Protective effect of ethyl pyruvate on liver injury in streptozotocin-induced diabetic rats

Diabetes Mellitus, leading to an increase in oxidative stress, can cause liver damage. Our aim was to investigate the antioxidant effects of Ethyl Pyruvate (EP) on the liver tissue in diabetic rats. Thirty-two Wistar albino rats were separated into four equal groups. Groups were assigned as follows:...

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Veröffentlicht in:Acta gastro-enterologica belgica 2012-09, Vol.75 (3), p.336-341
Hauptverfasser: AKKOC, H, KELLE, I, TUNIK, S, BAHCECI, S, SENCAR, L, AYAZ, E, NERGIZ, Y, ERDINC, L, ERDINC, M
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container_title Acta gastro-enterologica belgica
container_volume 75
creator AKKOC, H
KELLE, I
TUNIK, S
BAHCECI, S
SENCAR, L
AYAZ, E
NERGIZ, Y
ERDINC, L
ERDINC, M
description Diabetes Mellitus, leading to an increase in oxidative stress, can cause liver damage. Our aim was to investigate the antioxidant effects of Ethyl Pyruvate (EP) on the liver tissue in diabetic rats. Thirty-two Wistar albino rats were separated into four equal groups. Groups were assigned as follows: (1) Non-diabetic group; (2) EP-treated non-diabetic group; (3) diabetic group; and (4) EP-treated diabetic group. In order to induce diabetes mellitus, 45 mg/kg b.w. streptozotocin was administered intraperitoneally to the rats in groups 3 and 4. On the 3rd day, blood glucose was assessed. Rats with blood glucose levels higher than 300 mg/dl were considered to be diabetic. The EP solution was administered intraperitoneally at a dose of 50 mg/kg b.w. twice daily for 14 days to the rats in groups 2 and 4. The other rats were simultaneously given the same amount of Ringer's lactate solution intraperitoneally. Liver tissue was obtained for malondialdehyde (MDA) analyses and histopathological examination. In group 4, Total Antioxidant Status (TOS) and MDA levels were significantly lower as compared to group 3. Also, morphological abnormalities occurred in group 3 when compared with non-diabetic groups (groups 1 and 2), whereas the disorders resulting from diabetes improved significantly in group 4. These findings show that EP has protective effects against diabetes-induced liver injury.
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Our aim was to investigate the antioxidant effects of Ethyl Pyruvate (EP) on the liver tissue in diabetic rats. Thirty-two Wistar albino rats were separated into four equal groups. Groups were assigned as follows: (1) Non-diabetic group; (2) EP-treated non-diabetic group; (3) diabetic group; and (4) EP-treated diabetic group. In order to induce diabetes mellitus, 45 mg/kg b.w. streptozotocin was administered intraperitoneally to the rats in groups 3 and 4. On the 3rd day, blood glucose was assessed. Rats with blood glucose levels higher than 300 mg/dl were considered to be diabetic. The EP solution was administered intraperitoneally at a dose of 50 mg/kg b.w. twice daily for 14 days to the rats in groups 2 and 4. The other rats were simultaneously given the same amount of Ringer's lactate solution intraperitoneally. Liver tissue was obtained for malondialdehyde (MDA) analyses and histopathological examination. In group 4, Total Antioxidant Status (TOS) and MDA levels were significantly lower as compared to group 3. Also, morphological abnormalities occurred in group 3 when compared with non-diabetic groups (groups 1 and 2), whereas the disorders resulting from diabetes improved significantly in group 4. These findings show that EP has protective effects against diabetes-induced liver injury.</description><identifier>ISSN: 1784-3227</identifier><identifier>PMID: 23082705</identifier><language>eng</language><publisher>Brussels: Société Royale Belge de Gastro-Entérologie</publisher><subject>Animals ; Biological and medical sciences ; Diabetes Mellitus, Experimental - complications ; Diabetes. Impaired glucose tolerance ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Gastroenterology. Liver. Pancreas. 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Impaired glucose tolerance</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Etiopathogenesis. Screening. Investigations. Target tissue resistance</topic><topic>Gastroenterology. Liver. Pancreas. 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In group 4, Total Antioxidant Status (TOS) and MDA levels were significantly lower as compared to group 3. Also, morphological abnormalities occurred in group 3 when compared with non-diabetic groups (groups 1 and 2), whereas the disorders resulting from diabetes improved significantly in group 4. These findings show that EP has protective effects against diabetes-induced liver injury.</abstract><cop>Brussels</cop><pub>Société Royale Belge de Gastro-Entérologie</pub><pmid>23082705</pmid><tpages>6</tpages></addata></record>
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subjects Animals
Biological and medical sciences
Diabetes Mellitus, Experimental - complications
Diabetes. Impaired glucose tolerance
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Gastroenterology. Liver. Pancreas. Abdomen
Hepatocytes - pathology
Hepatocytes - ultrastructure
Liver - ultrastructure
Male
Malondialdehyde - analysis
Medical sciences
Oxidative Stress - drug effects
Pyruvates - pharmacology
Pyruvates - therapeutic use
Rats
Rats, Wistar
Streptozocin
title Protective effect of ethyl pyruvate on liver injury in streptozotocin-induced diabetic rats
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