Protective effect of ethyl pyruvate on liver injury in streptozotocin-induced diabetic rats
Diabetes Mellitus, leading to an increase in oxidative stress, can cause liver damage. Our aim was to investigate the antioxidant effects of Ethyl Pyruvate (EP) on the liver tissue in diabetic rats. Thirty-two Wistar albino rats were separated into four equal groups. Groups were assigned as follows:...
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Veröffentlicht in: | Acta gastro-enterologica belgica 2012-09, Vol.75 (3), p.336-341 |
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description | Diabetes Mellitus, leading to an increase in oxidative stress, can cause liver damage. Our aim was to investigate the antioxidant effects of Ethyl Pyruvate (EP) on the liver tissue in diabetic rats.
Thirty-two Wistar albino rats were separated into four equal groups. Groups were assigned as follows: (1) Non-diabetic group; (2) EP-treated non-diabetic group; (3) diabetic group; and (4) EP-treated diabetic group. In order to induce diabetes mellitus, 45 mg/kg b.w. streptozotocin was administered intraperitoneally to the rats in groups 3 and 4. On the 3rd day, blood glucose was assessed. Rats with blood glucose levels higher than 300 mg/dl were considered to be diabetic. The EP solution was administered intraperitoneally at a dose of 50 mg/kg b.w. twice daily for 14 days to the rats in groups 2 and 4. The other rats were simultaneously given the same amount of Ringer's lactate solution intraperitoneally. Liver tissue was obtained for malondialdehyde (MDA) analyses and histopathological examination.
In group 4, Total Antioxidant Status (TOS) and MDA levels were significantly lower as compared to group 3. Also, morphological abnormalities occurred in group 3 when compared with non-diabetic groups (groups 1 and 2), whereas the disorders resulting from diabetes improved significantly in group 4.
These findings show that EP has protective effects against diabetes-induced liver injury. |
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Thirty-two Wistar albino rats were separated into four equal groups. Groups were assigned as follows: (1) Non-diabetic group; (2) EP-treated non-diabetic group; (3) diabetic group; and (4) EP-treated diabetic group. In order to induce diabetes mellitus, 45 mg/kg b.w. streptozotocin was administered intraperitoneally to the rats in groups 3 and 4. On the 3rd day, blood glucose was assessed. Rats with blood glucose levels higher than 300 mg/dl were considered to be diabetic. The EP solution was administered intraperitoneally at a dose of 50 mg/kg b.w. twice daily for 14 days to the rats in groups 2 and 4. The other rats were simultaneously given the same amount of Ringer's lactate solution intraperitoneally. Liver tissue was obtained for malondialdehyde (MDA) analyses and histopathological examination.
In group 4, Total Antioxidant Status (TOS) and MDA levels were significantly lower as compared to group 3. Also, morphological abnormalities occurred in group 3 when compared with non-diabetic groups (groups 1 and 2), whereas the disorders resulting from diabetes improved significantly in group 4.
These findings show that EP has protective effects against diabetes-induced liver injury.</description><identifier>ISSN: 1784-3227</identifier><identifier>PMID: 23082705</identifier><language>eng</language><publisher>Brussels: Société Royale Belge de Gastro-Entérologie</publisher><subject>Animals ; Biological and medical sciences ; Diabetes Mellitus, Experimental - complications ; Diabetes. Impaired glucose tolerance ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Gastroenterology. Liver. Pancreas. Abdomen ; Hepatocytes - pathology ; Hepatocytes - ultrastructure ; Liver - ultrastructure ; Male ; Malondialdehyde - analysis ; Medical sciences ; Oxidative Stress - drug effects ; Pyruvates - pharmacology ; Pyruvates - therapeutic use ; Rats ; Rats, Wistar ; Streptozocin</subject><ispartof>Acta gastro-enterologica belgica, 2012-09, Vol.75 (3), p.336-341</ispartof><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26389458$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23082705$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>AKKOC, H</creatorcontrib><creatorcontrib>KELLE, I</creatorcontrib><creatorcontrib>TUNIK, S</creatorcontrib><creatorcontrib>BAHCECI, S</creatorcontrib><creatorcontrib>SENCAR, L</creatorcontrib><creatorcontrib>AYAZ, E</creatorcontrib><creatorcontrib>NERGIZ, Y</creatorcontrib><creatorcontrib>ERDINC, L</creatorcontrib><creatorcontrib>ERDINC, M</creatorcontrib><title>Protective effect of ethyl pyruvate on liver injury in streptozotocin-induced diabetic rats</title><title>Acta gastro-enterologica belgica</title><addtitle>Acta Gastroenterol Belg</addtitle><description>Diabetes Mellitus, leading to an increase in oxidative stress, can cause liver damage. Our aim was to investigate the antioxidant effects of Ethyl Pyruvate (EP) on the liver tissue in diabetic rats.
