabetes. Impaired glucose tolerance Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Dogs Endocrine pancreas. Apud cells (diseases) Endocrinopathies Genetic Variation HEK293 Cells Humans Medical sciences Mice NAV1.5 Voltage-Gated Sodium Channel - genetics NAV1.5 Voltage-Gated Sodium Channel - metabolism Phosphorylation Protein Processing, Post-Translational - genetics
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