Hair growth-promoting effect of Aconiti Ciliare Tuber extract mediated by the activation of Wnt/β-catenin signaling
The activation of Wnt/β-catenin signaling pathway plays an important role in hair follicle morphogenesis by stimulating bulge stem cells. This study was to obtain the activator of Wnt/β-catenin signaling pathway from natural products and to determine whether this activator can induce anagen hair gro...
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| Veröffentlicht in: | Life sciences (1973) 2012-11, Vol.91 (19-20), p.935-943 |
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| container_title | Life sciences (1973) |
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| creator | Park, Phil-June Moon, Byoung-San Lee, Soung-Hoon Kim, Su-Na Kim, Ah-Reum Kim, Hyung-Jun Park, Won-Seok Choi, Kang-Yell Cho, Eun-Gyung Lee, Tae Ryong |
| description | The activation of Wnt/β-catenin signaling pathway plays an important role in hair follicle morphogenesis by stimulating bulge stem cells. This study was to obtain the activator of Wnt/β-catenin signaling pathway from natural products and to determine whether this activator can induce anagen hair growth in mice.
To identify materials that activate Wnt/β-catenin signaling pathway, 800 natural product extracts were screened using pTOPFlash assay and neural progenitor cell (NPC) differentiation assay. A selected extract was further tested for its effects on alkaline phosphatase (ALP) activity in human immortalized dermal papilla cell (iDPC) and the proliferation in iDPC and immortalized rat vibrissa DPC (RvDP). Finally, hair growth-promoting effects were evaluated in the dorsal skin of C57BL/6 mice.
Aconiti Ciliare Tuber (ACT) extract was one of the most active materials in both pTOPFlash and NPC differentiation assays. It promoted the differentiation of NPC cells even under proliferation-stimulating conditions (basic fibroblast growth factor: bFGF). It also increased ALP activity and proliferation of iDPC in dose-dependent manners, and it stimulated the induction of the anagen hair growth in C57BL/6 mice. These results suggest that ACT extract activates the Wnt/β-catenin signaling pathway by enhancing β-catenin transcription and has the potential to promote the induction of hair growth via activation of the stem cell activity of the dermal papilla cells.
This is the first report indicating benefits of ACT extract in hair loss prevention by triggering the activation of Wnt/β-catenin signaling pathway and induction of the anagen hair growth in mice. |
| doi_str_mv | 10.1016/j.lfs.2012.09.008 |
| format | Article |
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To identify materials that activate Wnt/β-catenin signaling pathway, 800 natural product extracts were screened using pTOPFlash assay and neural progenitor cell (NPC) differentiation assay. A selected extract was further tested for its effects on alkaline phosphatase (ALP) activity in human immortalized dermal papilla cell (iDPC) and the proliferation in iDPC and immortalized rat vibrissa DPC (RvDP). Finally, hair growth-promoting effects were evaluated in the dorsal skin of C57BL/6 mice.
Aconiti Ciliare Tuber (ACT) extract was one of the most active materials in both pTOPFlash and NPC differentiation assays. It promoted the differentiation of NPC cells even under proliferation-stimulating conditions (basic fibroblast growth factor: bFGF). It also increased ALP activity and proliferation of iDPC in dose-dependent manners, and it stimulated the induction of the anagen hair growth in C57BL/6 mice. These results suggest that ACT extract activates the Wnt/β-catenin signaling pathway by enhancing β-catenin transcription and has the potential to promote the induction of hair growth via activation of the stem cell activity of the dermal papilla cells.