Thirty-two Wistar albino rats were separated into four equal groups. Groups were assigned as follows: (1) Non-diabetic group; (2) EP-treated non-diabetic group; (3) diabetic group; and (4) EP-treated diabetic group. In order to induce diabetes mellitus, 45 mg/kg b.w. streptozotocin was administered intraperitoneally to the rats in groups 3 and 4. On the 3rd day, blood glucose was assessed. Rats with blood glucose levels higher than 300 mg/dl were considered to be diabetic. The EP solution was administered intraperitoneally at a dose of 50 mg/kg b.w. twice daily for 14 days to the rats in groups 2 and 4. The other rats were simultaneously given the same amount of Ringer's lactate solution intraperitoneally. Liver tissue was obtained for malondialdehyde (MDA) analyses and histopathological examination.
In group 4, Total Antioxidant Status (TOS) and MDA levels were significantly lower as compared to group 3. Also, morphological abnormalities occurred in group 3 when compared with non-diabetic groups (groups 1 and 2), whereas the disorders resulting from diabetes improved significantly in group 4.
These findings show that EP has protective effects against diabetes-induced liver injury.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Diabetes Mellitus, Experimental - complications</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Hepatocytes - pathology</subject><subject>Hepatocytes - ultrastructure</subject><subject>Liver - ultrastructure</subject><subject>Male</subject><subject>Malondialdehyde - analysis</subject><subject>Medical sciences</subject><subject>Oxidative Stress - drug effects</subject><subject>Pyruvates - pharmacology</subject><subject>Pyruvates - therapeutic use</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Streptozocin</subject><issn>1784-3227</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpF0E1LxDAQBuAcFHdZ9y9ILoKXQiZfbY-y-AWCHvTkoaTpBLN0m5qkC_XXW3DFubxzeHhh5oysoaxkITgvV2Sb0p4tU0tgnF2QFRes4iVTa_LxGkNGm_0RKTq3bDQ4ivlz7uk4x-loMtIw0H4BkfphP8V5CZpyxDGH75CD9UPhh26y2NHOmxaztzSanC7JuTN9wu0pN-T9_u5t91g8vzw87W6fixFKyIWSUNcCWy0sOK5BttpAKY10ygBTtUReOa1cyZi0oCsOqI1SsjWKadBcbMjNb-8Yw9eEKTcHnyz2vRkwTKkBALkcy6Ra6NWJTu0Bu2aM_mDi3Pw9ZAHXJ2CSNb2LZrA-_TstqlqqSvwAXGFozA</recordid><startdate>20120901</startdate><enddate>20120901</enddate><creator>AKKOC, H</creator><creator>KELLE, I</creator><creator>TUNIK, S</creator><creator>BAHCECI, S</creator><creator>SENCAR, L</creator><creator>AYAZ, E</creator><creator>NERGIZ, Y</creator><creator>ERDINC, L</creator><creator>ERDINC, M</creator><general>Société Royale Belge de Gastro-Entérologie</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20120901</creationdate><title>Protective effect of ethyl pyruvate on liver injury in streptozotocin-induced diabetic rats</title><author>AKKOC, H ; KELLE, I ; TUNIK, S ; BAHCECI, S ; SENCAR, L ; AYAZ, E ; NERGIZ, Y ; ERDINC, L ; ERDINC, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p171t-541993eb63c1f2614b6a174a4f5a10594e28f65f7004c16821e6a554ba5061623</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Diabetes Mellitus, Experimental - complications</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Etiopathogenesis. Screening. Investigations. Target tissue resistance</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Hepatocytes - pathology</topic><topic>Hepatocytes - ultrastructure</topic><topic>Liver - ultrastructure</topic><topic>Male</topic><topic>Malondialdehyde - analysis</topic><topic>Medical