The Antihypertensive Actions of Statins: Modulation by Salt Intake
Hydroxy methyl glutaryl CoA inhibitors (statins) are the agents most frequently used to reduce elevated serum cholesterol. In addition to their cholesterol lowering effects, statins also have nonlipid lowering pleiotropic properties. These include reducing oxidative stress, renin-angiotensin and end...
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| Veröffentlicht in: | American journal of hypertension 2012-11, Vol.25 (11), p.1140-1148 |
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| creator | Juncos, Luis I. Juncos, Luis A. García, Nestor H. |
| description | Hydroxy methyl glutaryl CoA inhibitors (statins) are the agents most frequently used to reduce elevated serum cholesterol. In addition to their cholesterol lowering effects, statins also have nonlipid lowering pleiotropic properties. These include reducing oxidative stress, renin-angiotensin and endothelin synthesis and activity, and improving nitric oxide (NO) synthesis and availability. Thus, one would predict that statins might be able to exert an antihypertensive effect. Experimental models bear out the blood pressure lowering effects but the data from clinical trials have been inconsistent perhaps due to inappropriate experimental designs, sample size, blood pressure measurement techniques etc. Moreover, although experimental models strongly suggest a role for salt intake in the potential antihypertensive responses to statins, available clinical trials fail to report salt intake in the studied populations. The statins' antihypertensive effects remain an unsettled hypothesis and calls for a large clinical trial at a wide range of doses and a controlled salt intake. Statins meanwhile remain as a excellent option to control high cholesterol and in tissue injury prevention. |
| doi_str_mv | 10.1038/ajh.2012.105 |
| format | Article |
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In addition to their cholesterol lowering effects, statins also have nonlipid lowering pleiotropic properties. These include reducing oxidative stress, renin-angiotensin and endothelin synthesis and activity, and improving nitric oxide (NO) synthesis and availability. Thus, one would predict that statins might be able to exert an antihypertensive effect. Experimental models bear out the blood pressure lowering effects but the data from clinical trials have been inconsistent perhaps due to inappropriate experimental designs, sample size, blood pressure measurement techniques etc. Moreover, although experimental models strongly suggest a role for salt intake in the potential antihypertensive responses to statins, available clinical trials fail to report salt intake in the studied populations. The statins' antihypertensive effects remain an unsettled hypothesis and calls for a large clinical trial at a wide range of doses and a controlled salt intake. Statins meanwhile remain as a excellent option to control high cholesterol and in tissue injury prevention.</description><identifier>ISSN: 0895-7061</identifier><identifier>EISSN: 1941-7225</identifier><identifier>EISSN: 1879-1905</identifier><identifier>DOI: 10.1038/ajh.2012.105</identifier><identifier>PMID: 22833031</identifier><identifier>CODEN: AJHYE6</identifier><language>eng</language><publisher>Basingstoke: Oxford University Press</publisher><subject>Animals ; Antihypertensive agents ; Antihypertensive Agents - therapeutic use ; Arterial hypertension. Arterial hypotension ; Biological and medical sciences ; Blood and lymphatic vessels ; Blood Pressure - drug effects ; Cardiology. Vascular system ; Cardiovascular system ; Cholesterol - blood ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use ; Hyperlipidemias - drug therapy ; Hypertension - drug therapy ; Medical sciences ; Oxidative Stress - drug effects ; Pharmacology. Drug treatments ; Sodium - urine ; Sodium Chloride, Dietary - adverse effects ; Sodium Chloride, Dietary - pharmacology</subject><ispartof>American journal of hypertension, 2012-11, Vol.25 (11), p.1140-1148</ispartof><rights>American Journal of Hypertension, Ltd. © 2012 by the American Journal of Hypertension, Ltd. 2012</rights><rights>2014 INIST-CNRS</rights><rights>Copyright Nature Publishing Group Nov 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c419t-7cb8f7af16db69ecce11d1f2769d13975a0759fdf58f7925089cd992d443a7363</citedby><cites>FETCH-LOGICAL-c419t-7cb8f7af16db69ecce11d1f2769d13975a0759fdf58f7925089cd992d443a7363</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26650413$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22833031$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Juncos, Luis I.</creatorcontrib><creatorcontrib>Juncos, Luis A.</creatorcontrib><creatorcontrib>García, Nestor H.