This is the first report indicating benefits of ACT extract in hair loss prevention by triggering the activation of Wnt/β-catenin signaling pathway and induction of the anagen hair growth in mice.</description><identifier>ISSN: 0024-3205</identifier><identifier>EISSN: 1879-0631</identifier><identifier>DOI: 10.1016/j.lfs.2012.09.008</identifier><identifier>PMID: 23000887</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Aconiti Ciliare Tuber (ACT) extract ; Aconitum - chemistry ; Alkaline phosphatase (ALP) ; Alkaline Phosphatase - metabolism ; Animals ; beta Catenin - metabolism ; Cell Differentiation - drug effects ; Cell Proliferation - drug effects ; Dose-Response Relationship, Drug ; Hair - drug effects ; Hair - growth & development ; Hair growth ; HEK293 Cells ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Plant Extracts - administration & dosage ; Plant Extracts - pharmacology ; Rats ; Rats, Sprague-Dawley ; Stem Cells - metabolism ; Transcription, Genetic - drug effects ; Wnt Signaling Pathway - drug effects ; Wnt/β-catenin signaling pathway</subject><ispartof>Life sciences (1973), 2012-11, Vol.91 (19-20), p.935-943</ispartof><rights>2012 Elsevier Inc.</rights><rights>Copyright © 2012 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c353t-f54256fa86f35708052bc5a78851387910425c3fddc9809249a99b18b942277c3</citedby><cites>FETCH-LOGICAL-c353t-f54256fa86f35708052bc5a78851387910425c3fddc9809249a99b18b942277c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.lfs.2012.09.008$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23000887$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Park, Phil-June</creatorcontrib><creatorcontrib>Moon, Byoung-San</creatorcontrib><creatorcontrib>Lee, Soung-Hoon</creatorcontrib><creatorcontrib>Kim, Su-Na</creatorcontrib><creatorcontrib>Kim, Ah-Reum</creatorcontrib><creatorcontrib>Kim, Hyung-Jun</creatorcontrib><creatorcontrib>Park, Won-Seok</creatorcontrib><creatorcontrib>Choi, Kang-Yell</creatorcontrib><creatorcontrib>Cho, Eun-Gyung</creatorcontrib><creatorcontrib>Lee, Tae Ryong</creatorcontrib><title>Hair growth-promoting effect of Aconiti Ciliare Tuber extract mediated by the activation of Wnt/β-catenin signaling</title><title>Life sciences (1973)</title><addtitle>Life Sci</addtitle><description>The activation of Wnt/β-catenin signaling pathway plays an important role in hair follicle morphogenesis by stimulating bulge stem cells. This study was to obtain the activator of Wnt/β-catenin signaling pathway from natural products and to determine whether this activator can induce anagen hair growth in mice.
To identify materials that activate Wnt/β-catenin signaling pathway, 800 natural product extracts were screened using pTOPFlash assay and neural progenitor cell (NPC) differentiation assay. A selected extract was further tested for its effects on alkaline phosphatase (ALP) activity in human immortalized dermal papilla cell (iDPC) and the proliferation in iDPC and immortalized rat vibrissa DPC (RvDP). Finally, hair growth-promoting effects were evaluated in the dorsal skin of C57BL/6 mice.
Aconiti Ciliare Tuber (ACT) extract was one of the most active materials in both pTOPFlash and NPC differentiation assays. It promoted the differentiation of NPC cells even under proliferation-stimulating conditions (basic fibroblast growth factor: bFGF). It also increased ALP activity and proliferation of iDPC in dose-dependent manners, and it stimulated the induction of the anagen hair growth in C57BL/6 mice. These results suggest that ACT extract activates the Wnt/β-catenin signaling pathway by enhancing β-catenin transcription and has the potential to promote the induction of hair growth via activation of the stem cell activity of the dermal papilla cells.
