Synthesis and biological evaluation of combretastatin-amidobenzothiazole conjugates as potential anticancer agents

A series of combretastatin-amidobenzothiazole conjugates have been synthesized and evaluated for their anticancer activity. All these compounds exhibited significant anticancer activity and the most potent compound (11a) showed GI50 values ranging 0.019–11 μM. Biological studies such as cell cycle d...

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Veröffentlicht in:	European journal of medicinal chemistry 2012-10, Vol.56, p.166-178
Hauptverfasser:	Kamal, Ahmed, Mallareddy, Adla, Janaki Ramaiah, M., Pushpavalli, S.N.C.V.L., Suresh, Paidakula, Kishor, Chandan, Murty, J.N.S.R.C., Rao, N. Sankara, Ghosh, Sowjanya, Addlagatta, Anthony, Pal-Bhadra, Manika
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticancer activity Antimitotic Agents - chemical synthesis Antimitotic Agents - chemistry Antimitotic Agents - pharmacology Benzothiazoles - chemistry Benzothiazoles - pharmacology Bibenzyls - chemistry Bibenzyls - pharmacology Biological and medical sciences CA-4 Cell cycle Cell Cycle - drug effects Cell Proliferation - drug effects Cell Survival - drug effects Dose-Response Relationship, Drug Drug Screening Assays, Antitumor ERK Humans MCF-7 Cells Medical sciences Miscellaneous Models, Molecular Molecular Dynamics Simulation Molecular modeling Molecular Structure Pharmacology. Drug treatments Polymerization Structure-Activity Relationship Tubulin Tubulin - metabolism Tumor Cells, Cultured
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