Prognostic value of cathepsin L and its inhibitor headpin in oral squamous cell carcinoma
To investigate the clinicopathological and prognostic significance of the expression of cathepsin L and its inhibitor headpin, in oral squamous cell carcinoma. Immunohistochemical studies were performed on 56 oral squamous cell carcinoma samples. We evaluated the relationship between cathepsin L and...
Gespeichert in:
| Veröffentlicht in: | Journal of laryngology and otology 2012-11, Vol.126 (11), p.1134-1137 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1137 |
|---|---|
| container_issue | 11 |
| container_start_page | 1134 |
| container_title | Journal of laryngology and otology |
| container_volume | 126 |
| creator | Nakashima, T Yasumatsu, R Masuda, M Clayman, G L Komune, S |
| description | To investigate the clinicopathological and prognostic significance of the expression of cathepsin L and its inhibitor headpin, in oral squamous cell carcinoma.
Immunohistochemical studies were performed on 56 oral squamous cell carcinoma samples. We evaluated the relationship between cathepsin L and headpin expression versus patients' clinicopathological factors and survival.
The group that was positive for cathepsin L expression tended to have positive metastatic neck lymph nodes and a poorer prognosis. Headpin expression was not related to metastasis or prognosis. Well differentiated squamous cell carcinoma had higher levels of headpin expression compared with poorly differentiated squamous cell carcinoma.
Cathepsin L expression is related to the invasive and metastatic potential of oral squamous cell carcinoma. |
| doi_str_mv | 10.1017/S0022215112001995 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1114950609</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><cupid>10_1017_S0022215112001995</cupid><sourcerecordid>2810181451</sourcerecordid><originalsourceid>FETCH-LOGICAL-c469t-b661f437918ccc9060a2ac88f9b3e8e25a4c9a1380e17ebb25c033b39614f9b03</originalsourceid><addsrcrecordid>eNp1kE9r3DAUxEVpaTZJP0AvRVACuTjRk2RZOpYl_2AhhbSHnMyzVs4q2NZGsgP99pHJJiktAYEO85t5wxDyFdgJMKhObxjjnEMJwBkDY8oPZAGV1EUpFftIFrNczPoe2U_pnmWoYvwz2ePcKKG5XJDbnzHcDSGN3tJH7CZHQ0stjhu3TX6gK4rDmvoxUT9sfOPHEOnG4XqbtfxCxI6mhwn7MCVqXddlb7R-CD0ekk8tdsl92f0H5Pf52a_lZbG6vrha_lgVViozFo1S0EpRGdDWWsMUQ45W69Y0wmnHS5TWIAjNHFSuaXhpmRCNMApkZpg4IMfPudsYHiaXxrr3aa6Cg8utagCQpsy5JqPf_0HvwxSH3C5TEowWSs8UPFM2hpSia-tt9D3GPzWwet69_m_37Pm2S56a3q1fHS9DZ-BoB2Cy2LURB-vTG6dKZThUmRO749g30a_v3F8d3z3_BCPrmBE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1141983689</pqid></control><display><type>article</type><title>Prognostic value of cathepsin L and its inhibitor headpin in oral squamous cell carcinoma</title><source>Cambridge Journals Online</source><source>MEDLINE</source><creator>Nakashima, T ; Yasumatsu, R ; Masuda, M ; Clayman, G L ; Komune, S</creator><creatorcontrib>Nakashima, T ; Yasumatsu, R ; Masuda, M ; Clayman, G L ; Komune, S</creatorcontrib><description>To investigate the clinicopathological and prognostic significance of the expression of cathepsin L and its inhibitor headpin, in oral squamous cell carcinoma.
Immunohistochemical studies were performed on 56 oral squamous cell carcinoma samples. We evaluated the relationship between cathepsin L and headpin expression versus patients' clinicopathological factors and survival.
The group that was positive for cathepsin L expression tended to have positive metastatic neck lymph nodes and a poorer prognosis. Headpin expression was not related to metastasis or prognosis. Well differentiated squamous cell carcinoma had higher levels of headpin expression compared with poorly differentiated squamous cell carcinoma.