</creatorcontrib><title>The Antihypertensive Actions of Statins: Modulation by Salt Intake</title><title>American journal of hypertension</title><addtitle>Am J Hypertens</addtitle><description>Hydroxy methyl glutaryl CoA inhibitors (statins) are the agents most frequently used to reduce elevated serum cholesterol. In addition to their cholesterol lowering effects, statins also have nonlipid lowering pleiotropic properties. These include reducing oxidative stress, renin-angiotensin and endothelin synthesis and activity, and improving nitric oxide (NO) synthesis and availability. Thus, one would predict that statins might be able to exert an antihypertensive effect. Experimental models bear out the blood pressure lowering effects but the data from clinical trials have been inconsistent perhaps due to inappropriate experimental designs, sample size, blood pressure measurement techniques etc. Moreover, although experimental models strongly suggest a role for salt intake in the potential antihypertensive responses to statins, available clinical trials fail to report salt intake in the studied populations. The statins' antihypertensive effects remain an unsettled hypothesis and calls for a large clinical trial at a wide range of doses and a controlled salt intake. Statins meanwhile remain as a excellent option to control high cholesterol and in tissue injury prevention.</description><subject>Animals</subject><subject>Antihypertensive agents</subject><subject>Antihypertensive Agents - therapeutic use</subject><subject>Arterial hypertension. Arterial hypotension</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Blood Pressure - drug effects</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular system</subject><subject>Cholesterol - blood</subject><subject>Humans</subject><subject>Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use</subject><subject>Hyperlipidemias - drug therapy</subject><subject>Hypertension - drug therapy</subject><subject>Medical sciences</subject><subject>Oxidative Stress - drug effects</subject><subject>Pharmacology. Drug treatments</subject><subject>Sodium - urine</subject><subject>Sodium Chloride, Dietary - adverse effects</subject><subject>Sodium Chloride, Dietary - pharmacology</subject><issn>0895-7061</issn><issn>1941-7225</issn><issn>1879-1905</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp90M1LwzAYBvAgipsfN89SENGDnXmTJmm8zeHHYOJh81yyNGGdXTubVNh_b8qmggdP4X358eTlQegM8AAwTW_VcjEgGEiY2B7qg0wgFoSwfdTHqWSxwBx66Mi5JcY44RwOUY-QlFJMoY_uZwsTDStfLDZr03hTueIzLLQv6spFtY2mXvmicnfRS523per20XwTTVXpo3Hl1bs5QQdWlc6c7t5j9Pb4MBs9x5PXp_FoOIl1AtLHQs9TK5QFns-5NFobgBwsEVzmQKVgCgsmbW5ZYJKwcLzOpSR5klAlKKfH6Hqbu27qj9Y4n60Kp01ZqsrUrcsAQkxKSZIGevGHLuu2qcJ1nSKCsoTJoG62Sje1c42x2bopVqrZZICzrtssdJt13YaJBX6-C23nK5P_4O8yA7jcAeW0Km2jKl24X8c5wwnQ4K62rm7X_3_5BSuxi6o</recordid><startdate>20121101</startdate><enddate>20121101</enddate><creator>Juncos, Luis I.</creator><creator>Juncos, Luis A.</creator><creator>García, Nestor H.</creator><general>Oxford University Press</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20121101</creationdate><title>The Antihypertensive Actions of Statins: Modulation by Salt Intake</title><author>Juncos, Luis I. ; Juncos, Luis A. ; García, Nestor H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c419t-7cb8f7af16db69ecce11d1f2769d13975a0759fdf58f7925089cd992d443a7363</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Animals</topic><topic>Antihypertensive agents</topic><topic>Antihypertensive Agents - therapeutic use</topic><topic>Arterial hypertension. Arterial hypotension</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Blood Pressure - drug effects</topic><topic>Cardiology. Vascular system</topic><topic>Cardiovascular system</topic><topic>Cholesterol - blood</topic><topic>Humans</topic><topic>Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use</topic><topic>Hyperlipidemias - drug therapy</topic><topic>Hypertension - drug therapy</topic><topic>Medical sciences</topic><topic>Oxidative Stress - drug effects</topic><topic>Pharmacology. 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In addition to their cholesterol lowering effects, statins also have nonlipid lowering pleiotropic properties. These include reducing oxidative stress, renin-angiotensin and endothelin synthesis and activity, and improving nitric oxide (NO) synthesis and availability. Thus, one would predict that statins might be able to exert an antihypertensive effect. Experimental models bear out the blood pressure lowering effects but the data from clinical trials have been inconsistent perhaps due to inappropriate experimental designs, sample size, blood pressure measurement techniques etc. Moreover, although experimental models strongly suggest a role for salt intake in the potential antihypertensive responses to statins, available clinical trials fail to report salt intake in the studied populations. The statins' antihypertensive effects remain an unsettled hypothesis and calls for a large clinical trial at a wide range of doses and a controlled salt intake. Statins meanwhile remain as a excellent option to control high cholesterol and in tissue injury prevention.</abstract><cop>Basingstoke</cop><pub>Oxford University Press</pub><pmid>22833031</pmid><doi>10.1038/ajh.2012.105</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Antihypertensive agents Antihypertensive Agents - therapeutic use Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Blood Pressure - drug effects Cardiology. Vascular system Cardiovascular system Cholesterol - blood Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use Hyperlipidemias - drug therapy Hypertension - drug therapy Medical sciences Oxidative Stress - drug effects Pharmacology. Drug treatments Sodium - urine Sodium Chloride, Dietary - adverse effects Sodium Chloride, Dietary - pharmacology |
| title | The Antihypertensive Actions of Statins: Modulation by Salt Intake |
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