This is the first report indicating benefits of ACT extract in hair loss prevention by triggering the activation of Wnt/β-catenin signaling pathway and induction of the anagen hair growth in mice.</description><subject>Aconiti Ciliare Tuber (ACT) extract</subject><subject>Aconitum - chemistry</subject><subject>Alkaline phosphatase (ALP)</subject><subject>Alkaline Phosphatase - metabolism</subject><subject>Animals</subject><subject>beta Catenin - metabolism</subject><subject>Cell Differentiation - drug effects</subject><subject>Cell Proliferation - drug effects</subject><subject>Dose-Response Relationship, Drug</subject><subject>Hair - drug effects</subject><subject>Hair - growth & development</subject><subject>Hair growth</subject><subject>HEK293 Cells</subject><subject>Humans</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Plant Extracts - administration & dosage</subject><subject>Plant Extracts - pharmacology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Stem Cells - metabolism</subject><subject>Transcription, Genetic - drug effects</subject><subject>Wnt Signaling Pathway - drug effects</subject><subject>Wnt/β-catenin signaling pathway</subject><issn>0024-3205</issn><issn>1879-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMFuVCEYhYnR2LH6AG4MSzf39gcucyGumolakyZualwSLhemTO5ABaa1r-WD-Ez-k6kuXUHgOyc5HyFvGfQM2Ppi1y-h9hwY70H3AOoZWTE16g7Wgj0nKwA-dIKDPCOvat0BgJSjeEnOuMC7UuOKtCsbC92W_NBuu7uS97nFtKU-BO8azYFeupxii3QTl2iLpzeHyRfqf7ZiEdj7OdrmZzo90nbrKb7Fe9tiTsfs99Qufv_qHBIpJlrjNtkF61-TF8Eu1b95Os_Jt08fbzZX3fXXz182l9edE1K0LsiBy3Wwah2EHEGB5JOTdlRKMoEzGeC_E2GenVag-aCt1hNTkx44H0cnzsn7Uy8O-3HwtZl9rM4vi00-H6phjA0jCJSFKDuhruRaiw_mrsS9LY-GgTnKNjuDss1RtgFtUB9m3j3VHyYU8S_x1y4CH06Ax5H30RdTXfTJobSCes2c43_q_wCZd4_k</recordid><startdate>20121102</startdate><enddate>20121102</enddate><creator>Park, Phil-June</creator><creator>Moon, Byoung-San</creator><creator>Lee, Soung-Hoon</creator><creator>Kim, Su-Na</creator><creator>Kim, Ah-Reum</creator><creator>Kim, Hyung-Jun</creator><creator>Park, Won-Seok</creator><creator>Choi, Kang-Yell</creator><creator>Cho, Eun-Gyung</creator><creator>Lee, Tae Ryong</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20121102</creationdate><title>Hair growth-promoting effect of Aconiti Ciliare Tuber extract mediated by the activation of Wnt/β-catenin signaling</title><author>Park, Phil-June ; Moon, Byoung-San ; Lee, Soung-Hoon ; Kim, Su-Na ; Kim, Ah-Reum ; Kim, Hyung-Jun ; Park, Won-Seok ; Choi, Kang-Yell ; Cho, Eun-Gyung ; Lee, Tae Ryong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c353t-f54256fa86f35708052bc5a78851387910425c3fddc9809249a99b18b942277c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Aconiti Ciliare Tuber (ACT) extract</topic><topic>Aconitum - chemistry</topic><topic>Alkaline phosphatase (ALP)</topic><topic>Alkaline Phosphatase - metabolism</topic><topic>Animals</topic><topic>beta Catenin - metabolism</topic><topic>Cell Differentiation - drug effects</topic><topic>Cell Proliferation - drug effects</topic><topic>Dose-Response Relationship, Drug</topic><topic>Hair - drug effects</topic><topic>Hair - growth & development</topic><topic>Hair growth</topic><topic>HEK293 Cells</topic><topic>Humans</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Plant Extracts - administration & dosage</topic><topic>Plant Extracts - pharmacology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Stem Cells - metabolism</topic><topic>Transcription, Genetic - drug effects</topic><topic>Wnt Signaling Pathway - drug effects</topic><topic>Wnt/β-catenin signaling