Cathepsin L expression is related to the invasive and metastatic potential of oral squamous cell carcinoma.</description><identifier>ISSN: 0022-2151</identifier><identifier>EISSN: 1748-5460</identifier><identifier>DOI: 10.1017/S0022215112001995</identifier><identifier>PMID: 22963824</identifier><identifier>CODEN: JLOTAX</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Antibodies ; Biological and medical sciences ; Biomarkers, Tumor - metabolism ; Cancer ; Carcinoma, Squamous Cell - metabolism ; Carcinoma, Squamous Cell - mortality ; Carcinoma, Squamous Cell - pathology ; Cathepsin L - metabolism ; Dermatology ; Head and Neck Neoplasms - metabolism ; Head and Neck Neoplasms - mortality ; Head and Neck Neoplasms - pathology ; Humans ; Immunohistochemistry ; Lymphatic Metastasis ; Lymphatic system ; Main Articles ; Medical prognosis ; Medical sciences ; Metastasis ; Mouth Neoplasms - metabolism ; Mouth Neoplasms - mortality ; Mouth Neoplasms - pathology ; Otorhinolaryngology. Stomatology ; Patients ; Prognosis ; Serpins - metabolism ; Squamous Cell Carcinoma of Head and Neck ; Survival Analysis ; Tongue ; Tumors ; Tumors of the skin and soft tissue. Premalignant lesions ; Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><ispartof>Journal of laryngology and otology, 2012-11, Vol.126 (11), p.1134-1137</ispartof><rights>Copyright © JLO (1984) Limited 2012</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c469t-b661f437918ccc9060a2ac88f9b3e8e25a4c9a1380e17ebb25c033b39614f9b03</citedby><cites>FETCH-LOGICAL-c469t-b661f437918ccc9060a2ac88f9b3e8e25a4c9a1380e17ebb25c033b39614f9b03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S0022215112001995/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>164,314,776,780,27901,27902,55603</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26569217$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22963824$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nakashima, T</creatorcontrib><creatorcontrib>Yasumatsu, R</creatorcontrib><creatorcontrib>Masuda, M</creatorcontrib><creatorcontrib>Clayman, G L</creatorcontrib><creatorcontrib>Komune, S</creatorcontrib><title>Prognostic value of cathepsin L and its inhibitor headpin in oral squamous cell carcinoma</title><title>Journal of laryngology and otology</title><addtitle>J. Laryngol. Otol</addtitle><description>To investigate the clinicopathological and prognostic significance of the expression of cathepsin L and its inhibitor headpin, in oral squamous cell carcinoma.
Immunohistochemical studies were performed on 56 oral squamous cell carcinoma samples. We evaluated the relationship between cathepsin L and headpin expression versus patients' clinicopathological factors and survival.
The group that was positive for cathepsin L expression tended to have positive metastatic neck lymph nodes and a poorer prognosis. Headpin expression was not related to metastasis or prognosis. Well differentiated squamous cell carcinoma had higher levels of headpin expression compared with poorly differentiated squamous cell carcinoma.
Cathepsin L expression is related to the invasive and metastatic potential of oral squamous cell carcinoma.</description><subject>Antibodies</subject><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Cancer</subject><subject>Carcinoma, Squamous Cell - metabolism</subject><subject>Carcinoma, Squamous Cell - mortality</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Cathepsin L - metabolism</subject><subject>Dermatology</subject><subject>Head and Neck Neoplasms - metabolism</subject><subject>Head and Neck Neoplasms - mortality</subject><subject>Head and Neck Neoplasms - pathology</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Lymphatic Metastasis</subject><subject>Lymphatic system</subject><subject>Main Articles</subject><subject>Medical prognosis</subject><subject>Medical sciences</subject><subject>Metastasis</subject><subject>Mouth Neoplasms - metabolism</subject><subject>Mouth Neoplasms - mortality</subject><subject>Mouth Neoplasms - pathology</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Patients</subject><subject>Prognosis</subject><subject>Serpins - metabolism</subject><subject>Squamous Cell Carcinoma of Head and Neck</subject><subject>Survival Analysis</subject><subject>Tongue</subject><subject>Tumors</subject><subject>Tumors of the skin and soft tissue. Premalignant lesions</subject><subject>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><issn>0022-2151</issn><issn>1748-5460</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kE9r3DAUxEVpaTZJP0AvRVACuTjRk2RZOpYl_2AhhbSHnMyzVs4q2NZGsgP99pHJJiktAYEO85t5wxDyFdgJMKhObxjjnEMJwBkDY8oPZAGV1EUpFftIFrNczPoe2U_pnmWoYvwz2ePcKKG5XJDbnzHcDSGN3tJH7CZHQ0stjhu3TX6gK4rDmvoxUT9sfOPHEOnG4XqbtfxCxI6mhwn7MCVqXddlb7R-CD0ekk8tdsl92f0H5Pf52a_lZbG6vrha_lgVViozFo1S0EpRGdDWWsMUQ45W69Y0wmnHS5TWIAjNHFSuaXhpmRCNMApkZpg4IMfPudsYHiaXxrr3aa6Cg8utagCQpsy5JqPf_0HvwxSH3C5TEowWSs8UPFM2hpSia-tt9D3GPzWwet69_m_37Pm2S56a3q1fHS9DZ-BoB2Cy2LURB-vTG6dKZThUmRO749g30a_v3F8d3z3_BCPrmBE</recordid><startdate>20121101</startdate><enddate>20121101</enddate><creator>Nakashima, T</creator><creator>Yasumatsu, R</creator><creator>Masuda, M</creator><creator>Clayman, G L</creator><creator>Komune, S</creator><general>Cambridge University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>S0X</scope><scope>7X8</scope></search><sort><creationdate>20121101</creationdate><title>Prognostic value of