Aquaporin 2: From its discovery to molecular structure and medical implications

This review describes the discovery of rat aquaporin 2 AQP2 as a vasopressin-regulated water channel, and subsequent isolation of human AQP2. Regarding the structure and function of AQP2, further structural analysis is necessary to understand the basic properties of individual channel function, for...

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Veröffentlicht in:	Molecular aspects of medicine 2012-10, Vol.33 (5-6), p.535-546
1. Verfasser:	Sasaki, Sei
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals AQP2 Aquaporin 2 Aquaporin 2 - chemistry Aquaporin 2 - genetics Aquaporin 2 - metabolism Diabetes Insipidus, Nephrogenic - genetics Diabetes Insipidus, Nephrogenic - metabolism Diabetes Insipidus, Nephrogenic - pathology Gene Expression Regulation Genetic Association Studies Humans Kidney collecting duct Kidney Concentrating Ability - physiology Kidney Tubules, Collecting - physiology Mice Mutation Nephrogenic diabetes insipidus Proteolysis Rats Urine concentration Vasopressin Vasopressins - metabolism Water-Electrolyte Balance - physiology
Online-Zugang:	Volltext
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