pathway</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Park, Phil-June</creatorcontrib><creatorcontrib>Moon, Byoung-San</creatorcontrib><creatorcontrib>Lee, Soung-Hoon</creatorcontrib><creatorcontrib>Kim, Su-Na</creatorcontrib><creatorcontrib>Kim, Ah-Reum</creatorcontrib><creatorcontrib>Kim, Hyung-Jun</creatorcontrib><creatorcontrib>Park, Won-Seok</creatorcontrib><creatorcontrib>Choi, Kang-Yell</creatorcontrib><creatorcontrib>Cho, Eun-Gyung</creatorcontrib><creatorcontrib>Lee, Tae Ryong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Life sciences (1973)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Park, Phil-June</au><au>Moon, Byoung-San</au><au>Lee, Soung-Hoon</au><au>Kim, Su-Na</au><au>Kim, Ah-Reum</au><au>Kim, Hyung-Jun</au><au>Park, Won-Seok</au><au>Choi, Kang-Yell</au><au>Cho, Eun-Gyung</au><au>Lee, Tae Ryong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hair growth-promoting effect of Aconiti Ciliare Tuber extract mediated by the activation of Wnt/β-catenin signaling</atitle><jtitle>Life sciences (1973)</jtitle><addtitle>Life Sci</addtitle><date>2012-11-02</date><risdate>2012</risdate><volume>91</volume><issue>19-20</issue><spage>935</spage><epage>943</epage><pages>935-943</pages><issn>0024-3205</issn><eissn>1879-0631</eissn><abstract>The activation of Wnt/β-catenin signaling pathway plays an important role in hair follicle morphogenesis by stimulating bulge stem cells. This study was to obtain the activator of Wnt/β-catenin signaling pathway from natural products and to determine whether this activator can induce anagen hair growth in mice.
To identify materials that activate Wnt/β-catenin signaling pathway, 800 natural product extracts were screened using pTOPFlash assay and neural progenitor cell (NPC) differentiation assay. A selected extract was further tested for its effects on alkaline phosphatase (ALP) activity in human immortalized dermal papilla cell (iDPC) and the proliferation in iDPC and immortalized rat vibrissa DPC (RvDP). Finally, hair growth-promoting effects were evaluated in the dorsal skin of C57BL/6 mice.
Aconiti Ciliare Tuber (ACT) extract was one of the most active materials in both pTOPFlash and NPC differentiation assays. It promoted the differentiation of NPC cells even under proliferation-stimulating conditions (basic fibroblast growth factor: bFGF). It also increased ALP activity and proliferation of iDPC in dose-dependent manners, and it stimulated the induction of the anagen hair growth in C57BL/6 mice. These results suggest that ACT extract activates the Wnt/β-catenin signaling pathway by enhancing β-catenin transcription and has the potential to promote the induction of hair growth via activation of the stem cell activity of the dermal papilla cells.
This is the first report indicating benefits of ACT extract in hair loss prevention by triggering the activation of Wnt/β-catenin signaling pathway and induction of the anagen hair growth in mice.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>23000887</pmid><doi>10.1016/j.lfs.2012.09.008</doi><tpages>9</tpages></addata></record> |
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| subjects | Aconiti Ciliare Tuber (ACT) extract Aconitum - chemistry Alkaline phosphatase (ALP) Alkaline Phosphatase - metabolism Animals beta Catenin - metabolism Cell Differentiation - drug effects Cell Proliferation - drug effects Dose-Response Relationship, Drug Hair - drug effects Hair - growth & development Hair growth HEK293 Cells Humans Male Mice Mice, Inbred C57BL Plant Extracts - administration & dosage Plant Extracts - pharmacology Rats Rats, Sprague-Dawley Stem Cells - metabolism Transcription, Genetic - drug effects Wnt Signaling Pathway - drug effects Wnt/β-catenin signaling pathway |
| title | Hair growth-promoting effect of Aconiti Ciliare Tuber extract mediated by the activation of Wnt/β-catenin signaling |
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