cathepsin L and its inhibitor headpin in oral squamous cell carcinoma</title><author>Nakashima, T ; Yasumatsu, R ; Masuda, M ; Clayman, G L ; Komune, S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c469t-b661f437918ccc9060a2ac88f9b3e8e25a4c9a1380e17ebb25c033b39614f9b03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Antibodies</topic><topic>Biological and medical sciences</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Cancer</topic><topic>Carcinoma, Squamous Cell - metabolism</topic><topic>Carcinoma, Squamous Cell - mortality</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Cathepsin L - metabolism</topic><topic>Dermatology</topic><topic>Head and Neck Neoplasms - metabolism</topic><topic>Head and Neck Neoplasms - mortality</topic><topic>Head and Neck Neoplasms - pathology</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Lymphatic Metastasis</topic><topic>Lymphatic system</topic><topic>Main Articles</topic><topic>Medical prognosis</topic><topic>Medical sciences</topic><topic>Metastasis</topic><topic>Mouth Neoplasms - metabolism</topic><topic>Mouth Neoplasms - mortality</topic><topic>Mouth Neoplasms - pathology</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Patients</topic><topic>Prognosis</topic><topic>Serpins - metabolism</topic><topic>Squamous Cell Carcinoma of Head and Neck</topic><topic>Survival Analysis</topic><topic>Tongue</topic><topic>Tumors</topic><topic>Tumors of the skin and soft tissue. Premalignant lesions</topic><topic>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nakashima, T</creatorcontrib><creatorcontrib>Yasumatsu, R</creatorcontrib><creatorcontrib>Masuda, M</creatorcontrib><creatorcontrib>Clayman, G L</creatorcontrib><creatorcontrib>Komune, S</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database (ProQuest)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection (Proquest)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Science Journals</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of laryngology and otology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nakashima, T</au><au>Yasumatsu, R</au><au>Masuda, M</au><au>Clayman, G L</au><au>Komune, S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic value of cathepsin L and its inhibitor headpin in oral squamous cell carcinoma</atitle><jtitle>Journal of laryngology and otology</jtitle><addtitle>J. Laryngol. Otol</addtitle><date>2012-11-01</date><risdate>2012</risdate><volume>126</volume><issue>11</issue><spage>1134</spage><epage>1137</epage><pages>1134-1137</pages><issn>0022-2151</issn><eissn>1748-5460</eissn><coden>JLOTAX</coden><abstract>To investigate the clinicopathological and prognostic significance of the expression of cathepsin L and its inhibitor headpin, in oral squamous cell carcinoma.
Immunohistochemical studies were performed on 56 oral squamous cell carcinoma samples. We evaluated the relationship between cathepsin L and headpin expression versus patients' clinicopathological factors and survival.
The group that was positive for cathepsin L expression tended to have positive metastatic neck lymph nodes and a poorer prognosis. Headpin expression was not related to metastasis or prognosis. Well differentiated squamous cell carcinoma had higher levels of headpin expression compared with poorly differentiated squamous cell carcinoma.
Cathepsin L expression is related to the invasive and metastatic potential of oral squamous cell carcinoma.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>22963824</pmid><doi>10.1017/S0022215112001995</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-2151 |
| ispartof | Journal of laryngology and otology, 2012-11, Vol.126 (11), p.1134-1137 |
| issn | 0022-2151 1748-5460 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1114950609 |
| source | Cambridge Journals Online; MEDLINE |
| subjects | Antibodies Biological and medical sciences Biomarkers, Tumor - metabolism Cancer Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - mortality Carcinoma, Squamous Cell - pathology Cathepsin L - metabolism Dermatology Head and Neck Neoplasms - metabolism Head and Neck Neoplasms - mortality Head and Neck Neoplasms - pathology Humans Immunohistochemistry Lymphatic Metastasis Lymphatic system Main Articles Medical prognosis Medical sciences Metastasis Mouth Neoplasms - metabolism Mouth Neoplasms - mortality Mouth Neoplasms - pathology Otorhinolaryngology. Stomatology Patients Prognosis Serpins - metabolism Squamous Cell Carcinoma of Head and Neck Survival Analysis Tongue Tumors Tumors of the skin and soft tissue. Premalignant lesions Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology |
| title | Prognostic value of cathepsin L and its inhibitor headpin in oral squamous cell carcinoma |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-29T08%3A11%3A44IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Prognostic%20value%20of%20cathepsin%20L%20and%20its%20inhibitor%20headpin%20in%20oral%20squamous%20cell%20carcinoma&rft.jtitle=Journal%20of%20laryngology%20and%20otology&rft.au=Nakashima,%20T&rft.date=2012-11-01&rft.volume=126&rft.issue=11&rft.spage=1134&rft.epage=1137&rft.pages=1134-1137&rft.issn=0022-2151&rft.eissn=1748-5460&rft.coden=JLOTAX&rft_id=info:doi/10.1017/S0022215112001995&rft_dat=%3Cproquest_cross%3E2810181451%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1141983689&rft_id=info:pmid/22963824&rft_cupid=10_1017_S0022215112001995&rfr_iscdi=true |