sciences</topic><topic>Oxidative Stress - drug effects</topic><topic>Pyruvates - pharmacology</topic><topic>Pyruvates - therapeutic use</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Streptozocin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>AKKOC, H</creatorcontrib><creatorcontrib>KELLE, I</creatorcontrib><creatorcontrib>TUNIK, S</creatorcontrib><creatorcontrib>BAHCECI, S</creatorcontrib><creatorcontrib>SENCAR, L</creatorcontrib><creatorcontrib>AYAZ, E</creatorcontrib><creatorcontrib>NERGIZ, Y</creatorcontrib><creatorcontrib>ERDINC, L</creatorcontrib><creatorcontrib>ERDINC, M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Acta gastro-enterologica belgica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>AKKOC, H</au><au>KELLE, I</au><au>TUNIK, S</au><au>BAHCECI, S</au><au>SENCAR, L</au><au>AYAZ, E</au><au>NERGIZ, Y</au><au>ERDINC, L</au><au>ERDINC, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protective effect of ethyl pyruvate on liver injury in streptozotocin-induced diabetic rats</atitle><jtitle>Acta gastro-enterologica belgica</jtitle><addtitle>Acta Gastroenterol Belg</addtitle><date>2012-09-01</date><risdate>2012</risdate><volume>75</volume><issue>3</issue><spage>336</spage><epage>341</epage><pages>336-341</pages><issn>1784-3227</issn><abstract>Diabetes Mellitus, leading to an increase in oxidative stress, can cause liver damage. Our aim was to investigate the antioxidant effects of Ethyl Pyruvate (EP) on the liver tissue in diabetic rats.
Thirty-two Wistar albino rats were separated into four equal groups. Groups were assigned as follows: (1) Non-diabetic group; (2) EP-treated non-diabetic group; (3) diabetic group; and (4) EP-treated diabetic group. In order to induce diabetes mellitus, 45 mg/kg b.w. streptozotocin was administered intraperitoneally to the rats in groups 3 and 4. On the 3rd day, blood glucose was assessed. Rats with blood glucose levels higher than 300 mg/dl were considered to be diabetic. The EP solution was administered intraperitoneally at a dose of 50 mg/kg b.w. twice daily for 14 days to the rats in groups 2 and 4. The other rats were simultaneously given the same amount of Ringer's lactate solution intraperitoneally. Liver tissue was obtained for malondialdehyde (MDA) analyses and histopathological examination.
In group 4, Total Antioxidant Status (TOS) and MDA levels were significantly lower as compared to group 3. Also, morphological abnormalities occurred in group 3 when compared with non-diabetic groups (groups 1 and 2), whereas the disorders resulting from diabetes improved significantly in group 4.
These findings show that EP has protective effects against diabetes-induced liver injury.</abstract><cop>Brussels</cop><pub>Société Royale Belge de Gastro-Entérologie</pub><pmid>23082705</pmid><tpages>6</tpages></addata></record> |
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subjects | Animals Biological and medical sciences Diabetes Mellitus, Experimental - complications Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Gastroenterology. Liver. Pancreas. Abdomen Hepatocytes - pathology Hepatocytes - ultrastructure Liver - ultrastructure Male Malondialdehyde - analysis Medical sciences Oxidative Stress - drug effects Pyruvates - pharmacology Pyruvates - therapeutic use Rats Rats, Wistar Streptozocin |
title | Protective effect of ethyl pyruvate on liver injury in streptozotocin-induced diabetic rats |
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